Breast conserving therapy is associated with improved overall survival compared to mastectomy in early-stage, lymph node-negative breast cancer

Does Mastectomy Reduce Overall Survival in Early Stage Breast Cancer?

“…The three largest studies (n ¼ 473 488) found BCSS benefit with BCS observed in the over 50 years group [27,37,43], with other studies confirming advantageous overall survival with BCS consistent across all age strata [31,32,36].…”

“…higher likelihood of recurrence (overall survival 88.4% BCS versus 82.5% mastectomy; P < 0.001). Below 50 years, overall survival was similar for both groups (95% versus 95.1%) and not affected by recurrence score [43] (see Table 1).…”

“…In a recent analysis of 231 642 patients [43], the influence of oncotype recurrence score was assessed. At 7 years of follow-up, overall survival was higher with BCS (90% versus 85.2%; P < 0.001), but limited to those women over 50 years of age with a recurrence score >25, i.e.…”

Six-year experience of oncoplastic volume replacement using local perforator flaps

“…There is growing evidence that it may provide better oncological outcomes when compared to mastectomy, with recent studies showing significantly improved survival for BCS and radiotherapy compared to mastectomy for early breast cancer, 1,2 particularly in women over 50 years of age. 3 Oncoplastic surgery helps extend the indication for breast conservation by facilitating safe wide excision whilst minimising long term aesthetic defects, with the aim of improved quality of life outcomes compared to traditional methods. 4 Studies have shown that oncoplastic procedures are oncologically safe, provide good aesthetic outcomes and do not delay adjuvant therapy.…”

Improved Survival after Breast-Conserving Therapy Compared with Mastectomy in Stage I-IIA Breast Cancer

“…The trials, conducted in the 1970s and 1980s, paved the way for the increased utilization of BCT for patients with stage I-II breast cancer [6]. Retrospective studies based on the analysis of large patient populations with early-stage breast cancer (EBC) treated in modern contexts indicate that BCT is at least comparable or even better in terms of breast-cancer-specific survival (BCSS) and OS compared to mastectomy without radiation therapy for early-stage breast cancer [7][8][9][10][11][12][13]. Improved DFS and OS rates were recently confirmed in smaller cohort studies [14][15][16][17][18][19][20] and were also observed in young women with EBC [21][22][23].…”