Breast implants in patients with differentiated and undifferentiated connective tissue disease

Hj, Williams; Mh, Weisman; Cc, Berry

doi:10.1002/art.1780400308

Cited by 28 publications

(9 citation statements)

References 22 publications

(15 reference statements)

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“…Undifferentiated CTD was accepted by the authors as the term for atypical CTD because it has a clear case definition, is distinct from the other established CTDs, and has substantive symptoms. 61 Lipworth et al 41 performed an updated review of the results of epidemiologic studies published since 1999 2,55,62-66 and concluded that the results of several studies provide no evidence of a higher frequency of undefined CTD among women with cosmetic breast implants or of a rheumatic symptom profile unique to these women and/or indicative of a specific atypical CTD.…”

Section: Breast Cancer Detectionmentioning

confidence: 97%

The Safety of Silicone Gel-Filled Breast Implants

McLaughlin

Lipworth²,

Murphy³

et al. 2007

Annals of Plastic Surgery

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Few implantable medical devices have been studied for their safety more extensively than silicone gel-filled breast implants. We summarize the epidemiologic evidence on the safety of breast implants, most of which is drawn from large cohort studies with long-term follow-up. The topics addressed in this report include cancer, breast cancer detection, connective tissue disease, suicide, offspring effects, neurologic disease, implant rupture, and local perioperative complications and additional surgery. We conclude that the weight of the epidemiologic evidence does not support a causal association between breast implants and breast or any other type of cancer, definite or atypical connective tissue disease, adverse offspring effects, or neurologic disease. Women with breast implants do not present with more advanced stages of breast cancer or suffer impaired survival after breast cancer diagnosis. The only study to examine an actual incidence rate of breast implant rupture reported rupture-free survival of 98% at 5 years and 83%-85% at 10 years for newer "third-generation" implants. Future studies are needed to determine whether the consistently observed excess of suicide among women with implants reflects underlying psychiatric illness prior to breast augmentation surgery or other factors.

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Section: Breast Cancer Detectionmentioning

confidence: 97%

The Safety of Silicone Gel-Filled Breast Implants

McLaughlin

Lipworth²,

Murphy³

et al. 2007

Annals of Plastic Surgery

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“…between silicone breast implants and CTD have been published. [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] All [22][23][24][25][26][27][28][29][30][31][32][33][35][36][37][38][39][40] but one 34 have failed to demonstrate an increased risk of systemic sclerosis or any other CTDs. The one study 34 that found a small, but significant, excess of CTD was based on self-reporting of diseases, the subsequent validation of reported CTDs found evidence for overreporting, as only 22.7% of the self-reported cases could be confirmed.…”

Section: Original Investigationmentioning

confidence: 99%

Connective Tissue Disease and Other Rheumatic Conditions Following Cosmetic Breast Implantation in Denmark

Kjøller

Friis²,

Mellemkjær³

et al. 2001

Arch Intern Med

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The findings of this study support previous investigations and independent review panel conclusions that an association between silicone breast implants and definite CTDs is unlikely. The observation of an excess of unspecified rheumatism among women with implants and among control women suggests that women undergoing cosmetic plastic surgery have hospitalization rates for this condition in excess of those from the general population.

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“…Although many aspects of the local immune response to silicone have been elucidated, it is still unclear whether women with silicone breast implants experience a systemic activation of their immune systems. Several studies showed increased prevalence of serologic markers of connective tissue diseases such as rheumatoid arthritis, systemic lupus erythematosus, mixed connective tissue disease, polymyositis or scleroderma [9][10][11], but even metaanalyses have not provided an unequivocal link between SMI and systemic autoimmune diseases [12,13]. In contrast to these metaanalyses, there are numerous case reports of SMI patients showing defined rheumatologic disorders that were greatly ameliorated by implant removal [14].…”

Section: Introductionmentioning

confidence: 98%