Breast carcinoma: periodicity in presentation of metastatic tumour growth in the axilla

Hartveit, F

doi:10.1007/bf00058172

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…16 Furthermore, it was found that the metastatic behavior of breast cancer can follow specific patterns, with periods of inactivity in which new tumor colonies in the axilla are not being seasonal variability of carcinomatous meningitis recruited. 8 It was also shown that the rate of micrometastases in the axillary lymph nodes was higher during the second half of the year. 9 Additionally, Mason et al demonstrated that the season the initial tumor was diagnosed was highly associated with the prognosis in breast cancer models.…”

Section: Discussionmentioning

confidence: 96%

Seasonal variability in the incidence of carcinomatous meningitis

Koutras¹,

Sakellakis²,

Makatsoris³

et al. 2015

JNS

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OBJECT The aim of the study was to investigate whether there are seasonal differences in the occurrence of carcinomatous meningitis (CM), with a greater prevalence of the disease in months with higher temperatures. METHODS The authors searched the records of all patients with a diagnosis of CM from 1998 until 2013 at the University Hospital of Patras, Greece. The date of hospitalization was extracted for each patient. The cases were divided into 2 categories depending on the time of CM diagnosis. Based on the official data regarding the annual temperature distribution in this region, the authors divided the patients into 2 groups. The first group consisted of cases diagnosed with CM from October 15 to April 15 (cold climate and shorter daytime duration), whereas the second group comprised patients diagnosed between April 15 and October 15 (warm climate and longer daytime duration). RESULTS Overall, 44 confirmed cases of CM were found. The most common type of malignancy associated with the development of CM was breast cancer (27 patients), while the second most common tumor was lung carcinoma (11 patients). The median interval between the time of initial cancer diagnosis and CM was 4.5 years. Thirty-one patients were diagnosed with CM during the period between April 15 and October 15, while the remaining 13 patients developed CM between October 15 and April 15, a significant difference (p = 0.01). CONCLUSIONS Significantly more patients developed CM during the warm season of the year. To the authors' knowledge, this is the first study to provide evidence for the potential seasonal variability in CM incidence. However, these results should be validated prospectively in larger cohorts.

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Section: Discussionmentioning

confidence: 96%

Seasonal variability in the incidence of carcinomatous meningitis

Koutras¹,

Sakellakis²,

Makatsoris³

et al. 2015

JNS

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“…For thyroid tumour diameter, there was a maximum period in the last months of the year between September and January, with a peak on December 8. In breast cancer, studies have shown that these tumours were also largest in the autumn (Hartveit et al, 1983;Hartveit, 1992). For thyroid tumour cell proliferation, maximal tumour growth was found in autumn and winter for both S-phase and G2M-phase fractions, and cosinor analysis indicated that the acrophases were located on September 28 for S-phase and November 3 for G2M-phase.…”

Section: Hospital Casesmentioning

confidence: 98%

Seasonal variations in the presentation and growth of thyroid cancer

Akslen

Rb²

1998

Br J Cancer

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Summary Seasonal variation has been described in the presentation and growth of several malignant tumours, including cancers of the breast, uterus, uterine cervix, urinary bladder, liver, lymphatic system and skin, although the mechanisms are not known. We herein describe a circannual rhythm for thyroid cancer (total = 2627), with significantly more cases presenting during the late autumn and winter. In a subset of these cases (127 papillary carcinomas), significant seasonal variations with highest values in autumn-winter were found for tumour diameter and proliferation indicators (S-and G2M-phase fractions). These results indicate the likelihood of a seasonal factor (or factors) of importance for the regulation and modification of tumour cell proliferation. When further clarified, this might be of relevance for the planning of diagnostic and therapeutic strategies.Keywords: thyroid cancer; season; tumour diameter; proliferation; %S-phase-%G2M-phase Biological rhythms, especially circadian (24 h) and circannual (12 months), have been found in a wide range of physiological parameters and normal tissues (Aschoff, 1981; Shifrine et al, 1982;Halberg et al, 1983;Lerum et al, 1988;Sothem et al, 1995). Regarding seasonal variations, higher incidence of female breast cancer has been reported for the spring and summer (Cohen et al, 1983;Mason et al, 1985), and circannual contrasts have also been found for other tumours (Newell et al, 1985;Swerdlow, 1985; Hermida and Ayala, 1996). As for the thyroid, some studies have reported seasonal variations in endocrine parameters, with variables such as T3, T4 and thyroid-stimulating hormone (TSH) being higher in the autumn or winter (Halberg et al, 1981;Nicolau et al, 1987;Haus et al, 1988). As seasonal variations might be of potential interest for the detection and management of thyroid carcinomas, we wanted to review this group of tumours, most of which are slowly growing and have a good prognosis. MATERIALS AND METHODS PatientsDuring the period 1970-85, 2627 patients with thyroid cancer were reported to the Cancer Registry of Norway. Of these, 10% (n = 263) were surgically treated at the Department of Surgery, Haukeland University Hospital, in the period 1971-85. There were no major differences in the distribution of sex, age and histological types between our hospital cases and cases in the population-based Cancer Registry (Akslen and Myking, 1992 subtyping of malignant tumours according to the 1988 WHO criteria, 127 of these cases were found to represent papillary thyroid carcinomas with a diameter greater than 10 mm (microcarcinomas < 10 mm were excluded). These 127 cases were included for further studies of seasonal variations with reference to time (month) of diagnosis, largest diameter of the primary tumour and proliferation indicators (S-phase and G2M-phase fractions). Most of these patients (93%) were treated with total or near-total thyroidectomy. Regarding time of diagnosis, the date of initial histological/cytological diagnosis was used for both the registry (n = 26...

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“…The axilla provides a nodal 'site' in which tumour growth may be calibrated in different ways, allowing study of its progression in them. The presence of a yearly growth cycle in primary breast carcinoma has been reported from different parts of the world, including Norway [4][5][6][7][8][9][10][11], where it has also been related to nodal growth [12][13][14]. The present study concerns the numbers of cases presenting with different histological stages of nodal growth from breast carcinoma and the relation this bears to the yearly growth cycle of this metastatic tumour.…”

Section: Introductionmentioning

confidence: 99%

Nodal Tumour Growth in Breast Cancer: The Time-Span of Its Biological Progression

Hartveit

1998

Tumor Biol

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This series of 1,154 women with unilateral breast carcinoma was treated by modified radical mastectomy with axillary dissection. Histological staging of nodal tumour growth in the axilla distinguished 4 populations in which the numbers of patients presenting for operation over the months of the year differed markedly. The findings are used to develop a hypothesis on nodal tumour growth in which the length of time needed to complete the growth sequence, from the entry of a micrometastasis to exit of tumour cells via the efferent nodal vessels, could be estimated. The results suggest that the time-span may be as much as 3 years, and probably more.

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Breast carcinoma: periodicity in presentation of metastatic tumour growth in the axilla

Cited by 4 publications

References 16 publications

Seasonal variability in the incidence of carcinomatous meningitis

Seasonal variability in the incidence of carcinomatous meningitis

Seasonal variations in the presentation and growth of thyroid cancer

Nodal Tumour Growth in Breast Cancer: The Time-Span of Its Biological Progression

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