2021
DOI: 10.1016/j.clml.2020.12.005
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon lymphoproliferative disorder, mainly associated with textured implants. The average time from the breast implants to the development of BIA-ALCL is about 7 to 10 years, and the median age at the time of diagnosis is in the mid-50s. The exact incidence and prevalence of BIA-ALCL are not known. The pathogenesis of BIA-ALCL remains unclear. Different theories have been postulated, including immune response to textured implants, sub… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
4
0

Year Published

2022
2022
2022
2022

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 4 publications
(4 citation statements)
references
References 44 publications
(43 reference statements)
0
4
0
Order By: Relevance
“…In those people who have a genetic predisposition to the disease, the shell particle of the textured implants causes chronic T cell and phagocytic cellular aggregation, which results in chronic inflammation and immunological dysregulation. This collection of T cells might be in close proximity to the silicone substance, which may eventually cause them to become sensitive to particles composed of silicones or their subsequent proteins, triggering a response to the antigen and its presentation in T cells [ 26 ]. Monocytes and T lymphocytes are mainly infiltrated close to the surface of biomaterials, where they release IL-4, IL-13, and other substances as a result [ 6 , 27 ].…”
Section: Reviewmentioning
confidence: 99%
See 2 more Smart Citations
“…In those people who have a genetic predisposition to the disease, the shell particle of the textured implants causes chronic T cell and phagocytic cellular aggregation, which results in chronic inflammation and immunological dysregulation. This collection of T cells might be in close proximity to the silicone substance, which may eventually cause them to become sensitive to particles composed of silicones or their subsequent proteins, triggering a response to the antigen and its presentation in T cells [ 26 ]. Monocytes and T lymphocytes are mainly infiltrated close to the surface of biomaterials, where they release IL-4, IL-13, and other substances as a result [ 6 , 27 ].…”
Section: Reviewmentioning
confidence: 99%
“…A research study of whole exome sequencing performed on DNA extracted from cytology fluid and germline DNA of two patients with effusion-limited BIA-ALCL revealed mutations in JAK1 and STAT3 as well as a germline JAK3 mutation, the latter of which suggested a potential genetic susceptibility for the development of this lymphoma [ 28 , 29 ]. Chronic inflammation brought on by the ongoing processing of antigens may result in immunological dysregulation, cell proliferation, formation of foreign body giant cells (FBGCs) with a higher chance of genetic mutation, and ultimately cancer (Figure 1 ) [ 26 ].…”
Section: Reviewmentioning
confidence: 99%
See 1 more Smart Citation
“…Although the exact pathogenesis of BIA-ALCL is unclear, one hypothesis is that inflammatory cell aggregation induced by textured implants leads to immune dysregulation and cell proliferation. [ 3 ]…”
mentioning
confidence: 99%