Breast cancer tumor size: correlation between magnetic resonance imaging and pathology measurements

Onesti, Jill K.; Mangus, Barry E.; Helmer, Stephen D.; Osland, Jacqueline S.

doi:10.1016/j.amjsurg.2008.07.028

Cited by 102 publications

(97 citation statements)

References 19 publications

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“…Limits within which measurements on MRI are considered concordant with measurements at pathology vary and range from 0 mm -20 mm [11,[24][25][26][27]. We used a limit of 10 mm to define concordance and Bland Altman plots to measure systematic and random differences.…”

Section: Discussionmentioning

confidence: 99%

Which factors influence MRI-pathology concordance of tumour size measurements in breast cancer?

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Which factors influence MRI-pathology concordance of tumour size measurements in breast cancer?

et al. 2015

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“…A review of the correlation between MRI-determined tumor size and pathologically determined tumor size is imperative. MRI tumor size correlates with pathologically determined size; however, significant overestimation occurs in cases where both invasive and non-invasive tumors are present (42). In our study, tumor staging on final pathology was associated with re-excision (p = 0.045).…”

Section: Discussionmentioning

confidence: 52%

Magnetic Resonance Imaging Factors Predicting Re-excision in Breast Cancer Patients Having Undergone Conserving Therapy

Jang

Kim

Yun

et al. 2014

J Korean Soc Magn Reson Med

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“…This finding is consistent with prior studies (Table 1). 1,3,6,[12][13][14][15][16][17][18][19][20][21] Tumour size measured by micro-CT correlated better with histopathological invasive tumour size than any of the three pre-operative imaging modalities. This is likely because micro-CT generates higher resolution images, making fine structures, anatomic features and tumour boundaries more clearly visible.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative micro-computed tomography (micro-CT): a novel method for determination of primary tumour dimensions in breast cancer specimens

Tang

Saksena

Coopey

et al. 2016

BJR

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Objectives: Micro-CT is a promising modality to determine breast tumour size in three dimensions in intact lumpectomy specimens. We compared the accuracy of tumour size measurements using specimen micro-CT with measurements using multimodality pre-operative imaging. Methods: A tabletop micro-CT was used to image breast lumpectomy specimens. The largest tumour dimension on three-dimensional reconstructed micro-CT images of the specimen was compared with the measurements determined by pre-operative mammography, ultrasound and MRI. The largest dimension of pathologic invasive cancer size was used as the gold standard reference to assess the accuracy of imaging assessments. Results: 50 invasive breast cancer specimens in 50 patients had micro-CT imaging. 42 were invasive ductal carcinoma, 6 were invasive lobular carcinoma and 2 were other invasive cancer. Median patient age was 63 years (range 33-82 years). When compared with the largest pathologic tumour dimension, micro-CT measurements had the best correlation coefficient (r 5 0.82, p , 0.001) followed by MRI (r 5 0.78, p , 0.001), ultrasound (r 5 0.61, p , 0.001) and mammography (r 5 0.40, p , 0.01). When compared with preoperative modalities, micro-CT had the best correlation coefficient (r 5 0.86, p , 0.001) with MRI, followed by ultrasound (r 5 0.60, p , 0.001) and mammography (r 5 0.54, p , 0.001). Overall, mammography and ultrasound tended to underestimate the largest tumour dimension, while MRI and micro-CT overestimated the largest tumour dimension more frequently. Conclusion: Micro-CT is a potentially useful tool for accurate assessment of tumour dimensions within a lumpectomy specimen. Future studies need to be carried out to see if this technology could have a role in margin assessment. Advances in knowledge: Micro-CT is a promising new technique which could potentially be used for rapid assessment of breast cancer dimensions in an intact lumpectomy specimen in order to guide surgical excision.

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Breast cancer tumor size: correlation between magnetic resonance imaging and pathology measurements

Cited by 102 publications

References 19 publications

Which factors influence MRI-pathology concordance of tumour size measurements in breast cancer?

Which factors influence MRI-pathology concordance of tumour size measurements in breast cancer?

Magnetic Resonance Imaging Factors Predicting Re-excision in Breast Cancer Patients Having Undergone Conserving Therapy

Intraoperative micro-computed tomography (micro-CT): a novel method for determination of primary tumour dimensions in breast cancer specimens

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