Breast Implant Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)

Perry, Luke; Radzevich, Joseph; Kelter, David; Gott, Melissa; Slotman, Gus J.; Kulkarni, Nandini; Gundlapalli, Vinay

doi:10.1177/0003134820951422

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…Similar to other anaplastic lymphoma kinase (ALK)-negative ALCL (i.e. systemic and primary cutaneous), BIA-ALCL is composed by large anaplastic tumor cells strongly positive for CD30 and commonly for CD4 and cytotoxic markers, but negative or only occasionally positive for other T-cell associated markers such as CD3, CD5, CD7, and CD8 [ 24 , 25 ]. Despite the morphologic similarities, its distinction from the other types of ALK-negative ALCL is based on both clinical and molecular characteristics [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical recommendations for diagnosis and treatment according to current updated knowledge on BIA-ALCL

Longo

Napoli²,

Curigliano³

et al. 2022

The Breast

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Section: Discussionmentioning

confidence: 99%

Clinical recommendations for diagnosis and treatment according to current updated knowledge on BIA-ALCL

Longo

Napoli²,

Curigliano³

et al. 2022

The Breast

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“…It was first described by Keech and Creech (1997) as a T-cell lymphoma in proximity to a saline-filled breast implant. The cells were reported to be CD2, CD4, CD30, and CD56 positive and negative for CD7, CD8, TCL1, EBER (Epstein–Barr coding region), and ALK (anaplastic lymphoma kinase) (Srinivasa et al ., 2017; Perry et al ., 2022). In 2016, the WHO admitted BIA-ALCL as a possible long-term complication of breast implants (Swerdlow et al ., 2016), and in 2017, this variant p T-cell lymphoma was included in the classification of lymphoid neoplasms.…”

Section: Introductionmentioning

confidence: 99%

BIA-ALCL in patients with genetic predisposition for breast cancer: our experience and a review of the literature

Carbonaro

Accardo

Mazzocconi

et al. 2023

European Journal of Cancer Prevention

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Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an emerging non-Hodgkin’s lymphoma that occurs exclusively in patients with breast implants. The estimated risk of developing BIA-ALCL from exposure to breast implants is largely based on approximations about patients at risk. There is a growing body of evidence regarding the presence of specific germline mutations in patients developing BIA-ALCL, rising interest regarding possible markers of genetic predisposition to this type of lymphoma. The present paper focuses attention on BIA-ALCL in women with a genetic predisposition for breast cancer. We report our experience at the European Institute of Oncology, Milan, Italy, describing a case of BIA-ALCL in a BRCA1 mutation carrier who developed BIA-ALCL 5 years after implant-based post mastectomy reconstruction. She was treated successfully with an en-bloc capsulectomy. Additionally, we review the available literature on inherited genetic factors predisposing to the development of BIA-ALCL. In patients with genetic predisposition to breast cancer (mainly TP53 and BRCA1/2 germline mutations), BIA-ALCL prevalence seems to be higher and time to onset appears to be shorter in comparison to the general population. These high-risk patients are already included in close follow-up programs allowing the diagnosis of early-stage BIA-ALCL. For this reason, we do not believe that a different approach should be followed for postoperative surveillance.

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“…It was first described by Keech and Creech in 1997 [ 2 ] as a t-cell lymphoma with specific clusters of differentiation. It has been reported as CD 2, 4, 30 and 56 positive and negative for CD 7, 8, TCL1 (tumor cell lysate), EBER (Epstein–Barr encoding region) and ALK (anaplastic lymphoma kinase) [ 3 , 4 ]. Common symptoms are pain, breast swelling, asymmetry, redness, delayed seroma, and solid tumor.…”

Section: Introductionmentioning

confidence: 99%

“…Despite many years of research, the etiopathogenetic mechanisms responsible for it remain poorly understood [ 1 , 15 , 16 , 17 , 18 , 19 ]. Many researches theorize a role of bacterial biofilm around the implant: this leads to chronic inflammation and, successively, to capsule contracture [ 3 ] and/or BIA-ALCL. The link between biofilm, chronic inflammatory response and BIA-ALCL is not the only mechanism proposed: the roles of personal characteristics and mechanical stimulations has been described by many researchers in the world.…”

Section: Introductionmentioning

confidence: 99%

The State of the Art about Etiopathogenetic Models on Breast Implant Associated–Anaplastic Large Cell Lymphoma (BIA-ALCL): A Narrative Review

Cuomo

2021

JCM

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Background: Breast-implant-associated anaplastic large cell lymphoma is a rare malignancy linked to texturized breast implants. Although many researchers focus on its etiopathogenesis, this topic is affected by a lack of evidence. Materials and Methods: A literature review about BIA-ALCL was made. Results and conclusions: Although the incidence is reported between 1:355–1:30,000, there is great attention to BIA-ALCL. The incidence is uncertain due to many reasons. It may well be lower, due to inclusion in multiple databases as pointed out by the FDA and undiagnosed cases. The role of chronic inflammation, bacterial contamination, and mechanical forces was discussed. Clarification is needed to understand the mechanisms underlying the progression of alterations and mutations for BIA-ALCL; new molecular analysis and pathogenetic models should be investigated.

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Breast Implant Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)

Cited by 3 publications

References 4 publications

Clinical recommendations for diagnosis and treatment according to current updated knowledge on BIA-ALCL

Clinical recommendations for diagnosis and treatment according to current updated knowledge on BIA-ALCL

BIA-ALCL in patients with genetic predisposition for breast cancer: our experience and a review of the literature

The State of the Art about Etiopathogenetic Models on Breast Implant Associated–Anaplastic Large Cell Lymphoma (BIA-ALCL): A Narrative Review

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