Breast Cancer Risk Factors in Women Participating in a Breast Screening Program: a Study on 11,850 Iranian Females

Sepandi, Mojtaba; Akrami, Majid; Tabatabaee, Hamidreza; Rajaeefard, Abdolreza; Tahmasebi, Sedigheh; Angali, Kambiz Ahmadi; Rezaianzadeh, Abbas; Talei, Abdolrasoul

doi:10.7314/apjcp.2014.15.19.8499

Cited by 32 publications

(26 citation statements)

References 29 publications

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“…Further, 19.09% had low BMI (less than 18.5) indicating underweight. Similar findings were also observed by Sepandi M et al [20] and Meshram II et al [19] in different studies [19,20].…”

Section: Discussionsupporting

confidence: 80%

The Relevance of Established Risk Factors in Context to Indian Breast Cancer Patients

Chauhan

2016

MOJWH

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Breast cancer is the most common cancer affecting the females across the world and even in India. There has been an alarming rise in the incidence of breast cancer and there is an urgent need to control them by modifying the risk factors. Various risk factors with convincing evidence of causing breast cancer have been identified. These include increasing age, young age at first child birth, null parity, obesity, avoiding breast feeding, use of oral contraceptives and alcohol. However, the physique and the lifestyle of Indian breast cancer patients are quite different from their western counterparts. Various epidemiological studies from India do not show the presence of these risk factors in a convincing form. So, this review was done to evaluate the prevalence of risk factors in Indian breast cancer patients.

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“…Further, 19.09% had low BMI (less than 18.5) indicating underweight. Similar findings were also observed by Sepandi M et al [20] and Meshram II et al [19] in different studies [19,20].…”

Section: Discussionsupporting

confidence: 80%

The Relevance of Established Risk Factors in Context to Indian Breast Cancer Patients

Chauhan

2016

MOJWH

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“…In 18 articles, the data of age at menarche were reported in terms of age groups (qualitatively) (18,(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). Three articles had similar data (24)(25)(26) and therefore only one of them was included in the analysis.…”

Section: Description Of the Studiesmentioning

confidence: 99%

Role of Menopause and Early Menarche in Breast Cancer: A Meta-Analysis of Iranian Studies

Zahmatkesh¹,

Keramat²,

Alavi³

et al. 2016

Nurs Midwifery Stud

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Context: Various studies in Iran on the role of menopause and age at menarche in breast cancer reported different results. Objectives: The current study aimed to estimate the overall odds ratio and explore the association between early menarche and menopause with breast cancer. Data Sources: Scopus, Web of Science, PubMed, Google Scholar and Iranian databases such as Magiran and SID, breast cancer key journals (Asian pacific journal of cancer prevention, Iranian quarterly journal of breast) and conferences (international breast cancer congresses in Iran, annual breast cancer conferences and seminars in Iran) were searched from 2004 to 2014. Study Selection: The observational studies in Iran that had reported the relationship between menopause and early menarche with breast cancer were searched. The exposure was menopause and early menarche and the outcome was breast cancer with pathological confirmation. Data Extraction: Using strengthening the reporting of observational studies in epidemiology (STROBE) checklist, quality assessment of the articles and data extraction were performed separately by two authors. Results: Of 4396 articles, 12 studies with a sample size of 27734, 11 studies with a sample size of 4039 and 20 studies with a sample size of 53417 were analyzed to estimate the overall odds ratio (OR) for early menarche and the standardized mean difference (SMD) of the average menarche age and overall OR of menopause, respectively. A significant relationship was observed between early menarche and breast cancer (OR = 1.57, 95% confidence interval (CI) = 1.05, 2.34). The mean menarche age in patients was also significantly lower than in healthy females (SMD =-0.087, 95%CI =-0.151,-0.02). Postmenopausal female had a higher risk for developing breast cancer; however, this relationship was not statistically significant (OR=1.35, 95%CI=0.98, 1.86). Conclusions: Menopause and early menarche increase the odds of breast cancer. Therefore, breast cancer prevention and screening programs are needed to reduce the burden of this cancer and improve the quality of females' lives.

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“…Therefore, the results of the present study were heterogeneous and the difference among studies or Tau 2 = 0.18. From 7 analyzed studies, 3 studies showed no significant relation between obesity and breast cancer (8,17,18). Out of 7 analyzed studies, 5 studies reported no significant relation between overweightness and breast cancer in women (8,17,18,21,23).…”

Section: Effect Of Exposurementioning

confidence: 99%

“…In one article (8), overweightness was the protecting factor and 4 studies showed no significant relation between overweightness and breast cancer (17,18,21,23).…”

Section: Effect Of Exposurementioning

confidence: 99%

Body Mass Index and Risk of Breast Cancer: A Systematic Review and Meta-Analysis in Iran

et al. 2017

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Background: Various studies in Iran on the role of BMI higher than normal (BMI ≥25) on breast cancer have reported different results.Objective: The aim of this systematic review and meta-analysis is to estimate the odds ratio of overweightness and obesity as risk factors of breast cancer in studies conducted in Iran.Evidence Acquisition: The following main databases were searched from 2004 to 2014 to find related articles: PubMed, Web of Science, Google Scholar, Scopus and Iranian databases (SID and Magiran), breast cancer conferences held in Iran, key journals, and the references of the selected articles. Keywords were: Cancer, Tumor, Neoplasm, Neoplasia, Carcinoma, Malignancy, Malignant, Benign. The combination with OR and added it to search field with AND to words such as Iran and breast was used as the search strategy. The observational studies (cohort, case-control, and cross-sectional) in Iran that had reported the relation between BMI and breast cancer in Persian and English were searched. There were no limitations in terms of age, race, ethnicity, and marital status for women. The exposure was BMI ≥ 25 (overweight and obese) and the outcome was breast cancer with pathological confirmation.Two reviewers separately used the STROBE checklist for quality assessment, critically appraised papers and extract the data. The overall estimate was the odds ratio. Results:Of 4396 studies, after evaluation of heterogeneity, 7 case-control studies with a sample size of 33552 were included in the meta-analysis. A significant relation was observed between obesity (OR = 1.81, 95% CI = 1.24 -2.64) and odds of breast cancer. A significant relation was also observed between overweightness and odds of breast cancer (OR = 1.46, 95% CI = 1.13 -1.89).Conclusions: Meta-analysis results showed a significant relation between obesity and overweight with risk of breast cancer in Iranian women. We recommended Iranian women to be aware of the effect of weight on breast cancer and encouraged them to decrease their weight via physical activity and diet control.

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Breast Cancer Risk Factors in Women Participating in a Breast Screening Program: a Study on 11,850 Iranian Females

Cited by 32 publications

References 29 publications

The Relevance of Established Risk Factors in Context to Indian Breast Cancer Patients

The Relevance of Established Risk Factors in Context to Indian Breast Cancer Patients

Role of Menopause and Early Menarche in Breast Cancer: A Meta-Analysis of Iranian Studies

Body Mass Index and Risk of Breast Cancer: A Systematic Review and Meta-Analysis in Iran

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