Breast cancer risk factors and mammographic density among high-risk women in urban China

Sung, Hyuna; Ren, Jiansong; Li, Jing; Pfeiffer, Ruth M.; Wang, Yong; Guida, Jennifer; Fang, Yi; Shi, Jufang; Zhang, Kai; Li, Ni; Wang, Shen; Wei, Luopei; Hu, Nan; Gierach, Gretchen L.; Dai, Min; Yang, Xiaohong R.; He, Jie

doi:10.1038/s41523-018-0055-9

Cited by 57 publications

(69 citation statements)

References 72 publications

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“…This indicates the diagnostic advantage of DBT in premenopausal, postmenopausal, and dense breast populations. In Asian countries, including China, the female mammary gland is small and dense [ 39 ]. Compared to FFDM, DBT exhibits potential benefits in patients with dense breasts, such as reducing recall rates in screening mammography [ 6 ], improving preoperative cancer staging [ 12 ], improving cancer detection and mammographic sensitivity [ 17 ] by eliminating overlapping tissues, which can reduce false-positive rates and the number of biopsies.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Digital Breast Tomosynthesis for Breast Suspicious Calcifications From Various Populations: A Comparison With Full-field Digital Mammography

Zhang

Jiang

et al. 2019

Computational and Structural Biotechnology Journal

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The diagnostic performance difference between digital breast tomosynthesis (DBT) and conventional full-field digital mammography (FFDM) for breast suspicious calcifications from various populations is unclear. The objective of this study is to determine whether DBT exhibits the diagnostic advantage for breast suspicious calcifications from various populations compared with FFDM. Three hundred and five patients were enrolled (of which seven patients with bilateral lesions) and 312 breasts images were retrospectively analyzed by three radiologists independently. The postoperative pathology of breast calcifications was the gold standard. Breast cancer was diagnosed utilizing DBT and FFDM with sensitivities of 92.9% and 88.8%, specificities of 87.9% and 75.2%, positive predictive values of 77.8% and 62.1%, negative predictive values of 96.4% and 93.6%, respectively. DBT exhibited significantly higher diagnostic accuracy for benign calcifications compared with FFDM (87.9% vs 75.2%), and no advantage in the diagnosis of malignant calcifications. DBT diagnostic accuracy was notably higher than FFDM in premenopausal (88.4% vs 78.8%), postmenopausal (90.2% vs 77.2%), and dense breast cases (89.4% vs 81.9%). There was no significant difference in non-dense breast cases. In our study, DBT exhibited a superior advantage in dense breasts and benign calcifications cases compared to FFDM, while no advantage was observed in non-dense breasts or malignant calcifications cases. Thus, in the breast cancer screening for young women with dense breasts, DBT may be recommended for accurate diagnosis. Our findings may assist the clinicians in applying the optimal techniques for different patients and provide a theoretical basis for the update of breast cancer screening guideline.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Digital Breast Tomosynthesis for Breast Suspicious Calcifications From Various Populations: A Comparison With Full-field Digital Mammography

Zhang

Jiang

et al. 2019

Computational and Structural Biotechnology Journal

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“…14,21 Among postmenopausal women, we found that age at menopause of more than 55 years, compared with other age groups at menopause, had high breast density and increased odds of breast cancer, consistent with other studies based on Chinese women. 22,23 Menarche and menopause represent the start and end of ovarian and endocrine activity related to reproduction, respectively. 2 .51…”

Section: Discussionmentioning

confidence: 99%

Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women

et al. 2019

Cancer Medicine

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The incidence of breast cancer has increased dramatically in China. We evaluated the clinical and epidemiologic factors associated with breast cancer, and its stage in a case‐control study of Northeast Chinese women. We also examined whether these factors were differentially distributed among molecular subtypes of breast cancer in a case‐only analysis. We identified 1118 breast cancer patients and 2284 healthy women from Cancer Hospital of Medical University between January 2014 and December 2017. Logistic regression models were used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). We found that postmenopausal women had a decreased risk of breast cancer (multivariate‐adjusted OR = 0.33, 95% CI:0.25‐0.43), and tended to have breast cancer of human epidermal growth factor receptor 2 (HER2)‐overexpressing (multivariate‐adjusted OR = 2.99, 95% CI: 1.49‐5.97) and triple‐negative (multivariate‐adjusted OR = 2.16, 95% CI: 1.02‐4.56) subtypes, compared with the luminal B subtype. Women with history of abortion had an increased risk of breast cancer (multivariate‐adjusted OR = 4.70, 95% CI: 3.60‐6.14). Women with high breast density and high Breast Imaging Reporting and Data System (BIRADS) scores of lesions tended to have breast cancer of advanced stage, but were not differentially distributed among its molecular subtypes. In conclusion, postmenopausal women had decreased risk of breast cancer, and tended to have nonluminal subtype, while women with history of abortion had increased risk of breast cancer. Women with high breast density and BIRADS scores of lesions tended to have advanced stage breast cancer. We provide evidence on the epidemiologic factors for breast cancer and its subtypes, which may help with breast cancer risk stratification.

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“…Breast cancer (BC) is one of the most common malignant tumors among women in the world that seriously threaten women's health and quality of life (1)(2)(3). In recent years, with the development of economy and the change of lifestyle, the incidence of female BC in China has increased, and a trend for younger age at diagnosis has emerged (4)(5)(6). The occurrence of the majority of malignant tumors is associated with abnormal changes in certain key genes, such as inactivation of tumor suppressor genes, activation of oncogenes and abnormal expression of certain apoptosis-or proliferation-associated proteins (7,8).…”

Section: Introductionmentioning

confidence: 99%

miR‑200b regulates breast cancer cell proliferation and invasion by targeting radixin

Yuan¹,

Chu

Lu³

et al. 2020

Exp Ther Med

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Radixin is an important member of the Ezrin-Radixin-Moesin protein family that is involved in cell invasion, metastasis and movement. microRNA (miR)-200b is a well-studied microRNA associated with the development of multiple tumors. Previous bioinformatics analysis has demonstrated that miR-200b has a complementary binding site in the 3'-untranslated region of radixin mRNA. The present study aimed to investigate the role of miR-200b in regulating radixin expression, cell proliferation and invasion in breast cancer. Breast cancer tissues at different Tumor-Node-Metastasis (TNM) stages were collected; breast tissues from patients with hyperplasia were used as a control. miR-200b and radixin mRNA expression levels were tested by reverse transcription-quantitative PCR. Radixin protein expression was detected by western blotting. The highly metastatic MDA-MB-231 cells were divided into four groups and transfected with a miR-negative control (NC), miR-200b mimic, small interfering (si)RNA-NC or siRNA targeting radixin. Cell invasion was evaluated by Transwell assay and cell proliferation was assessed by 5-ethynyl-2'-deoxyuridine staining. Compared with the control group, radixin mRNA expression was significantly higher in breast cancer tissues and increased with TNM stage. miR-200b expression levels exhibited the opposite trend. Radixin mRNA expression in breast cancer cells was notably higher, whereas miR-200b expression was lower compared with that in normal breast epithelial MCF-10A cells. The expression of radixin was higher, whereas miR-200b was lower in MDA-MB-231 cells compared with that in MCF-7 cells. miR-200b mimic or siRNA-radixin transfection downregulated the expression of radixin in MDA-MB-231 cells and attenuated the invasive and proliferative abilities of these cells. miR-200b-knockdown and radixin overexpression were associated with enhanced cell invasion in breast cancer. In conclusion, miR-200b regulates breast cancer cell proliferation and invasion by targeting radixin expression.

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Breast cancer risk factors and mammographic density among high-risk women in urban China

Cited by 57 publications

References 72 publications

Diagnostic Performance of Digital Breast Tomosynthesis for Breast Suspicious Calcifications From Various Populations: A Comparison With Full-field Digital Mammography

Diagnostic Performance of Digital Breast Tomosynthesis for Breast Suspicious Calcifications From Various Populations: A Comparison With Full-field Digital Mammography

Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women

miR‑200b regulates breast cancer cell proliferation and invasion by targeting radixin

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