Breast density quantification using structured-light-based diffuse optical tomography simulations

Ruiz, Jessica; Nouizi, Farouk; Cho, Jaedu; Zheng, Jie; Li, Yifan; Chen, Jeon‐Hor; Su, Min‐Ying; Gülşen, Gültekin

doi:10.1364/ao.56.007146

Cited by 18 publications

(13 citation statements)

References 57 publications

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“…The authors have noted that the distribution of the examined compound concentrations significantly differed in each clinical case. In the other research [86] in which the value of DOS in the diagnosis of breast pathology was compared with MRT, the results were comparable.…”

Section: Diffuse Optical Spectroscopymentioning

confidence: 73%

Current Methods for the Assessment of Oxygen Status and Biotissue Microcirculation Condition: Diffuse Optical Spectroscopy (Review)

Бесчастнов¹,

Ryabkov²,

Pavlenko³

et al. 2018

Sovrem Tehnol Med

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The problem of studying the oxygen status and biotissue microcirculation is of special interest for many directions in medical science since one of the causes of hypoxia development as a typical pathophysiological process is a microcirculatory "failure" associated with the impairment of normal anatomy of the capillary wall, changes in the rheological blood properties, acceleration or slowdown of the blood flow. Current imaging techniques enable the researchers to study the processes of biosystem vital activity at various levels: from organs and tissues to the substance molecular composition. Methods of functional bioimaging implemented into clinical practice provide the opportunity of watching online the processes of substance movement in the body, monitoring blood flow parameters, assessing hypoxia level, characterizing metabolism in greater detail, and, at the same time, correcting timely pathological conditions. The main advantages and disadvantages of bioimaging examination methods such as BOLD functional magnetic resonance tomography, positron emission tomography, optical imaging, laser Doppler flowmetry, and transcutaneous oximetry are considered in the present review. Special attention is paid to diffuse optical spectroscopy as a noninvasive method of lifetime study of substance content in biotissues. The principle of diffuse optical spectroscopy is based on the ability of tissue chromophores (oxyhemoglobin, deoxyhemoglobin, fatty acids, collagen) to absorb diffusely scattered light of a definite wavelength. Their concentrations are calculated with the allowance for the absorption coefficients of chromophores. Diffuse optical spectroscopy is being introduced in clinical practice to diagnose the degree of tumor malignization, evaluate vascularization in reconstructive operations, diagnose hypoxic tissue conditions, monitor intraoperatively blood flow parameters, measure hypoxia levels in diabetes mellitus. It provides the possibility to define and make clear indications to skin plastic surgery and, conceivably, to develop new methods of skin plasty.

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Section: Diffuse Optical Spectroscopymentioning

confidence: 73%

Current Methods for the Assessment of Oxygen Status and Biotissue Microcirculation Condition: Diffuse Optical Spectroscopy (Review)

Бесчастнов¹,

Ryabkov²,

Pavlenko³

et al. 2018

Sovrem Tehnol Med

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“…In addition, Blackmore et al correlated breast tissue optical content (water, lipid and StO 2 ) with percent density in pre-and post-menopausal women [21]. In a simulation study, Ruiz et al found that estimated percent breast density predicted from lipid and water maps was highly correlated to the true values from MRI [22]. Moreover, Fang et al found linear correlation between ctTHb and the fibroglandular volume fraction derived from the 3D digital breast tomosynthesis imaging scans [23].…”

Section: Discussionmentioning

confidence: 99%

Diffuse optical tomography of the breast: a potential modifiable biomarker of breast cancer risk with neoadjuvant chemotherapy

Altoé¹,

Marone²,

Kim³

et al. 2019

Biomed. Opt. Express

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The purpose of this study is to evaluate whether a diffuse optical tomography breast imaging system (DOTBIS) can provide a comparable optical-based image index of mammographic breast density, an established biomarker of breast cancer risk. Oxyhemoglobin concentration (ctO 2 Hb) measured by DOTBIS was collected from 40 patients with stage II-III breast cancer. The tumor-free contralateral breast was used for this evaluation. We observed a moderate positive correlation between the patient's mammogram density classification and ctO 2 Hb, r s = 0.486 (p = 0.001). In addition, significant reduction in ctO 2 Hb levels were noted during neoadjuvant chemotherapy treatment (p = 0.017). This observation indicates that ctO 2 Hb levels measured by DOTBIS could be a novel modifiable imaging biomarker of breast cancer risk and warrants further investigation.

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“…But on the trail, they are walking, nature does not give any better opportunity to take progressive steps. Hence, they have changed their focus into mathematical short‐cut methods 13‐32 …”

Section: Introductionmentioning

confidence: 99%

Differential photon waves imaging

Kazancı

2020

Int J Imaging Syst Tech

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Imaging philosophy was simulated for well‐known biomedical diffuse optical imaging (DOI) methodology. It runs based on the differential photon waves. The underlying philosophy of imaging methodology takes its origin from the distance of the same molecule types. Inherently, each type of biological molecules has different molecular structure, size, and binding distance. Molecules might be water, oxy‐hemoglobin, deoxyhemoglobin, ATP, pepsin, cholesterol, protein, fats or lipids, hydroxyapatite, carbohydrates, glucose, glycogen, DNA, etc. These molecules need to be grouped for biomedical photon imaging purposes such as in hair, skull, scalp, cortex, dermis, epidermis, cerebrospinal fluid, cerebellar gray and white matter for neuroimaging; or skin, fat, water for breast imaging; optic nerve, humor aqueous for eye imaging; bones and joints for skeletal system imaging; liver, muscle, fibroadenoma breast, mucous tissue, nodule, bowel, heart, kidneys, lung, stomach, whole blood vascular system for inner organs. Among these different types of molecular structures, each type has different characteristic photon absorption and scattering coefficients for corresponding wavelength. Researchers have been using these characteristic wavelengths to reconstruct the images. They have focused on either absorption or scattering maximums of specific wavelengths for each tissue type. This is right when the molecules are investigated first, but it is a dead‐end when it goes deep tissue, since low‐power laser photons scatter randomly when they penetrate inside the tissue, immediately. Novel approach uses phase‐shifted group photon waves corresponding to the molecular distances. Single photon wavelength can be used to investigate the molecules inside the imaging media.

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Breast density quantification using structured-light-based diffuse optical tomography simulations

Cited by 18 publications

References 57 publications

Current Methods for the Assessment of Oxygen Status and Biotissue Microcirculation Condition: Diffuse Optical Spectroscopy (Review)

Current Methods for the Assessment of Oxygen Status and Biotissue Microcirculation Condition: Diffuse Optical Spectroscopy (Review)

Diffuse optical tomography of the breast: a potential modifiable biomarker of breast cancer risk with neoadjuvant chemotherapy

Differential photon waves imaging

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