Breast cancer risk by occupation and industry: Analysis of the CECILE study, a population‐based case–control study in France

Villeneuve, Sara; Févotte, Joëlle; Anger, Antoinette; Truong, Thérèse; Lamkarkach, Farida; Gaye, Oumar; Kerbrat, Pierre; Arveux, Patrick; Miglianico, Laurent; Imbernon, Ellen; Guénel, Pascal

doi:10.1002/ajim.20952

Cited by 49 publications

(46 citation statements)

References 53 publications

(53 reference statements)

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“…11 14-17 19 The gradient of high risk of breast cancer in occupational sectors with a high socioeconomic position (white collar) and low risk in low socioeconomic occupations (blue collar) has been reported in several previous studies. [10][11][12][13][14][15][16][17][18] Even if some of the excess risk is due to reproductive and lifestyle factors as the adjustments show, many studies, like ours, still detect a high risk for this group even after adjustments. A potential alternative explanation has been put forward by Pudrovska et al who discussed the life-course stress approach, where occupations with a high socioeconomic position have a higher level of job authority and are therefore more stressful.…”

Section: Discussionmentioning

confidence: 55%

“…All of them found that the reproductive and lifestyle factors explained only a minor part or no part of the difference between occupational groups. 11 14-17 19 However, one study only looked at premenopausal breast cancer, 19 some studies did not adjust for alcohol consumption [14][15][16] or physical activity, [14][15][16][17] and two studies lacked data on breast feeding 14 16 and HRT. 14 17 In addition, several studies had a case-control design, which increased the risk of biases such as recall bias.…”

Section: What This Paper Addsmentioning

confidence: 99%

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Female white-collar workers remain at higher risk of breast cancer after adjustments for individual risk factors related to reproduction and lifestyle

et al. 2017

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ObjectivesThe aim was to investigate the variation in risk of breast cancer between occupational groups with a focus on white-collar and blue-collar workers and to investigate to what extent the differences were explained by risk factors related to reproduction and lifestyle.MethodsBetween 1991 and 1996, 14 119 women born between 1923 and 1950 and residents of Malmö, Sweden, were included in this cohort study. Individual data on risk factors (eg, age, parity, age at first child, months of breast feeding per child, hormonal replacement therapy, physical activity, alcohol consumption, smoking, height and body mass index) and occupational history were assessed using a questionnaire. First-time diagnoses of invasive breast cancer were identified through the Swedish Cancer Registry up until 31 December 2013.ResultsA total of 897 women were diagnosed with breast cancer. Analyses adjusted for age showed an increased risk for white-collar workers compared with blue-collar workers and indicated higher risks in the occupational categories: professionals, administrative and bookkeeping than among women in sales, transportation, production and service work. This difference was only marginally attenuated after adjustment for an extensive set of risk factors related to reproduction and lifestyle.ConclusionReproductive and lifestyle factors explain only a minor part of the increased risk of breast cancer in white-collar workers. Further studies are needed to investigate the remaining factors for the difference in risk between occupational groups.

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Section: Discussionmentioning

confidence: 55%

Section: What This Paper Addsmentioning

confidence: 99%

Female white-collar workers remain at higher risk of breast cancer after adjustments for individual risk factors related to reproduction and lifestyle

et al. 2017

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“…In a French case-control study on occupation as a risk factor for breast cancer, an OR of 1.4 (CI 0.9 to 2.1) emerged for women employed for more than 10 years as nurses. An overall OR of 2.4 (CI 0.9 to 6.0) was reported in textile workers and 1.5 (CI 0.9 to 2.6) in tailors/dressmakers, with no information available on working time schedules of these occupational groups (26). In a nested case-control study from a cohort of Danish nurses, signifi cantly increased ORs ranging between 1.8 and 2.9 were found when work after midnight was compared with permanent day work (27).…”

Section: Studies Since the Iarc Assessmentmentioning

confidence: 95%

Shift Work and Cancer: State of Science and Practical Consequences

Yong

Nasterlack

2012

Archives of Industrial Hygiene and Toxicology

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In 2007, an expert Working Group convened by the IARC Monographs Programme concluded that shift work that involves circadian disruption is probably carcinogenic to humans (Group 2A). We scrutinised the epidemiological basis for this conclusion, with a focus on, but not limited to, breast and prostate cancers. We further considered practical consequences for shift workers in our industry against the background of new fi ndings. We carried out a literature search including the epidemiological studies cited by IARC and newer available literature on shift work and cancer. Since the IARC assessment, eleven new studies have emerged, ten of which have already been published, with inconclusive results. Heterogeneity of exposure metrics and study outcomes and emphasis on positive but non-signifi cant results make it diffi cult to draw general conclusions. Also, several reviews and commentaries, which have been published meanwhile, came to equivocal results. Published evidence is widely seen as suggestive but inconclusive for an adverse association between night work and breast cancer, and limited and inconsistent for cancers at other sites and all cancers combined. At this point in time it can not be ruled out that shift work including night work may increase the risk for some cancers in those who perform it. However, shift schedules can be organised in ways that minimise the associated health risks, and the risks may be further reduced through the implementation of structured and sustained health promotion programs specifi cally tailored to the needs of shift workers.

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“…This database contains a continuously updated set of information on the subjects of national economy, with the activities of the enterprises encoded according to the Polish Classification of Activities (Polska Klasyfikacja Działalności -PKD) further studies was expressed as follows: "more studies are needed to examine this potential risk in other professions and for other cancers" (Dr Cogliano, Head of the IARC Monographs Programme) [2,3]. Over the past 5 years, eight additional epidemiological studies have been reported, including: three investigations in nurses: a Norwegian nested case-control study on breast cancer [4], a Danish nested case-control study on breast cancer [5], an ovarian cancer in Nurses Health Study [6], as well as a breast cancer case-control study in Germany [7], and France -breast cancer case-control CECILE study [8], industrial males cohort in Japan -a study on prostate cancer [9], and females in China -a study on breast cancer [10]. Moreover, one registry-based linkage study was conducted in Scandinavian countries [11].…”

Section: Methodsmentioning

confidence: 99%

Night shift work characteristics and occupational co-exposures in industrial plants in Łódź, Poland

Pepłońska

Burdelak

Bukowska

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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Objectives: Night shift work involving circadian rhythm disruption has been classified by IARC as a probably carcinogenic to humans (Group 2A). Little is known about co-exposures of the night shift work in occupational settings. The aim of our study was to characterize night shift work systems and industrial exposures occurring in the manufacturing plants in Łódź, Poland, where night shift work system operates, with particular focus on potential carcinogens. Material and Methods: Data on the night shift work systems and hazardous agents were collected through survey performed in 44 enterprises. The identified hazardous agents were checked using the IARC carcinogen list, and the harmonized EU classification of chemical substances. We also examined databases of the Central Register of Data on exposure to substances, preparations, agents and technological processes showing carcinogenic or mutagenic properties in Poland. Results: The most common system of work among studied enterprises employed 3 (8-hour) shifts within a 5-day cycle. We identified as many as 153 hazards occurring in the environment of the plants, with noise, carbon monoxide and formaldehyde recorded as the most common ones. Out of these hazards, 11 agents have been classified by IARC to group 1 -carcinogenic to humans, whereas 10 agents have been classified as carcinogens by the regulation of European Classification of carcinogens. Analysis of the data from the Central Register revealed that 6 plants reported presence of carcinogens in the environment of work. Conclusions: In our study we observed that in none of the workplaces the night shift work was a single exposure. Further epidemiological studies focusing on investigation of health effects of the night shift work should identify occupational co-exposures and examine them as potential confounders.

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Breast cancer risk by occupation and industry: Analysis of the CECILE study, a population‐based case–control study in France

Abstract: These findings suggest a possible role of occupational exposures in breast cancer, including night-shift work, solvents and endocrine disrupting chemicals and require further studies with detailed assessment of occupational exposures.

Cited by 49 publications

References 53 publications

Female white-collar workers remain at higher risk of breast cancer after adjustments for individual risk factors related to reproduction and lifestyle

Female white-collar workers remain at higher risk of breast cancer after adjustments for individual risk factors related to reproduction and lifestyle

Shift Work and Cancer: State of Science and Practical Consequences

Night shift work characteristics and occupational co-exposures in industrial plants in Łódź, Poland

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