Breast cancers with extremely high oestrogen receptor protein status

Abstract

Seventeen cases of primary and one case of metastatic breast cancer which expressed greater than 900 fmol oestrogen receptor sites per mg soluble protein were examined. All these patients were post-menopausal at the time of their presentation. These were a heterogeneous group of well-differentiated cellular breast carcinomas, comprising cases of invasive duct carcinoma with extensive tubular differentiation or with focal argyrophilia, tubulolobular carcinoma, lobular carcinoma of mixed type containing abundant intracytoplasmic lumina, papillary carcinoma and type B colloid carcinoma. There was very little tumour necrosis. Nodal Keywords: cancer, breast, histology, oestrogen receptors metastasis, tumour size and host inflammatory response did not appear to show any relationship with oestrogen receptor status. The patients, apart from two who died from other causes, remain alive (Fisher's exact test, P<O.01). In contrast, 17 randomly selected cases of oestrogen receptor negative breast cancer in the same study period were focally necrotic, poorly-differentiated invasive duct carcinomas. Six patients died from metastatic disease, seven were alive and well, one was alive with metastatic disease, one was lost to follow-up and two died from diseases unrelated to breast cancer.

Status of HER-2/neu receptors and Ki-67 in breast cancer of Indian women

“…[1] Presence of both ER and progesterone receptor (PgR) is related to better prognosis and responsiveness to hormonal therapy. [2] Proper understanding of prognostic features of breast cancer can help in the selection of appropriate treatment for the individual patient. These features are lymph node involvement, tumor size and grade, status of ER and PgR, status of the cancer biomarker HER-2/neu gene expression profile, and patient's age.…”