Breast Cancer Survival among South Asian Women in California (United States)

Parikh‐Patel, Arti; Mills, Paul K.; Jain, Ratnali

doi:10.1007/s10552-005-0520-2

Cited by 18 publications

(18 citation statements)

References 22 publications

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“…South Asians, whose land of origin is the Indian subcontinent (28, 22), are comprised of Asian Indian, Pakistani, other South Asian, Bangladeshi, Bhutanese, Nepalese, Sikh, and Sri Lankan. Excluded from our analyses were 302 HCC cases from smaller Asian groups or with unspecified ethnicity.…”

Section: Methodsmentioning

confidence: 99%

“…There are currently more than five million Asian Americans in California who constitute more than 14 percent of the state’s population (20–21). In order to monitor the incidence rates, risk factors, treatments and survival from cancer among the different ethnicities that make up this varied group, we used data from the California Cancer Registry (CCR) which comprises the world’s largest repository of high quality ethnically-specific cancer data for Asian Americans in a geographically contiguous jurisdiction (22). Most recently, ethnically-specific HCC survival data from the California Cancer Registry for the 20-year period, 1988–2007 have become available.…”

Section: Introductionmentioning

confidence: 99%

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Disparities in Hepatocellular Carcinoma Survival among Californians of Asian Ancestry, 1988 to 2007

Kwong

Stewart

Aoki

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Hepatocellular carcinoma (HCC) represents a significant health disparity affecting Asian Americans, a population comprised of distinct ethnic groups. The purpose of this article is to analyze Californians of Asian ancestry with HCC with respect to socioeconomic status, demographic factors, stage of disease, treatment received, and survival.Methods: To investigate ethnic differences in survival, we analyzed ethnically disaggregated data from 6,068 Californians of Asian ancestry with HCC diagnosed in 1988 to 2007 and reported to the California Cancer Registry.Results: Compared with the average of all ethnic groups, cause-specific mortality was significantly higher among Laotian/Hmong [hazard ratio, 2.08; 95% confidence interval (95% CI), 1.78-2.44] and Cambodian patients (hazard ratio, 1.26; 95% CI, 1.06-1.51), groups with higher proportions of their populations at low levels of socioeconomic status; in addition, Laotian/Hmong patients disproportionately presented at later stages of disease, with only 3% receiving local surgical treatment, resection, or liver transplantation. After adjustment for time of diagnosis, age at diagnosis, gender, geographic region, stage at diagnosis, type of surgery, and socioeconomic status, survival disparities remained for both groups (Laotian/Hmong hazard ratio, 1.51; 95% CI, 1.28-1.79; Cambodian hazard ratio, 1.24; 95% CI, 1.03-1.48).Conclusions: Our hypothesis that survival outcomes would differ by ethnicity was verified. Impact: Research is needed not only to develop more effective treatments for HCC but also to develop community-based interventions to recruit Asian Americans, particularly Laotian/Hmong and Cambodians, for hepatitis B screening and into medical management to prevent or detect this tumor at an early stage.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Disparities in Hepatocellular Carcinoma Survival among Californians of Asian Ancestry, 1988 to 2007

Kwong

Stewart

Aoki

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Accumulating evidence suggests that the molecular profile of breast cancer differs between ethnic groups, which, in turn, can influence their behaviour and response to therapy [1, 2]. Modern molecular pathology techniques have revealed 4 core taxonomic groups of breast cancer; luminal A, luminal B, basal, and HER2+, which can now be assessed using immunohistochemistry as a surrogate [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Differential Expression of MicroRNAs in Breast Cancers from Four Different Ethnicities

et al. 2018

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Introduction: Breast cancer outcomes vary across different ethnic groups. MicroRNAs (miRs) are small non-coding RNA molecules that regulate gene expression across a range of pathologies, including breast cancer. The aim of this study was to evaluate the presence and expression of miRs in breast cancer samples from different ethnic groups. Materials and Methods: Breast cancer tissue from 4 ethnic groups, i.e., British Caucasian, British Black, Nigerian, and Indian, were identified and matched for patients’ age, tumour grade/type, and 10 × 10 µm sections taken. Tumour areas were macrodissected, total RNA was extracted, and cDNA was synthesised. cDNA was applied to human miScript PCR arrays allowing the quantification of 84 of the most abundantly expressed/best-characterised miRs. Results: Differential expression of 9 miRs was seen across the 4 groups. Significantly higher levels of miR-140-5p, miR-194 and miR-423-5p (the last of which harbours the single-nucleotide polymorphism rs6505162) were seen in the breast tumours of Nigerian patients when compared with other ethnic groups (all p < 0.0001). miR-101 was overexpressed in breast cancers in the Indian patients. An in silico analysis of miR-423-5p showed that the AC genotype is mainly associated with Europeans (57%), while Asians display mostly CC (approx. 60%), and Africans mainly AA (approx. 60%). Conclusions: This study shows divergence in miR expression in breast cancers from different ethnic groups, and suggests that specific genetic variants in miR genes may affect breast cancer risk in these groups. Predicted targets of these miRs may uncover useful biomarkers that could have clinical value in breast cancers in different ethnic groups.

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“…Asian Indian is a term used by the US Census Bureau to describe Americans who trace their heritage to India and to distinguish people from India from American Indians or Native Americans. Among Asian Indian women, breast cancer is the leading cancer in both incidence and mortality [5], and Asian Indian women living in the US have a higher breast cancer incidence than Asian Indian women in India [10, 11]. …”

Section: Introductionmentioning

confidence: 99%

“…Breast cancer screening is a means to detect breast cancer early and reduce related mortality [11]. The American Medical Association (AMA), the American Cancer Society (ACS), the American College of Obstetricians and Gynecologists (ACOG) and the US Preventive Services Task Force (USPSTF) recommend mammography for women aged 40 plus annually or biennially [12–14], and all but the USPSTF recommend clinical breast exams (CBE) no less than once every 2 years for women 40 and over [14].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Breast Cancer Screening in Asian Indian Women in Metro-Detroit

Boxwala

Bridgemohan

Griffith

et al. 2009

J Immigrant Minority Health

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Few studies have examined social factors related to breast cancer screening in Asian Indian women in the Midwestern US. This cross-sectional, community-based survey utilized constructs of the Health Belief Model to examine factors associated with breast cancer screening among Asian Indian women in metropolitan Detroit, Michigan. Of the 160 participants, 63.8% reported receiving both a clinical breast exam and mammogram within the past 2 years. Women were more likely to screen for breast cancer if they had a college education, lived in the US for more years, perceived that breast cancer screening is useful in detecting breast cancer early, agreed that mammography was important, and received a recommendation by a healthcare provider to get a mammogram. These findings highlight the need for further research on regional differences in breast cancer screening knowledge, behaviors and predictors among Asian Pacific Islanders subgroups such as Asian Indian women who recently immigrated to the US.

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Breast Cancer Survival among South Asian Women in California (United States)

Abstract: These data suggest the need for targeted efforts to improve early stage diagnosis among South Asian women. Further research into the factors that influence survival among South Asians is also needed.

Cited by 18 publications

References 22 publications

Disparities in Hepatocellular Carcinoma Survival among Californians of Asian Ancestry, 1988 to 2007

Disparities in Hepatocellular Carcinoma Survival among Californians of Asian Ancestry, 1988 to 2007

Differential Expression of MicroRNAs in Breast Cancers from Four Different Ethnicities

Factors Associated with Breast Cancer Screening in Asian Indian Women in Metro-Detroit

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