Breast Hamartoma: a Case Report

Barbaros, Umut; Deveci, Uğur; Erbil, Yeşim; Budak, Demir

doi:10.1080/00015458.2005.11679798

Cited by 12 publications

(10 citation statements)

References 8 publications

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“…However, as MHs are very rare breast lesions, it is of interest for clinical practice to carry out a detailed histopathological description and subsequent follow-up of these patients to achieve as much information as possible about the biological behaviour of these breast Discussion MH was described for the first time in 1973 by Davies and Riddell [10]. Its exact incidence is not yet known as there have not been more than 35 cases of MH described in the literature, mainly as case reports [2][3][4][5][6][7][9][10][11][12][13][14][15][16][17][18][19][20]. The aetiopathogenesis of MH remains unclear, although there is a probable impact of female steroid hormones on cellular growth as all cases except one occurred in women [19].…”

Section: Case Reportmentioning

confidence: 99%

Myoid (Muscular) Hamartoma of the Breast: Case Report and Review of the Literature

Kajo¹,

Žúbor

Danko³

2010

Breast Care

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Background: Myoid (muscular) hamartoma (MH) of the breast is a rare benign tumour-forming lesion composed of differentiated mammary glandular and stromal structures, fatty tissue, and areas of smooth muscle. It is considered to be a variant of mammary hamartoma. Case Report: We report the case of a 46-year-old woman with MH, and provide a literature review explaining the origin of smooth muscle cells. Histologically, the tumour consisted of fibrolipomatous stroma containing ductal and lobular structures of the mammary gland located mainly at the tumour borders. The glandular structures showed signs of micro- and macrocystic changes, apocrine metaplasia, and adenosis. The dominant feature was the presence of a fascicular formation of spindle cells, predominantly in central parts, with incursion between glandular structures. Immunohistochemically, foci of smooth muscle tissue were positive for desmin, smooth muscle actin, and h-caldesmon. Oestrogen and progesterone receptors (PR) showed positive expression which was markedly higher for PR. There was negative expression of CD34, S-100 protein, and CD10. Conclusions: The origin of smooth muscle cells in MH is unknown. However, it is presumed to be derived from hormonally responsive breast stromal cells by smooth muscle metaplasia, based on evidence of hormone receptor expression in the lesion.

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Section: Case Reportmentioning

confidence: 99%

Myoid (Muscular) Hamartoma of the Breast: Case Report and Review of the Literature

Kajo¹,

Žúbor

Danko³

2010

Breast Care

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“…In addition, the absence of axillary adenomegaly, a criterion of benignity noted in our patient has also been reported [1] [12]. Some bilateral forms have been described [7]. The onset of signs can range from two months to two years [7] before diagnosis or even more as in our patient with a chronic course in thirty years marked by painful episodes during pregnancy.…”

Section: Discussionmentioning

confidence: 72%

“…Some bilateral forms have been described [7]. The onset of signs can range from two months to two years [7] before diagnosis or even more as in our patient with a chronic course in thirty years marked by painful episodes during pregnancy. This is a particular character emphasized by this radio-clinical case; late use of appropriate care is an African trait.…”

Section: Discussionmentioning

confidence: 99%

Giant Breast Hamartoma: A Case Report in Togo

N’timon¹,

Darré²,

Dagbe³

et al. 2018

OJRad

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We report the case of a 50-year-old patient, who was explored in mammography, ultrasound and CT for a large painful mass of the right breast that had been evolving for 30 years and gradually increasing in size. There was a typical "sausage slice" appearance with clear center macrocalcifications on the mammogram; an aspect of "breast in the breast" on ultrasound. The scanner had made it possible to specify the dimensions of the mass, which measured 21.4 cm in height; 18.6 cm wide and 9.5 cm thick. Histology after exeresis noted the adenolipofibromatous nature of the mass.

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“…Although hamartomas are benign, coincidental malignancy may occur. Therefore, surgical removal is the curative treatment for breast hamartomas (11,12). The patient in the present study underwent a partial mastectomy in order to achieve a tumor-free margin.…”

Section: Discussionmentioning

confidence: 99%

“…Breast hamartomas are rare lesions, that may be misdiagnosed pre-operatively, with a definitive diagnosis made by histological examination. As a hamartoma has the potential to progress to breast cancer (3–10), surgical removal is the curative treatment for breast hamartomas (11,12). The patient provided written informed consent.…”

Section: Introductionmentioning

confidence: 99%

Myoid hamartoma of the breast with focal chondromyoxid metaplasia and pseudoangiomatous stromal hyperplasia: A case report

Chen

Kuo

et al. 2015

Oncology Letters

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Hamartomas of the breast, also known as fibroadenolipomas, lipofibroadenomas or adenolipomas, are benign lesions. Hamartomas account for between 0.04 and 1.15% of all benign breast tumors in females. Myoid hamartoma of the breast (MHB) is extremely rare. The present study describes a case of MHB in a 44-year-old female. Screening mammography revealed a lobulated partial indistinct isodense mass measuring ~3.8 cm in the upper outer quadrant of the left breast. Sonographic examinations revealed a 2–3-cm mass in the left breast, which was fairly well circumbscribed and demonstrated complex scattered echogenic areas and isoechoic tissue. A core needle biopsy demonstrated fibrocystic changes, with small focal ductule aggregations. As malignancy could not be excluded, a partial mastectomy was performed using a circumareolar incision. The mass was histopathologically diagnosed as MHB with focal chondromyoxid metaplasia and pseudoangiomatous stromal hyperplasia. The histological diagnosis was based upon the findings of the well-circumscribed tumor, which was composed of entrapped mammary ducts, fat cells and myoid stromal components, with focal chondromyxoid metaplasia and pseudoangiomatous stromal hyperplasia. The tumor cells exhibited diffuse cluster of differentiation 34-positive immunoreactivity, which was consistent with a diagnosis of pseudoangiomatous stromal hyperplasia.

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Breast Hamartoma: a Case Report

Cited by 12 publications

References 8 publications

Myoid (Muscular) Hamartoma of the Breast: Case Report and Review of the Literature

Myoid (Muscular) Hamartoma of the Breast: Case Report and Review of the Literature

Giant Breast Hamartoma: A Case Report in Togo

Myoid hamartoma of the breast with focal chondromyoxid metaplasia and pseudoangiomatous stromal hyperplasia: A case report

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