Breast Cancer Screening

Pisano, Etta D.; Yaffe, Martin J.

doi:10.1001/jama.2014.6421

Cited by 20 publications

(4 citation statements)

References 17 publications

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“…Sample images of breast and lesions are presented in Figure 2. The lesion characteristics were adjusted during several prepilot stages to achieve a DM performance comparable to reported values …”

Section: Methodsmentioning

confidence: 99%

“…The evaluation of novel imaging technologies for screening typically requires a substantial clinical trial to demonstrate benefits compared with the standard of care. 1 For example, regulatory approvals of digital breast tomosynthesis (DBT) are supported by clinical trials involving significant resources. A recent submission to the US Food and Drug Administration (FDA) of a DBT system as a replacement for digital mammography (DM), for example, 2 relied on a clinical trial involving 400 women in 7 clinical sites receiving double exposure to ionizing radiation over many years, with 31 participating radiologists.…”

Section: Introductionmentioning

confidence: 99%

“…Expensive and lengthy clinical trials for imaging products often hinder regulatory evaluation, are burdensome, and delay patient access to novel, high-quality devices. The evaluation of novel imaging technologies for screening typically requires a substantial clinical trial to demonstrate benefits compared with the standard of care . For example, regulatory approvals of digital breast tomosynthesis (DBT) are supported by clinical trials involving significant resources.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Digital Breast Tomosynthesis as Replacement of Full-Field Digital Mammography Using an In Silico Imaging Trial

et al. 2018

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Key Points Question Can in silico imaging trials play a role in the evaluation of new medical imaging systems? Findings This diagnostic study used computer-simulated imaging of 2986 synthetic image–based virtual patients to compare digital mammography and digital breast tomosynthesis and found an improved lesion detection performance favoring tomosynthesis for all breast sizes and lesion types. The increased performance for tomosynthesis was consistent with results from a comparative trial using human patients and radiologists. Meaning The study’s findings suggest that in silico imaging trials and imaging system computer simulation tools can in some cases be considered viable sources of evidence for the regulatory evaluation of imaging devices.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Digital Breast Tomosynthesis as Replacement of Full-Field Digital Mammography Using an In Silico Imaging Trial

et al. 2018

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“…Concerns about harm from false positive and false negative diagnoses [2] create a considerable incentive for development of improved mammographic techniques. Improving sensitivity and specificity of existing breast cancer imaging technologies, could improve detection [3]; doing this while delivering reduced Xray dose to the patient, and, preferably, also removing or reducing the considerable physical discomfort experienced by many patients during the conventional breast screening procedures [4][5][6][7][8][9] would be an added benefit. Propagation-based phase-contrast X-ray CT (PB-CT), which exploits refraction (in addition to absorption) of X-rays in tissue, shows particular promise in this regard due to its superior sensitivity to soft-tissue tumors [5][6][7][8][9][10][11][12][13][14][15][16][17].…”

mentioning

confidence: 99%

Synchrotron-Based X-ray Phase-Contrast Tomography for Breast Cancer Imaging

Gureyev¹,

Baran

Pacilè

et al. 2018

Microsc Microanal

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Propagation‐based x‐ray phase‐contrast tomography of mastectomy samples using synchrotron radiation

et al. 2019

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Purpose Propagation‐based phase‐contrast computed tomography (PB‐CT) is a method for three‐dimensional x‐ray imaging that utilizes refraction, as well as absorption, of x rays in the tissues to increase the signal‐to‐noise ratio (SNR) in the resultant images, in comparison with equivalent conventional absorption‐only x‐ray tomography (CT). Importantly, the higher SNR is achieved without sacrificing spatial resolution or increasing the radiation dose delivered to the imaged tissues. The present work has been carried out in the context of the current development of a breast CT imaging facility at the Australian Synchrotron. Methods Seven unfixed complete mastectomy samples with and without breast cancer lesions have been imaged using absorption‐only CT and PB‐CT techniques under controlled experimental conditions. The radiation doses delivered to the mastectomy samples during the scans were comparable to those approved for mammographic screening. Physical characteristics of the reconstructed images, such as spatial resolution and SNR, have been measured and compared with the results of the radiological quality assessment of the complete absorption CT and PB‐CT image stacks. Results Despite the presence of some image artefacts, the PB‐CT images have outperformed comparable absorption CT images collected at the same radiation dose, in terms of both the measured objective image characteristics and the radiological image scores. The outcomes of these experiments are shown to be consistent with predictions of the theory of PB‐CT imaging and previous reported experimental studies of this imaging modality. Conclusions The results presented in this paper demonstrate that PB‐CT holds a high potential for improving on the quality and diagnostic value of images obtained using existing medical x‐ray technologies, such as mammography and digital breast tomosynthesis (DBT). If implemented at suitable synchrotron imaging facilities, PB‐CT can be used to complement existing imaging modalities, leading to more accurate breast cancer diagnosis.

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Breast Cancer Screening

Cited by 20 publications

References 17 publications

Evaluation of Digital Breast Tomosynthesis as Replacement of Full-Field Digital Mammography Using an In Silico Imaging Trial

Evaluation of Digital Breast Tomosynthesis as Replacement of Full-Field Digital Mammography Using an In Silico Imaging Trial

Synchrotron-Based X-ray Phase-Contrast Tomography for Breast Cancer Imaging

Propagation‐based x‐ray phase‐contrast tomography of mastectomy samples using synchrotron radiation

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