Breast-conserving surgery in breast cancer and intraoperative radiotherapy. Can we predict the fibrosis?

Bernad, Cristina Vallejo; Franco, María Carmen Casamayor; Ruiz, Jesús Víctor Pérez-Tierra; Lahoz, Yaiza Martínez; Puyal, Aurora Carrasquer; Segura, José Luis Pallarés; Marín, Juan Pelegrín Sánchez; Pardos, María Victoria Barra

doi:10.1016/j.cireng.2019.10.008

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…According to the results of previous studies, the serum level of TGF-β is an early marker for predicting brosis after surgery and before radiotherapy. The serum levels of TGF-β in patients who had undergone IORT after surgery were signi cantly higher than those of the patients that had only undergone breast-conserving cancer surgery, suggesting that this alteration in the TGF-β level was the outcome of IORT 34 .…”

Section: Discussionmentioning

confidence: 92%

The Effect of Intraoperative Radiotherapy on Breast Cancer: Focus on the Levels of Angiogenic Factors

Nafisi

Mohammadlou

Akbari

et al. 2021

Preprint

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Objective: Angiogenesis is one of the hallmarks of cancers that is involved in tumor progression. Angiogenic factors induce the formation of new blood vessels and tumor extension, and finally reduce the survival of patients. Intraoperative radiotherapy (IORT), in which radiation is delivered to the tumor bed can kill cells and change tumor microenvironment. Here, we compared the impact of IORT on the levels of angiogenic factors in the blood and surgical wound fluids (SWF) of the breast cancer patients. Patients and Methods: Blood and drained wound fluid (WF) samples were collected from the breast cancer patients before and after surgery, followed by quantification of the amounts of TGF-β, EGF, FGF, VEGF and DLL4 in the patients using ELISA.Results: Our results were indicative of significant differences between the pre-surgery and post-surgery serum levels of EGF, DLL4 and VEGF. In addition, linear regression analysis showed the significant impact of IORT, vascular invasion and lymph node (LN) involvement on the difference between TGF-β levels in the blood before and after surgery-IORT. According to the outcomes of multivariate analysis, IORT changed the levels of EGF and FGF in the blood and WF. Furthermore, logistic regression analyses showed that TGF-β and EGF can be used as predictor markers of the late-stage and LN involvement of the disease. Interestingly, IORT was able to reduce the risk of death and the recurrence rate of disease. Conclusions: In summary, IORT is a safe and effective treatment that can affect angiogenesis and improve the survival of breast cancer patients.

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Section: Discussionmentioning

confidence: 92%

The Effect of Intraoperative Radiotherapy on Breast Cancer: Focus on the Levels of Angiogenic Factors

Nafisi

Mohammadlou

Akbari

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…According to the results of previous studies, the serum level of TGF-β is an early marker for predicting fibrosis after surgery and before radiotherapy. The serum levels of TGF-β in patients who had undergone IORT after surgery were significantly higher than those of the patients that had only undergone breast-conserving cancer surgery, suggesting that this alteration in the TGF-β level was the outcome of IORT [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

The impact of intraoperative radiotherapy on breast cancer: focus on the levels of angiogenic factors

et al. 2022

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Objective Angiogenesis is one of the hallmarks of cancers that is involved in tumor progression. Angiogenic factors induce the formation of new blood vessels and tumor extension, and finally reduce the survival of patients. Intraoperative radiotherapy (IORT), in which radiation is delivered to the tumor bed can kill cells and change tumor microenvironment. Here, we compared the impact of IORT on the levels of angiogenic factors in the blood and surgical wound fluids (SWF) of the breast cancer patients. Patients and methods Three hundred sixty patients, who had undergone breast-conserving surgery between 2013 and 2018, were enrolled in IORT and non-IORT groups non-randomly. Blood and drained wound fluid (WF) samples were collected from the patients before and after surgery, followed by quantification of the amounts of TGF-β, EGF, FGF, VEGF, and DLL4 in the patients using ELISA. Results Our results were indicative of significant differences between the pre-surgery and post-surgery serum levels of EGF, DLL4, and VEGF. Furthermore, ROC analyses showed that TGF-β and DLL4 can differentiate of the early-stage from late-stage of the disease. Interestingly, the rate of the death and recurrence was reduced in IORT group. Conclusions In summary, IORT is a safe and effective treatment that can affect angiogenic factors and improve the overall- and recurrence-free survival of breast cancer patients.

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The comparison of transforming growth factor beta-1 serum levels in early-stage breast cancer patients treated with external beam whole breast irradiation plus boost versus interstitial brachytherapy accelerated partial breast irradiation

et al. 2022

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Breast-conserving surgery in breast cancer and intraoperative radiotherapy. Can we predict the fibrosis?

Cited by 3 publications

References 22 publications

The Effect of Intraoperative Radiotherapy on Breast Cancer: Focus on the Levels of Angiogenic Factors

The Effect of Intraoperative Radiotherapy on Breast Cancer: Focus on the Levels of Angiogenic Factors

The impact of intraoperative radiotherapy on breast cancer: focus on the levels of angiogenic factors

The comparison of transforming growth factor beta-1 serum levels in early-stage breast cancer patients treated with external beam whole breast irradiation plus boost versus interstitial brachytherapy accelerated partial breast irradiation

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