Breast metastasis 18 years after nephrectomy for renal cell carcinoma: a case report

Elouarith, Ihssan; Bouhtouri, Yassine; Elmajoudi, Salma; Bekarsabein, Salma; Ech-charif, Soumaya; Khmou, Mouna; Messaoudi, Hamza; Mahdi, Youssef; Hachi, Hafid; Khannoussi, Basma El

doi:10.1093/jscr/rjac116

Journal of Surgical Case Reports

2022

DOI: 10.1093/jscr/rjac116

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Breast metastasis 18 years after nephrectomy for renal cell carcinoma: a case report

Ihssan Elouarith

Yassine Bouhtouri

Salma Elmajoudi

et al.

Abstract: Metastasis of renal clear cell carcinoma (RCC) to the breast is exceptional. Breast metastases of extra-mammary tumors are rare and usually involve melanoma, lymphoma or leukemia. We report the case of a patient with breast metastasis of renal clear cell carcinoma occurring 18 years after nephrectomy. A history of RCC should always raise suspicion about breast metastasis, a situation that remains exceptional and whose diagnosis relies on anatomopathology.

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Cited by 2 publications

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Bilateral breast metastasis from renal cell carcinoma, do not overlook this diagnosis: case report

AlKhateeb,

Abdel-Hadi,

Darwish

et al. 2024

Egypt J Radiol Nucl Med

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Background Renal cell carcinoma rarely metastasizes to the breast. Few cases are reported in the literature. We describe a unique case of bilateral breast metastasis from an RCC treated five years ago. To the best of our knowledge, this would be the first reported case in Egypt. Case presentation A 65-year-old Egyptian woman who underwent a nephrectomy for a renal cell carcinoma 5-years ago, showed up complaining of bloody nipple discharge from her right breast without any palpable lumps. Mammo-sonography showed multiple bilateral regular breast masses and a worrisome left axillary lymph node. Needle core biopsies were obtained and a final histopathological diagnosis of bilateral metastatic deposits from clear cell renal cell carcinoma (RCC) was made. Conclusion The differential diagnosis of bilateral breast masses should consider metastatic disease of the breast, particularly in patients with a previous history of malignancies.

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Bilateral breast metastasis from renal cell carcinoma, do not overlook this diagnosis: case report

AlKhateeb,

Abdel-Hadi,

Darwish

et al. 2024

Egypt J Radiol Nucl Med

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Secondary Breast Malignancy from Renal Cell Carcinoma: Challenges in Diagnosis and Treatment—Case Report

et al. 2023

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Renal cell carcinoma represents about 2% of all malignant tumours in adults. Metastases of the primary tumour in the breast make up to about 0.5–2% of the cases. Renal cell carcinoma metastases in the breast are extremely rare and have been sporadically recorded in the literature. In this paper, we present the case of a patient with breast metastasis of renal cell carcinoma 11 years after primary treatment. Case presentation: An 82-year-old female who had right nephrectomy due to renal cancer in 2010 felt a lump in her right breast in August 2021, whereby a clinical examination revealed a tumour at the junction of the upper quadrants of her right breast, about 2 cm, movable toward the base, vaguely limited, and with a rough surface. The axillae were without palpable lymph nodes. Mammography showed a circular and relatively clearly contoured lesion in the right breast. Ultrasound showed an oval lobulated lesion of 19 × 18 mm at the upper quadrants, with strong vascularisation and without posterior acoustic phenomena. A core needle biopsy was performed, and the histopathological findings and obtained immunophenotype indicated a metastatic clear cell carcinoma of renal origin. A metastasectomy was performed. Histopathologically, the tumour was without desmoplastic stroma, comprising predominantly solid-type alveolar arrangements of large moderately polymorphic cells, bright and abundant cytoplasm, and round vesicular cores with focally prominent nuclei. Immunohistochemically, tumour cells were diffusely positive for CD10, EMA, and vimentin, and negative for CK7, TTF-1, renal cell antigen, and E-cadherin. With a normal postoperative course, the patient was discharged on the third postoperative day. After 17 months, there were no new signs of the underlying disease spreading at regular follow-ups. Conclusion: Metastatic involvement of the breast is relatively rare and should be suspected in patients with a prior history of other cancers. Core needle biopsy and pathohistological analysis are required for the diagnosis of breast tumours.

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Breast metastasis 18 years after nephrectomy for renal cell carcinoma: a case report

Cited by 2 publications

References 10 publications

Bilateral breast metastasis from renal cell carcinoma, do not overlook this diagnosis: case report

Bilateral breast metastasis from renal cell carcinoma, do not overlook this diagnosis: case report

Secondary Breast Malignancy from Renal Cell Carcinoma: Challenges in Diagnosis and Treatment—Case Report

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