Breast Inflammatory Gigantomastia in a Context of Immune-Mediated Diseases

Abstract

We suggest that breast tissue may be a target tissue in autoimmune diseases, this process being favored by the hormonal milieu. However, the precise mechanism of such association is not individualized. The fact that stromal hyperplasia is the main histological feature justifies the search for the involvement of growth factors in such a process.

Bilateral Gigantomastia, Multiple Synchronous Nodular Pseudoangiomatous Stromal Hyperplasia Involving Breast and Bilateral Axillary Accessory Breast Tissue, and Perianal Mammary-Type Hamartoma of Anogenital Mammary-Like Glands

“…27 Some cases of gestational gigantomastia were observed in women with myasthenia gravis. 28,29 The association between gigantomastia and treatment with bucillamine, autoimmune and endocrine disorders has been noted previously for juvenile hypertrophy in the nonpregnancy setting. 23,[29][30][31] Rare cases of familial gigantomastia are described but there is no specific recorded association with facioscapulohumeral dystrophy.…”

“…28,29 The association between gigantomastia and treatment with bucillamine, autoimmune and endocrine disorders has been noted previously for juvenile hypertrophy in the nonpregnancy setting. 23,[29][30][31] Rare cases of familial gigantomastia are described but there is no specific recorded association with facioscapulohumeral dystrophy. [32][33][34] In our case, microscopic examination of both enlarged breasts revealed prominent fibrous mastopathy characterized by almost complete replacement of the stromal adipose tissue of the breast by dense acellular fibrous tissue ( Fig.…”

Gigantomastia gestacional: relato de caso e revisão bibliográfica

“…Casos associados ao lúpus eritematoso sistêmico, ao pseudo-hiperparatireoidismo e aos linfomas têm sido reportados. Deste modo, devem ser realizados: hemograma completo, provas de função hepática, eletrólitos e perfi l hormonal [9][10][11] . O quadro clínico se caracteriza por aumento maciço, desproporcional em mamas, geralmente bilateral.…”

Bilateral Breast Enlargement and Reddish Skin Macules as First Signs of Acute Lymphoblastic T Cell Leukemia

“…Further, autoimmune diseases, e.g. systemic lupus erythematodes, Hashimoto's thyreoiditis, psoriasis, or myasthenia gravis, can be accompanied by breast enlargement [23,24]. Penicillamine treatment, which is known to cause autoimmune side effects, can also result in breast enlargement [25].…”