Breast Lesions in Young Girls

Farrow, Joseph H.; Ashikari, H

doi:10.1016/s0039-6109(16)38784-9

Cited by 60 publications

(38 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metastatic sarcoma in breast has also been reported in adults, but RMS very rarely in recent decades, and then only in the youngest patients in adult series [20], possibly reflecting an increase in the recognition of other tumor types. Patients with RMS reported prior to 1980, including adolescents [18,33], have not been included in Figure 1 or Tables III and IV [44]. All tumors were of the alveolar subtype.…”

Section: Discussionmentioning

confidence: 99%

Primary and metastatic rhabdomyosarcoma in the breast: Neoplasms of adolescent females, a report from the Intergroup Rhabdomyosarcoma Study

Hays

Donaldson

Shimada

et al. 1997

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

The occurrence of rhabdomyosarcoma (RMS) primary in or metastatic to breast has been regarded as an uncommon event, associated with an unfavorable outcome. Records of 26 patients with diagnoses of breast RMS, either primary or secondary, entered in the Intergroup Rhabdomyosarcoma Study (IRS) (1972–1992) were reviewed and compared with data regarding 47 similar patients in published reports. Of the 26 IRS cases, the histologic subtype was alveolar in 24, embryonal in 1, and not determined in 1. All were female with ages ranging from 11.5 to 20.2 years (median, 15.2 years; mode, 14–16 years). This compact age distribution of both primary (n = 7) and metastatic (n = 19) breast RMS was seen in previously reported series. Among the 19 cases of RMS with initial dissemination to breast, primary tumor sites were: extremity (n = 8), nasopharynx/paranasal sinuses (n = 7), and trunk (n = 4). IRS treatment was risk‐based according to site and extent of disease. Four of 7 patients with primary RMS remain disease free 2.9 to 7 years post diagnosis. Among 19 patients with RMS initially metastatic to breast, including 7 in IRS clinical group IV at original diagnosis, three are disease free at 7.6, 15.7 and 17.0 years. Conclusions: primary or metastatic RMS in breast is almost confined to adolescent females having tumors with alveolar histology. Approximately one‐half of the patients with primary breast disease and 15% of those with metastatic breast disease as an initial recurrence are long‐term survivors. Med. Pediatr. Oncol. 29:181–189, 1997. © 1997 Wiley‐Liss, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary and metastatic rhabdomyosarcoma in the breast: Neoplasms of adolescent females, a report from the Intergroup Rhabdomyosarcoma Study

Hays

Donaldson

Shimada

et al. 1997

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

show abstract

“…Indeed only 1 small FA (1.5 cm) was necrotic. The largest FA reported [3] weighed 800 g and had no evidence of infarction. Necrosis is not seen in adult FA, except during pregnancy or lactation [ 141.…”

Section: Behavior and Microscopical Featuresmentioning

confidence: 95%

“…The FA with collagenous stroma presented at follow-up examination with a large keloid. DISCUSSION The problem of diagnosis and therapy of breast masses in adolescents is limited to females [1, 3,6,10]. FA are most common, the earliest reported occurring at the age of 10 years, and, except for mastitis and cysts, diseases of adults are rare.…”

Section: Behavior and Microscopical Featuresmentioning

confidence: 99%

Breast masses in adolescent females

Siegal¹,

Kaufman²,

Siegal³

1992

Journal of Surgical Oncology

View full text Add to dashboard Cite

In a retrospective study of 38 adolescent females operated on for mammary masses, 42 fibroadenomata (FA), 2 fibrous scars around abscesses, and one papilloma were found. All were postmenarchal. Clinical and pathological features were reviewed and the patients reexamined or interviewed. FA were mostly asymptomatic and removed a few weeks after incidental discovery. They were often seen in Jewish girls of parents born in North Africa and the Middle East, and were more frequently located in the outer superior quadrant of the left breast. New FA appeared in almost half of the cases later on in the same breast, as well as in the other breast, or bilaterally. Necrosis occurred in three FA and was unrelated to the size of the tumor. There was no correlation between the size of FA, multiplicity, or necrosis, nor between increased stromal or epithelial atypia, cellularity, or mitotic activity. One explanation for the high rate of multiplicity might be related to this neoplasm occurring in an actively developing organ under hormonal control. There was no increased breast carcinoma apparent in the family history. Therefore, except in cases of fast-growing tumors, a conservative approach is recommended because of the frequency of multiple FA as well as aesthetical postoperative complications.

show abstract

“…The vast majority of Fi broadenomas in young women are clinically and histolog ically similar to the 'adult' type found in older women. Less than 5% grow rapidly and display the histological characteristics of 'giant' fibroadenomas [1]. Giant fi broadenomas are solitary lesions with a diameter >5 cm and/or a weight >500 g. Giant fibroadenomas are the most common cause of massive enlargement of the breast in young females.…”

Section: Introductionmentioning

confidence: 99%

Multiple Giant Fibroadenomas: Clinical Presentation and Radiologic Findings

Schneider¹,

Laubenberger²,

Kommoss

et al. 1997

Gynecol Obstet Invest

View full text Add to dashboard Cite

We describe the case of a 25-year-old Caucasian woman suffering from unilateral enlargement of the breast. Morphologic evaluation of various imaging modalities including mammography, ultrasound, and magnetic resonance imaging suggested a benign tumor embedded in stromal tissue. The time course of the Gd-DTPA uptake in dynamic magnetic resonance imaging, however, was also compatible with a malignant lesion. Postoperative pathological examination revealed multiple giant fibroadenomas, a rare disease, usually encountered in black female adolescents. Radiologic presentation, differential diagnosis, and morphologic findings are discussed, and a review of the literature is contained herein.

show abstract

Breast Lesions in Young Girls

Cited by 60 publications

References 1 publication

Primary and metastatic rhabdomyosarcoma in the breast: Neoplasms of adolescent females, a report from the Intergroup Rhabdomyosarcoma Study

Primary and metastatic rhabdomyosarcoma in the breast: Neoplasms of adolescent females, a report from the Intergroup Rhabdomyosarcoma Study

Breast masses in adolescent females

Multiple Giant Fibroadenomas: Clinical Presentation and Radiologic Findings

Contact Info

Product

Resources

About