Breast cancer Properties of Extract of Artemisia absinthium

Abstract

Plants have been used for the treatment of various cancers since ancient times. Breast cancer is the second commonest global deadly menace. Natural plant extracts, herbal medicines, are generally accepted as safer drug substances than their synthetic counterparts. Artemisia absinthium, a perennial bushy plant, has traditionally been beneficial in diverse maladies, including hepatocyte overgrowth, hepatitis, gastritis, jaundice, wound healing, splenomegaly, dyspepsia, indigestion, bloating, stomach pain, anaemia and anorexia. It has also been known for its antioxidant, antifungal, antimicrobial, anthelmintic, anti-ulcer, anticarcinogenic, hepatoprotective, neuroprotective, antidepressant, analgesic, immunomodulatory, and cytotoxic properties. In this study, methanol extracts of powdered leaves of Artemisia absinthium was tried on breast cancer cells. The molecular content of the extract was determined by GC-MS. Chemical components were determinated for the Artemisia absinthium extract, and the inhibitory activities of these chemicals against the Crystal structure of breast cancer protein (PDB ID: 1A52 and 1JNX) downloaded from the Protein Data Bank site were compared.