Breast milk and its impact on maturation of the neonatal immune system

Turfkruyer, Mathilde; Verhasselt, Valérie

doi:10.1097/qco.0000000000000165

Cited by 113 publications

(105 citation statements)

References 73 publications

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“…In human neonates, FcRn is expressed on the luminal surface of enterocyte for a very short period, only a few hours or days after birth. In contrast, FcRn persists for the whole life on the contra‐luminal surface of those cells and contributes to the transport of Ig, including secretory IgA (SIgA), from the submucosae and blood to the mucosal surfaces . This receptor is also present on the surface of syncytiotrophoblastic cells where it ensures active transport of maternal IgG across the placenta to fetal blood …”

Section: (Re)defining Neonatal Gut Closurementioning

confidence: 99%

“…With this respect, microbial colonization of the gut occurring early in life plays a crucial role in the immune response development . Breastfeeding and breastmilk consumption, through a variety of synergistic mechanisms, contribute to the appropriate selection of commensal bacterial populations in the infant gastrointestinal system and to the final maturation of the neonatal immune system …”

Section: The Neonatal Intestinal Mucosal Immune System: In Need Of MImentioning

confidence: 99%

“…Breastfeeding promotes a favorable intestinal commensalism in the infant . In addition to direct exposure of the newborn gastrointestinal tract to maternal gut and vaginal microbiome flora during delivery, the breastmilk microbiome plays an indirect role in transfer of maternal gut bacteria through an existing maternal entero‐mammary axis .…”

Section: The Neonatal Intestinal Mucosal Immune System: In Need Of MImentioning

confidence: 99%

See 2 more Smart Citations

Breastmilk cell trafficking induces microchimerism‐mediated immune system maturation in the infant

Molès

Tuaillon²,

Kankasa

et al. 2018

Pediatric Allergy Immunology

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Initiating breastfeeding within the first hour of life confers an important benefit in terms of child mortality and severe morbidity. Intestinal permeability to ingested macromolecules and immunoglobulins is limited to the first days of human life. These exchanges cease in the very early post-partum period but may increase beyond the neonatal period in response to local inflammation or introduction of a weaning food. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Section: (Re)defining Neonatal Gut Closurementioning

confidence: 99%

Section: The Neonatal Intestinal Mucosal Immune System: In Need Of MImentioning

confidence: 99%

Section: The Neonatal Intestinal Mucosal Immune System: In Need Of MImentioning

confidence: 99%

See 1 more Smart Citation

Breastmilk cell trafficking induces microchimerism‐mediated immune system maturation in the infant

Molès

Tuaillon²,

Kankasa

et al. 2018

Pediatric Allergy Immunology

View full text Add to dashboard Cite

show abstract

“…The transfer of maternal immune factors, through the placenta and breast milk, to the fetus and young infant plays a critical role in augmenting defense against infectious pathogens and participates in the establishment of immune homeostasis in early life. Specifically, maternal antibodies are actively transferred to the fetus in utero and provide protection against pathogens that are prevalent in the community (5), and breast-feeding extends the time for transfer of maternal immune factors, providing important protection against infectious disease morbidity and mortality in infancy (6, 7). …”

Section: Introductionmentioning

confidence: 99%

Transfer of Maternal Antimicrobial Immunity to HIV-Exposed Uninfected Newborns

et al. 2016

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The transfer of maternal immune factors to the newborn is critical for protection from infectious disease in early life. Maternally acquired passive immunity provides protection until the infant is beyond early life’s increased susceptibility to severe infections or until active immunity is achieved following infant’s primary immunization. However, as reviewed here, human immunodeficiency virus (HIV) infection alters the transfer of immune factors from HIV-infected mothers to the HIV-exposed newborns and young infants. This may relate to the immune activation in HIV-infected pregnant women, associated with the production of inflammatory cytokines at the maternofetal interface associated with inflammatory responses in the newborn. We also summarize mother-targeting interventions to improve the health of infants born to HIV-infected women, such as immunization during pregnancy and reduction of maternal inflammation. Maternal immunization offers the potential to compensate for the decreased transplacentally transferred maternal antibodies observed in HIV-exposed infants. Current data suggest reduced immunogenicity of vaccines in HIV-infected pregnant women, possibly reducing the protective impact of maternal immunization for HIV-exposed infants. Fortunately, levels of antibodies appear preserved in the breast milk of HIV-infected women, which supports the recommendation to breast-feed during antiretroviral treatment to protect HIV-exposed infants.

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“…Multiple aetiological pathways need to be considered because socially‐induced postpartum disorders are likely to affect several components of the mother‐infant interaction. Recent studied suggest that depression is associated with the dysregulation of maternal immune functioning to which offspring can be directly exposed via lactation . Variation in milk pro‐inflammatory cytokine levels affect offspring neurocognitive development, particularly hippocampal development and memory .…”

Section: Introductionmentioning

confidence: 99%

Maternal social environment affects offspring cognition through behavioural and immune pathways in rats

Pittet

Caenegem

Hicks-Nelson

et al. 2019

J Neuroendocrinology

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The social environment of lactation is a key etiological factor for the occurrence of postpartum disorders affecting women and their children. Postpartum depression and anxiety disorders are highly prevalent in new mothers and negatively affect offspring’s cognitive development through mechanisms which are still unclear. Here, using a rat model, we manipulated the maternal social environment during lactation and explored the pathways through which social isolation (vs. the opportunity for limited social interaction with another lactating female, from 1 day before parturition to postpartum day 16) and chronic social conflict (daily exposure to a male intruder from postpartum day 2 to day 16) affect offspring learning and memory, measured at 40 to 60 days of age. We specifically explored the consequences of these social treatments on two main hypothesized mediators likely to affect offspring neurophysiological development: the quality of maternal care and maternal inflammation factors (brain‐derived neurotrophic factor, granulocyte‐macrophage colony‐stimulating factor, intercellular adhesion molecule 1, tissue inhibitor of metalloproteinases 1 and vascular endothelial growth factor) likely to influence offspring development through lactation. Maternal rats which had the opportunity to interact with another lactating female spent more time with their pups which, in turn, displayed improved working and reference memory. Social stress affected maternal plasma levels of cytokines that were associated with cognitive deficits in their offspring. However, females subjected to social stress were protected from these stress‐induced immune changes and associated offspring cognitive impairment by increased social affiliation. These results underscore the effects of social interaction for new mothers and their offspring and can be used to inform the development of clinical preventative measures and interventions.

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Breast milk and its impact on maturation of the neonatal immune system

Abstract: We propose that the neonate immune system and maternal milk represent an entity necessary to ensure not only appropriate function in early life but also long term immune homeostasis.

Cited by 113 publications

References 73 publications

Breastmilk cell trafficking induces microchimerism‐mediated immune system maturation in the infant

Breastmilk cell trafficking induces microchimerism‐mediated immune system maturation in the infant

Transfer of Maternal Antimicrobial Immunity to HIV-Exposed Uninfected Newborns

Maternal social environment affects offspring cognition through behavioural and immune pathways in rats

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