Breast Carcinomas With Choriocarcinomatous Features: Case Reports and Review of the Literature

Erhan, Yı́ldı́z; Özdemir, Necmettin; Zekioğlu, Osman; Nart, Denız; Çiriş, Metin

doi:10.1046/j.1524-4741.2002.08411.x

Cited by 31 publications

(66 citation statements)

References 8 publications

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“…The most plausible theory is being a metaplastic process within the primary tumor because it is well known that breast tumor cells often show metaplastic changes including osseous, chondroid, or matrix production. 1,3,5,6 Similar occurrence in other organs has also been hypothesized as possible collision tumors or secondary to a totipotential stem cell capable of epithelial and mesenchymal differentiation. 7 …”

Section: Histogenesismentioning

confidence: 80%

“…3,6,8 However, not all patients follow this fatal course and some may survive the disease. 1 A right side predilection has also been described. 1,6 PATHOLOGIC FINDINGS Tumor size ranges from 1 to 10 cm in the literature.…”

Section: Clinical Featuresmentioning

confidence: 98%

“…Patients present with a rapidly growing palpable breast mass that is clinically and radiologically indistinguishable from conventional types of breast carcinoma. 1,3,5,6,8 Patients are generally perimenopausal or postmenopausal, except for 2 reported cases of a 31-year-old patient and a 38-year-old pregnant woman. 3,6,8,9 Most patients present with locally advanced and/or metastatic disease and they die within 1 year of the diagnosis.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…1,6 PATHOLOGIC FINDINGS Tumor size ranges from 1 to 10 cm in the literature. 1,3,5,[8][9][10][11] The cut surface of the tumor is usually hemorrhagic and the tumor may display ill-defined infiltrative or wellcircumscribed margins.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…[1][2][3][4] Additionally, isolated carcinoma cells that are reactive immunohistologically for hCG can be found in 5% to 21% of ordinary infiltrating ductal carcinomas that do not exhibit choriocarcinomatous features. 5 The presence of occasional nonchoriocarcinomatous cells that are immunoreactive to hCG does not have any prognostic significance.…”

mentioning

confidence: 99%

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Carcinoma of the Breast With Choriocarcinomatous Features

Mohammadi

Rosa²

2011

Archives of Pathology &Amp; Laboratory Medicine

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Choriocarcinomatous differentiation has been described in tumors arising from many organs including lung, rectum, colon, stomach, bladder, and rarely breast. Mammary carcinoma with choriocarcinomatous features is a rare variant of breast metaplastic carcinoma characterized by malignant cells morphologically resembling choriocarcinoma cells in which reactivity with human placental lactogen and human chorionic gonadotropin can be demonstrated by immunohistochemistry. The characteristic syncytiotrophoblast-like giant cells seen in these neoplasms are more commonly associated with moderately to poorly differentiated carcinomas with or without a clear-cut mesenchymal component. Most of the reported cases have behaved very aggressively. The reason for this poor prognosis remains unclear. Because of the small number of cases, special treatment protocols have not been developed and these patients are treated surgically and with the standard chemotherapeutic agents available for other types of carcinoma of the breast. Pathologically, these tumors must be distinguished from metastatic choriocarcinoma to the breast.

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Section: Histogenesismentioning

confidence: 80%

Section: Clinical Featuresmentioning

confidence: 98%

Section: Clinical Featuresmentioning

confidence: 99%

Section: Clinical Featuresmentioning

confidence: 99%

mentioning

confidence: 99%

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Carcinoma of the Breast With Choriocarcinomatous Features

Mohammadi

Rosa²

2011

Archives of Pathology &Amp; Laboratory Medicine

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Fine-needle aspiration cytology of extramammary neoplasms metastatic to the breast

et al. 2005

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Fine-needle aspiration (FNA) biopsy is the first-line investigation in any breast lump and hence cytomorphological recognition of nonmammary metastatic tumors to the breast and their distinction from primary tumors is important. Metastatic breast neoplasms diagnosed over a 6-yr period from 1997 to 2002 were retrieved from the database of the Department of Cytopathology and the clinical, cytopathological, histochemical, and immunohistochemical findings were correlated with the histopathology of the primary tumor. Fifteen cases of metastatic breast neoplasms were encountered constituting 1.47% of all malignant tumors of the breast diagnosed on FNA. There were 14 female patients and one male patient aged 13-80 yr. The preaspiration clinical diagnosis was either a benign breast lump or a malignancy (primary vs. metastatic). The breast lump was the initial presentation in four cases and the cytodiagnosis of a metastatic malignancy lead to the subsequent detection of the primary malignancy. These included one case each of melanoma, myeloma, rhabdomyosarcoma, and small-cell carcinoma of the lung. There were five pediatric cases that included four cases of rhabdomyosarcoma and one case of leukemic deposit. The adult cases included two cases each of melanoma, small-cell carcinoma, and myeloma; one case of choriocarcinoma; and three cases of soft-tissue sarcomas. These included two cases of malignant fibrous histiocytoma (MFH) and one case of leiomyosarcoma. The presence of unusual cytomorphological patterns on breast FNA should alert the cytopathologist to the possibility of a metastatic breast neoplasm, even if not suspected clinically. A detailed history of the patient, clinical correlation, and immunocytochemistry helps in establishing an accurate diagnosis, which avoids unnecessary surgery and ensures appropriate treatment.

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Fine-needle aspiration biopsy of a case of breast carcinoma with choriocarcinomatous features

2006

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Breast disease is of great concern to patients and health care providers alike. Malignancies of the breast and their various presentations can pose tremendous challenges with respect to early diagnosis and effective treatment. Carcinoma of the breast may appear in several forms and produce one or more ectopic substances. Breast carcinomas that display choriocarcinomatous differentiation and produce human chorionic gonadotropin are very rare. Less than a dozen such cases have been described in the medical literature to date. We report a case of breast carcinoma with choriocarcinomatous features, which is the first to show immunohistochemical evidence of the expression of both estrogen receptor and progesterone receptor. We also discuss the cytopathologic aspects observed and conduct a literature review.

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Breast Carcinomas With Choriocarcinomatous Features: Case Reports and Review of the Literature

Cited by 31 publications

References 8 publications

Carcinoma of the Breast With Choriocarcinomatous Features

Carcinoma of the Breast With Choriocarcinomatous Features

Fine-needle aspiration cytology of extramammary neoplasms metastatic to the breast

Fine-needle aspiration biopsy of a case of breast carcinoma with choriocarcinomatous features

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