Breast Metastasis in Esophagus Cancer: Literature Review and Report on a Case

Ghibour, Abdulaziz; Shaheen, Osama

doi:10.1155/2016/8121493

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…One theory proposing to explain the metastasis of esophageal cancer to the breast suggests that it begins with the spread from the primary esophageal lesion through the draining lymphatic vessels to the thoracic duct [ 3 ]. Subsequently, there could be retrograde transmission to the breast via the internal mammary lymph nodes [ 3 , 20 ]. Tumor cells may access the internal mammary lymph nodes by infiltrating the intercostal vessels, which form collateral branches with the thoracic duct [ 3 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, there could be retrograde transmission to the breast via the internal mammary lymph nodes [ 3 , 20 ]. Tumor cells may access the internal mammary lymph nodes by infiltrating the intercostal vessels, which form collateral branches with the thoracic duct [ 3 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Esophageal cancer stands as the sixth-leading cause of cancer-related fatalities worldwide [ 3 ]. Metastasis in esophageal cancer frequently involves non-regional lymph nodes, peritoneum, lungs, liver, bone, and brain [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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A Case of Esophageal Adenocarcinoma Metastatic to the Breast

Kotla,

Qiu,

2024

Cureus

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Metastatic carcinoma infiltrating the breast from extramammary malignancies is an infrequent occurrence. Extramammary carcinomas that may be metastatic to the breast include gastrointestinal cancers, ovarian cancer, and lung cancer, among others. These metastatic lesions often pose a diagnostic challenge, resembling primary breast cancer in both clinical and radiographic presentations. The incidence of esophageal cancer metastasizing to the breast is low. Esophageal cancer more commonly spreads to locoregional lymph nodes, lungs, liver, and bone. We present a unique case where primary esophageal adenocarcinoma metastasized to the breast. Our aim is to raise diagnostic awareness by delineating the clinical and pathological findings of this exceptionally infrequent disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Case of Esophageal Adenocarcinoma Metastatic to the Breast

Kotla,

Qiu,

2024

Cureus

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Esophageal Cancer Metastases to Unexpected Sites: A Systematic Review

Shaheen

Ghibour

Alsaid

2017

Gastroenterology Research and Practice

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The most common pattern of esophageal cancer metastases (ECM) is to the lymph nodes, lung, liver, bones, adrenal glands, and brain. On the other hand, unexpected metastasis (UM) spread to uncommon sites has increasingly reported and consequently affected the pathway of diagnosis, staging, and management. Using the PubMed database, a systematic search of the following headings “Esophageal” and “Metastasis” or “Metastases” was performed, 10049 articles were identified, and the articles were included if they demonstrated unexpected ECM. 84% of cases were men with an average age of 60.7 years. EC was located in the lower third in 65%. Two-thirds of the UM originated from the lower esophagus, and the two major histological types were adenocarcinoma 40% and squamous cell carcinoma 60%. Metastases were disseminated toward five main anatomical sites: the head and neck (42%), thoracic (17%), abdomen and pelvis (25%), extremities (9%), and multiple skin and muscle metastases (7%). The EC metastases were found to be synchronous 42% and metachronous 58%, isolated in 53.5% and multiple in 46.5%. The overall survival rate was 10.2 months. Since distant metastases are responsible for most EC-related deaths, understanding of ECM dissemination patterns needs more extensive studies. These critical data are the cornerstone of optimal cancer approach and treatment.

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Neoplasia de Esôfago com Metástase Mamária: Relato de Caso

Santos,

Felitti,

Wludarski

et al. 2024

Rev. Bras. Cancerol.

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Introdução: A neoplasia de esôfago é o sétimo câncer mais frequentemente diagnosticado e a sexta principal causa de morte relacionada ao câncer no mundo. No Brasil, ocupa a 13ª posição entre os tipos de câncer mais frequentes. Os sítios mais comuns de disseminação do câncer esofágico são pulmão, fígado e ossos. As metástases do câncer de esôfago para a mama são extremamente raras e pouco documentadas na literatura. Relato de caso: Homem, 45 anos, diagnosticado com adenocarcinoma de esôfago após manifestar dispepsia e epigastralgia. A investigação por endoscopia digestiva alta revelou adenocarcinoma de esôfago, sem metástases a distância. Foi submetido à esofagectomia e quimioterapia adjuvante. Na tomografia por emissão de pósitrons (PET-CT), realizada pós-tratamento, foi detectada recidiva local, iniciando terapia paliativa. Pouco antes, uma nodulação na mama direita foi diagnosticada inicialmente como lesão primária da mama, carcinoma do tipo não especial, triplo-negativo. Contudo, uma revisão da lâmina revelou um adenocarcinoma pouco diferenciado metastático do esôfago, resultando em dois diagnósticos discordantes. Uma terceira análise do material da mama por imuno-histoquímica confirmou a lesão metastática secundária ao esôfago. Durante o tratamento, o paciente apresentou crise convulsiva, com diagnóstico de implante cerebral secundário. Realizou radioterapia em lesão do sistema nervoso central e mastectomia. O PET-CT revelou ausência de sinais de atividade metabólica anormal. Atualmente, encontra-se assintomático com programação terapêutica de imunoterapia de manutenção associada a bloqueio do HER2. Conclusão: Este caso sublinha a raridade da metástase mamária no câncer de esôfago e a importância crucial da imuno-histoquímica para um diagnóstico diferencial preciso e planejamento terapêutico adequado.

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Breast Metastasis in Esophagus Cancer: Literature Review and Report on a Case

Cited by 3 publications

References 8 publications

A Case of Esophageal Adenocarcinoma Metastatic to the Breast

A Case of Esophageal Adenocarcinoma Metastatic to the Breast

Esophageal Cancer Metastases to Unexpected Sites: A Systematic Review

Neoplasia de Esôfago com Metástase Mamária: Relato de Caso

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