Breast cancer, screening and diagnostic tools: All you need to know

Barba, Diego; León-Sosa, Ariana; Lugo, Paulina; Suquillo, D.; Torres, Fernando; Surre, F.; Trojman, Lionel; Caicedo, Andrés

doi:10.1016/j.critrevonc.2020.103174

Cited by 69 publications

(49 citation statements)

References 392 publications

(615 reference statements)

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“…Once using an imaging technique an anomaly is found in the breast tissue, for diagnoses, prognosis and treatment purposes, cytological, histological and molecular analysis is applied to biopsies using genetic tests [gene sequencing and gene expression profiling signature (GEP/S) (28)(29)(30)] and biochemical markers (31)(32)(33)(34)(35). Biochemical markers can be found in tissues (31) and within the circulating blood (36) [e.g., circulating tumor cells (CTCs)]. Established biochemical biomarkers are proteins and comprise of ki6 7 (37), ER [ERa (38) and ERb (39)], PR (33) and HER2 (40).…”

Section: Introductionmentioning

confidence: 99%

B4GALNT2 Gene Promotes Proliferation, and Invasiveness and Migration Abilities of Model Triple Negative Breast Cancer (TNBC) Cells by Interacting With HLA-B Protein

et al. 2021

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B4GALNT2 gene encodes the enzyme β1,4-N-acetylgalactosaminyltransferase 2 that biosynthesizes the histo-blood group antigen Sda, which is expressed on the surface of erythrocytes and in body secretions. Analysis of The Cancer Genome Atlas (TCGA) database revealed that this gene was highly expressed in breast cancer tissues in comparison with adjacent healthy ones. In-vitro lentivirus-assisted B4GALNT2 gene knockdown experiments in model triple negative breast cancer (TNBC) cell lines (HCC1937 and MDA-MB-231) showed inhibition in cell proliferation, decrease in cell viability, promotion of cell apoptosis and inhibitions in cell migration and invasiveness abilities in comparison with empty lentivirus transfectant controls. Also, in cell cycle tests, the number of cells in the G1 phase increased, in the S phase decreased and did not change in the G2/M phase (indicative of the presence of a block in the G1 phase). In-vivo tumor formation experiments in mice revealed that knockdown of the B4GALNT2 gene in MDA-MB-231 cells inhibited their proliferation. Using co-immunoprecipitation (Co-IP) mass spectroscopy-assisted analysis, it was found that HLA-B protein [a product of the human leukocyte antigen (HLA) class I gene] interacts with B4GALNT2 protein. In-vitro overexpression of HLA-B in B4GALNT2-knocked down MDA-MB-231 cell lines significantly recovered the cell proliferation, viability and migration ability of B4GALNT2 gene. These indicate that HLA-B is one of the interaction proteins in the downstream pathway of the B4GALNT2 gene.

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Section: Introductionmentioning

confidence: 99%

B4GALNT2 Gene Promotes Proliferation, and Invasiveness and Migration Abilities of Model Triple Negative Breast Cancer (TNBC) Cells by Interacting With HLA-B Protein

et al. 2021

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“…Further interdisciplinary studies in vivo or in patients will support the in silico role of the identified and overlapped proteins. Interdisciplinarity is important as it brings together specialists in bioinformatics, health care professionals and technical experts leading to the development of better screening methods for early diagnosis and therapies 106 . These studies would allow therapeutic targeting and the development of specific pharmacological compounds that would stop cancer progression without affecting the healing process.…”

Section: Discussionmentioning

confidence: 99%

Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes

López‐Cortés

Abarca

Silva

et al. 2021

Sci Rep

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Wound healing (WH) and cancer seem to share common cellular and molecular processes that could work in a tight balance to maintain tissue homeostasis or, when unregulated, drive tumor progression. The “Cancer Hallmarks” comprise crucial biological properties that mediate the advancement of the disease and affect patient prognosis. These hallmarks have been proposed to overlap with essential features of the WH process. However, common hallmarks and proteins actively participating in both processes have yet to be described. In this work we identify 21 WH proteins strongly linked with solid tumors by integrated TCGA Pan-Cancer and multi-omics analyses. These proteins were associated with eight of the ten described cancer hallmarks, especially avoiding immune destruction. These results show that WH and cancer's common proteins are involved in the microenvironment modification of solid tissues and immune system regulation. This set of proteins, between WH and cancer, could represent key targets for developing therapies.

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“…43 Screening programs for cancers like breast, cervix, and colorectum are established. [44][45][46] There are many established criteria for cancer screening. 9 The initial criteria were subsequently modified to bring in the more rigorous standards of evidence required to prove effectiveness, and the apprehensions about overdiagnosis resulting from false positive tests or lead time bias.…”

Section: Sensitivity Analysismentioning

confidence: 99%

Cost‐effectiveness of oral cancer screening approaches by visual examination: Systematic review

et al. 2021

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The present study is the first systematic review of papers that have performed a full economic evaluation on oral cancer screening strategies using visual oral examination. The review questions were (1) Is screening a cost-effective strategy in oral cancer? (2) What is the most cost-effective strategy among the different screening approaches in oral cancer? The main outcome measure was the incremental cost-effectiveness ratio. The study identifies and reviews seven full economic evaluations. The included studies scored 75%-100% on the methodological appraisal. Majority of the studies reports that oral cancer screening is a cost-effective strategy, especially in an opportunistic setting and high-risk subset of patients. The results were sensitive to cost and effectiveness parameters. Oral cancer screening, though found cost-effective, the uncertainty around these parameters necessitates additional studies that include better estimates in the modeling assessments. The heterogeneity in studies limited comparison and generalization.

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Breast cancer, screening and diagnostic tools: All you need to know

Cited by 69 publications

References 392 publications

B4GALNT2 Gene Promotes Proliferation, and Invasiveness and Migration Abilities of Model Triple Negative Breast Cancer (TNBC) Cells by Interacting With HLA-B Protein

B4GALNT2 Gene Promotes Proliferation, and Invasiveness and Migration Abilities of Model Triple Negative Breast Cancer (TNBC) Cells by Interacting With HLA-B Protein

Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes

Cost‐effectiveness of oral cancer screening approaches by visual examination: Systematic review

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