Breast Intracystic Papillary Carcinoma: An Update

Caldéraro, Julien; Espié, Marc; Duclos, J.; Giachetti, S.; Wehrer, Delphine; Sandid, Wissam; Cahen-Doidy, Laurence; Albiter, M.; Janin, Anne; Roquancourt, Anne de

doi:10.1111/j.1524-4741.2009.00823.x

Cited by 41 publications

(30 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both, papillary cancers and those with medullary features were subtypes considered as prognostic favorable. [54][55][56][57] Although we cannot explain this finding, it could be possible that papillary and medullary cancers share a particular molecular environment that is nonresponsive to 8p deletion. Our observation that 8p deletions were particularly rare in tubular carcinomas fits well to the low grade and good prognosis of these cancers, however.…”

Section: Discussionmentioning

confidence: 95%

8p deletion is strongly linked to poor prognosis in breast cancer

Lebok

Mittenzwei

Kluth

et al. 2015

Cancer Biology & Therapy

View full text Add to dashboard Cite

Deletions of chromosome 8p occur frequently in breast cancers, but analyses of its clinical relevance have been limited to small patient cohorts and provided controversial results. A tissue microarray with 2,197 breast cancers was thus analyzed by fluorescence in-situ hybridization using an 8p21 probe in combination with a centromere 8 reference probe. 8p deletions were found in 50% of carcinomas with no special type, 67% of papillary, 28% of tubular, 37% of lobular cancers and 56% of cancers with medullary features. Deletions were always heterozygous. 8p deletion was significantly linked to advanced tumor stage (P < 0.0001), high-grade (P < 0.0001), high tumor cell proliferation (Ki67 Labeling Index; P < 0.0001), and shortened overall survival (P < 0.0001). For example, 8p deletion was seen in 32% of 290 grade 1, 43% of 438 grade 2, and 65% of 427 grade 3 cancers. In addition, 8p deletions were strongly linked to amplification of MYC (P < 0.0001), HER2 (P < 0.0001), and CCND1 (p D 0.001), but inversely associated with ER receptor expression (p D 0.0001). Remarkably, 46.5% of 8p-deleted cancers harbored amplification of at least one of the analyzed genes as compared to 27.5% amplifications in 8p-non-deleted cancers (P < 0.0001). In conclusion, 8p deletion characterizes a subset of particularly aggressive breast cancers. As 8p deletions are easy to analyze, this feature appears to be highly suited for future DNA based prognostic breast cancer panels. The strong link of 8p deletion with various gene amplifications raises the possibility of a role for regulating genomic stability.

show abstract

Section: Discussionmentioning

confidence: 95%

8p deletion is strongly linked to poor prognosis in breast cancer

Lebok

Mittenzwei

Kluth

et al. 2015

Cancer Biology & Therapy

View full text Add to dashboard Cite

show abstract

“…However, recent studies where myoepithelial cells were not detected around papillary carcinoma with DCIS created doubts on the presence of another type of IPC between in situ and invasive forms (8,9). The rate of invasive focus is reported as 40% in many series, although it may vary (2,8,10). The rate of lymph node metastases range between 0-36%, and is much lower than that in normal breast cancer (3).…”

Section: Discussionmentioning

confidence: 97%

Intracystic Carcinoma of the Breast: Report of Two Cases

et al. 2015

View full text Add to dashboard Cite

Intracystic papillary carcinoma of the breast (IPC) is usually seen in postmenopausal elderly women. Its prognosis is much better than other type of breast tumors, and usually do not contain invasive components. Surgical excision with negative margins and axillary sentinel lymph node sampling is the recommended treatment. Two cases of intracystic papillary carcinoma of the breast that was treated at our clinic are herein presented. Both cases were postmenopausal, were both positive for estrogen and progesterone receptors and negative for HER 2. They underwent breast-conserving surgery. One patient had an invasive focus, therefore axillary lymph node sampling was performed, and the sentinel lymph node was not metastatic. This patient received hormonal therapy as well as radiotherapy. In the other case, there was no invasive focus and the surgical margins were negative, therefore, additional surgery was not performed. The patient is receiving hormonal therapy. Intracystic carcinoma of the breast should be kept in mind especially in elderly patients with breast cysts, with clinically or radiologically suspicious features, and biopsy and local excision should be considered. Although there is not any standard approach for patients with IPC, each patient must be evaluated for surgery and should be individually assessed in terms of adjuvant therapy

show abstract

“…Intra cystic papillary carcinoma is a solitary, centrally located malignant papillary proliferation within an encysted or cystically dilated duct. IPC was considered to be a variant subtype of DCIS but a recent review of literature shows its association with DCIS or invasive breast cancer in about 40% cases [5]. In IPC (pure) form, solid papillary tumor is confined within a cystic dilated duct without DCIS or invasion into the surrounding tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically EPC is characterized by papillary configuration within a well-circumscribed cystic or distended duct with cytological features similar to papillary DCIS. These lesions lack myoepithelial cells at their periphery, in contact to DCIS which exhibits myoepithelial cell at the periphery; recently many authors have considered EPCs as, invasive carcinomas with an expansile growth [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Unusual Case of High Grade Triple Negative Intracystic Solid Papillary Carcinoma of Breast with Invasive Component

Junainah¹,

Baslaim²,

Shigairi³

et al. 2017

J Clin Exp Pathol

View full text Add to dashboard Cite

Background: Intracystic (encysted) papillary carcinoma (IPC) is a rare distinct entity of breast cancer, usually asymptomatic, sometimes presented as breast mass or nipple discharge. It shows benign appearance on imaging. Ultrasonography shows pure cyst or mixed image, sometime solid mass. Pathologically can be divided into pure form, or associated with ductal carcinoma in situ (DCIS) or invasive carcinoma. It is considered as noninvasive or minimally invasive, because there is no infiltrating growth pattern and metastases are rare. Traditionally considered to lack a myoepithelial layer, it has favorable prognosis even with invasion. Stromal invasion found in 92%. In case of high grade variant which diagnosed by high nuclear grade and high mitotic activity, usually triple negative and p53+ as we have in our case?

show abstract

Breast Intracystic Papillary Carcinoma: An Update

Cited by 41 publications

References 35 publications

8p deletion is strongly linked to poor prognosis in breast cancer

8p deletion is strongly linked to poor prognosis in breast cancer

Intracystic Carcinoma of the Breast: Report of Two Cases

An Unusual Case of High Grade Triple Negative Intracystic Solid Papillary Carcinoma of Breast with Invasive Component

Contact Info

Product

Resources

About