Breast Mass Evaluation: Factors Influencing the Quality of US Elastography

Chang, Jung Min; Moon, Woo Kyung; Cho, Nariya; Kim, Seung Ja

doi:10.1148/radiol.10101414

Cited by 163 publications

(108 citation statements)

References 19 publications

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“…A mechanical property or parameter is then computed and mapped into an image (elastogram), enabling visualization of tissue stiffness. Variants of elastography based on ultrasound (16) and MRI (17) have been developed as diagnostic tools to evaluate suspicious breast lesions, and a number of large clinical studies have been performed (18)(19)(20). However, the relatively low spatial resolution of existing elastography techniques may limit their suitability for intraoperative tumor margin assessment.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue

et al. 2015

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An accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high reexcision rates without resorting to the removal of excess healthy tissue. Optical coherence microelastography (OCME) is a three-dimensional, high-resolution imaging technique that is sensitive to microscale variations of the mechanical properties of tissue. As the tumor modifies the mechanical properties of breast tissue, OCME has the potential to identify, on the microscale, involved regions of fresh, unstained tissue. OCME is based on the use of optical coherence tomography (OCT) to measure tissue deformation in response to applied mechanical compression. In this feasibility study on 58 ex vivo samples from patients undergoing mastectomy or wide local excision, we demonstrate the performance of OCME as a means to visualize tissue microarchitecture in benign and malignant human breast tissues. Through a comparison with corresponding histology and OCT images, OCME is shown to enable ready visualization of features such as ducts, lobules, microcysts, blood vessels, and arterioles and to identify invasive tumor through distinctive patterns in OCME images, often with enhanced contrast compared with OCT. These results lay the foundation for future intraoperative studies. Cancer Res; 75(16); 3236–45. ©2015 AACR.

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Section: Introductionmentioning

confidence: 99%

Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue

et al. 2015

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“…The two most frequently used elastography techniques in the breast are strain elastography and shear-wave elastography [58]. Shear-wave technology is reported to be highly reproducible [59] unlike strain elastography which can have a significant amount of interobserver variability [60]. Both techniques are used in conjunction with B-mode ultrasound, but differ in how they measure tissue stiffness.…”

Section: Elastographymentioning

confidence: 99%

Breast Ultrasound Past, Present, and Future

Rapelyea¹,

Marks²

2018

Breast Imaging

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This chapter will review the utilization of breast ultrasound for screening and diagnostic purposes. Currently, ultrasound is primarily used to investigate palpable lesions in women less than 30 years old, to provide further characterization of abnormal mammographic findings, and to guide invasive breast interventions. Innovations in ultrasound technology have improved the detection and diagnosis of breast cancer. Computer-aided detection (CAD), elastography, quantitative breast ultrasound technology, and ultrasound contrast agents (microbubbles) were developed to improve diagnostic accuracy. These advancements have the potential to impact overall survival by detecting cancers that are smaller and less aggressive.

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“…Data acquisition and interpretation of elasticity images are largely dependent on the examiner´s experience, and significant interobserver variability has been found [3,4,13,14]. The real-time elastogram is displayed with a scale based on the relative strain of the tissues.…”

Section: We Can Distinguish Two Types Of Elastographymentioning

confidence: 99%

“…With SWE, a quantitative measure of the lesion stiffness is obtained either in an FOV or pixel by pixel using a color map. According to a recent study, a value of 50kPa or greater is indicative of a malignant lesion, whereas a value less of 50kPa is indicative of a benign lesion [5,14,[19][20][21] (Figure 2). Typical values of tissue elasticity in the breast.…”

Section: We Can Distinguish Two Types Of Elastographymentioning

confidence: 99%

“…This technique allows a qualitative assessment of the lesion. With real-time ultrasound elastography, the physical properties of soft tissue are revealed through characterization of the differences in stiffness between the region of interest and the surrounding tissue based on mechanically induced deformation (strain) of structures during B-mode scanning [8].Data acquisition and interpretation of elasticity images are largely dependent on the examiner´s experience, and significant interobserver variability has been found [3,4,13,14]. The real-time elastogram is displayed with a scale based on the relative strain of the tissues.…”

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Breast Elastography: Present and Future

Fernadez¹

2017

IJRRT

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Objective: Make a literature review of breast elastography, an imaging technique not so new today, for many still unknown in diagnostic ultrasound, which emerges in order to characterize complementarily tissues of the breast, contributing to differential diagnosis between benign and malignant lesions.Review: Today breast cancer is by far the most common cancer in women. Mammography and ultrasound has become an indispensable diagnostic tandem within the breast image, increasing the sensitivity of ultrasound mammography by 15% and both techniques are able to characterize most breast lesions. Using these techniques together we achieve a sensitivity of 85-100% and a specificity of 76-80%, specially in dense breasts where mammography is significantly limited [1]. Copyright: ©2017 Fernadez Keywords: We can distinguish two types of elastographyCompression elastography and "shear-wave" elastography (SWE).Compression elastography (strain) produces an image based on the displacement of the tissue from an external or patient source, and the movement of the tissue shows the direction of US beam propagation. This technique allows a qualitative assessment of the lesion. With real-time ultrasound elastography, the physical properties of soft tissue are revealed through characterization of the differences in stiffness between the region of interest and the surrounding tissue based on mechanically induced deformation (strain) of structures during B-mode scanning [8].Data acquisition and interpretation of elasticity images are largely dependent on the examiner´s experience, and significant interobserver variability has been found [3,4,13,14]. The real-time elastogram is displayed with a scale based on the relative strain of the tissues. The technique to obtain the optimal images varies with the algorithm used by the manufacturer of the ultrasound system. Monitoring of the B-mode image to confirm the lesion is only displaced in depth during scanning and otherwise moving in the field of view (FOV) will allow optimal images. With the displacement technique, one cannot be surveying the breast; scanning must be done in one stationary position.Modern US devices allow combined elasticity and 2D real time assessment of tissues or lesions, using the same probe as conventional ultrasound imaging [15]. Sonoelastography demonstrates the elasticity of a lesion related to the elasticity of the surrounding tissue [13], so the final result is based on the comparison between pre and postcompression data [10,15,16], however it´s difficult with this technique to amount of the stress during the compression process.In contrast to strain elastography, SWE uses an acoustic radiation force impulse created by a focused ultrasound beam, which allows measurement of the propagation speed of shear waves within the tissue to locally quantify its stiffness in kilopascals or m/s. Because the speed of sound through tissues is dependent on the "stiffness" of these tissues, a quantitative value of the stiffness can be obtained, shear wave velocity is propo...

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Breast Mass Evaluation: Factors Influencing the Quality of US Elastography

Abstract: Breast thickness at the location of the lesion was the most important factor influencing image quality at US elastography. Sensitivity for classification of benign and malignant masses improved with higher quality scores.

Cited by 163 publications

References 19 publications

Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue

Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue

Breast Ultrasound Past, Present, and Future

Breast Elastography: Present and Future

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