Breast fibromatosis, an unusual breast disease

Abdelwahab, Khaled; Hamdy, Omar; Zaky, Mona; Megahed, Nirmeen; Elbalka, Saleh S.; Elmetwally, Mohamed; Denewer, Adel

doi:10.1093/jscr/rjx248

Cited by 8 publications

(7 citation statements)

References 11 publications

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“…Our patient showed no skin retraction. The immunohistochemistry exam shows positivity for β-catenin in 70% of cases [7]. In the present case, the follow-up at 2 years showed the recurrence of the lesion.…”

Section: Discussionsupporting

confidence: 54%

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Desmoid Tumor of the Breast as a Manifestation of Gardner’s Syndrome in an Elderly Woman: A Case Report and Review of Literature

Zoukar¹,

Khaskhoussy²,

Hammami³

et al. 2018

CRCM

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Desmoid tumor of the breast is an extremely rare entity. Histologically, it corresponds to a benign fibroblastic proliferation of a local evolution, with a high recurrence potential. We report the first case of elderly woman presented with desmoid-tumor of the breast as a manifestation of Gardner's syndrome. A brief literature review was provided. We report the case of a 72-year-old woman who presented with five months history of painful and an exophytic mass of her left breast. She is known to have familial polyposis and had a total colectomy with Gardner's syndrome. She had a history of osteomas of the maxilla. On clinical examination, there was an exophytic painless mass, on the upper medial quadrant of the breast. She had also lipoma in the left leg and pigmented skin lesions in legs. Her mammograms showed a suspicious stellar image. A computed tomography scan showed an ovoid lesion. Excision of the lesion was performed. Histopathology confirms a desmoid-tumor of the breast. Evolution was marked by lesion recurrence. In conclusion, desmoid tumor of the breast is rare, non-metastatic but locally aggressive. Clinical expression is often nonspecific. Treatment remains controversial; surgical excision is the treatment of choice.

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Section: Discussionsupporting

confidence: 54%

“…. Most of these cases were reported in young and fertile women with rare cases in male patients[7] [8]. Glazebrook KN et al reported an extensive study of 125 cases of mammary fibromatosis (114 women and 11 men).…”

mentioning

confidence: 99%

Desmoid Tumor of the Breast as a Manifestation of Gardner’s Syndrome in an Elderly Woman: A Case Report and Review of Literature

Zoukar¹,

Khaskhoussy²,

Hammami³

et al. 2018

CRCM

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“…Mediante técnicas de imagen (ecografía, mamografía y/o resonancia magnética), en ambos casos se obtuvieron imágenes compatibles con cáncer de mama, por lo que fue necesario el estudio anatomopatológico para alcanzar el diagnóstico de fibromatosis, al visualizar una proliferación de células fusiformes entre un denso estroma colagenizado, con moderada celularidad, sin atipia nuclear ni figuras de mitosis. Destacar el importante papel de la inmunohistoquímica usualmente positivo para vimentina, actina del músculo liso y beta catenina (esta última en un 70-80% de los casos), 9 pero generalmente negativo para la desmina, las citoqueratinas, el CD34 y la S-100 10 , características que cumplen nuestras dos pacientes.…”

Section: Discussionunclassified

Fibromatosis mamaria. Reporte de dos casos clínicos y revisión bibliogáfica

Álvarez

Sánchez-Méndez

et al. 2019

Rev. chil. obstet. ginecol.

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Calle Jesús del Valle nº15 4ºA1, 28004 Madrid. RESUMENIntroducción y objetivos: La fibromatosis produce tumores benignos pero localmente agresivos, que afectan a los tejidos blandos. A nivel mamario, representa tan sólo el 0.2% de las neoplasias de la mama. Nuestro objetivo con el presente artículo es profundizar en el conocimiento de la fibromatosis mamaria, a través del estudio de dos casos clínicos, mostrando sus características clínico-radiológicas e histológicas, e intentar establecer un protocolo de actuación adecuado. Métodos: Estudio retrospectivo de dos casos clínicos de fibromatosis mamaria diagnosticados en el Hospital Universitario La Paz entre los años 2018 y 2019. Resultados: Presentaremos dos pacientes con diagnóstico de fibromatosis mamaria, ambas debutaron con la autopalpación de un nódulo mamario. Al realizarles una ecografía, se visualizó un nódulo sólido, mal definido y axila ecográficamente negativa, que precisó de biopsia-aspiración con aguja gruesa. En los dos casos, se decidió resección quirúrgica de la lesión. Seguimiento mediante exploración mamaria y pruebas de imagen periódicas. Conclusiones: Aunque se trata de una entidad benigna, la fibromatosis mamaria puede simular un proceso maligno, tanto clínica como radiológicamente, por lo que precisa de un estudio histológico. A pesar de que la diseminación metastásica es muy poco frecuente, no se debe olvidar el carácter agresivo a nivel local de esta patología, y sus altas tasas de recurrencia. Como tratamiento, se debe realizar una resección quirúrgica, aunque recientemente se ha contemplado la opción de vigilancia estrecha sin tratamiento. No existe evidencia científica que justifique la utilización de otros tratamientos como la radioterapia o el tratamiento hormonal. PALABRAS CLAVE:Fibromatosis, tumor desmoide, nódulo mamario.ABSTRACT REV CHIL OBSTET GINECOL 2019; 84(5): 384 -392 385

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“…Focal prominent stromal collagen was demonstrated. The diagnosis of fibromatosis was supported by positive nuclear staining with β-catenin, which is seen in 70–80% of cases [ 6 ]. Our tumor did not show any p63 positivity, which would have supported the diagnosis of spindle cell carcinoma.…”

Section: Case Reportmentioning

confidence: 99%

“…The diagnosis of breast DF can be difficult to determine preoperatively, and is often mistaken for carcinoma due to appearance on imaging and clinical presentation [ 1 ]. Breast fibromatosis lack metastatic potential but are locally aggressive with high rates of recurrence despite adequate excision [ 1 , 2 , 5 , 6 ]. They can develop from fibroblasts or myofibroblasts in the breast parenchyma, the musculoaponeurotic layer of the pectoralis muscle, or in association with the capsule that forms around a breast implant [ 2 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Silicone breast implant associated fibromatosis

Hill

Merrill

Korourian

et al. 2018

Journal of Surgical Case Reports

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Extra-abdominal desmoid tumors, also known as aggressive or deep fibromatosis, are uncommon soft tissue tumors that rarely involve the breast. Although the exact etiology is unknown, the development of these tumors has been correlated with sites of previous trauma, surgery or in association with familial adenomatous polyposis. Clinically, breast fibromatosis is often mistaken for carcinoma but lacks metastatic potential. It is locally aggressive with high rates of recurrence. The treatment is primarily wide local excision with negative margins. Adjuvant treatments have been suggested and include radiotherapy, chemotherapy and hormonal therapy, however, there are no evidence-based treatment protocols to support their use. Here, we describe a case of fibromatosis that developed within the capsule around a silicone breast implant treated with surgical excision alone. The patient remains recurrence free at 3 months post-operative magnetic resonance imaging.

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Breast fibromatosis, an unusual breast disease

Cited by 8 publications

References 11 publications

Desmoid Tumor of the Breast as a Manifestation of Gardner’s Syndrome in an Elderly Woman: A Case Report and Review of Literature

Desmoid Tumor of the Breast as a Manifestation of Gardner’s Syndrome in an Elderly Woman: A Case Report and Review of Literature

Fibromatosis mamaria. Reporte de dos casos clínicos y revisión bibliogáfica

Silicone breast implant associated fibromatosis

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