Breast Cancer Overview

Ely, Susan F.; Vioral, Anna N.

doi:10.1097/01.psn.0000290281.48197.ae

Cited by 23 publications

(20 citation statements)

References 4 publications

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“…The conventional ultrasound is more often used to determine whether an area of concern on the mammogram or clinical exam is cystic or solid. The majority of cystic masses are benign while solid masses need further evaluation [6]. Many indications for clinical breast MRI are recognized.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of benign and malignant breast lesions by mechanical imaging

Egorov

Kearney

Pollak

et al. 2009

Breast Cancer Res Treat

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Mechanical imaging yields tissue elasticity map and provides quantitative characterization of a detected pathology. The changes in the surface stress patterns as a function of applied load provide information about the elastic composition and geometry of the underlying tissue structures. The objective of this study is the clinical evaluation of breast mechanical imager for breast lesion characterization and differentiation between benign and malignant lesions. The breast mechanical imager includes a probe with pressure sensor array, an electronic unit providing data acquisition from the pressure sensors and communication with a touch-screen laptop computer. We have developed an examination procedure and algorithms to provide assessment of breast lesion features such as hardness related parameters, mobility, and shape. A statistical Bayesian classifier was constructed to distinguish between benign and malignant lesions by utilizing all the listed features as the input. Clinical results for 179 cases, collected at four different clinical sites, have demonstrated that the breast mechanical imager provides a reliable image formation of breast tissue abnormalities and calculation of lesion features. Malignant breast lesions (histologically confirmed) demonstrated increased hardness and strain hardening as well as decreased mobility and longer boundary length in comparison with benign lesions. Statistical analysis of differentiation capability for 147 benign and 32 malignant lesions revealed an average sensitivity of 91.4% and specificity of 86.8% with a standard deviation of ±6.1%. The area under the receiver operating characteristic curve characterizing benign and malignant lesion discrimination is 86.1% with the confidence interval ranging from 80.3 to 90.9%, with a significance level of P = 0.0001 (area = 50%). The multisite clinical study demonstrated the capability of mechanical imaging for characterization and differentiation of benign and malignant breast lesions. We hypothesize that the breast mechanical imager has the potential to be used as a cost effective device for cancer diagnostics that could reduce the benign biopsy rate, serve as an adjunct to mammography and to be utilized as a screening device for breast cancer detection.

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Section: Introductionmentioning

confidence: 99%

Differentiation of benign and malignant breast lesions by mechanical imaging

Egorov

Kearney

Pollak

et al. 2009

Breast Cancer Res Treat

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“…Breast cancer is one of the most common types of cancer in women and the second cause of cancer-related deaths after lung cancer (Ely and Vioral, 2007). As such in several different types of cancer, the development of breast cancer is thought to occur through a multistep mechanism.…”

Section: Introductionmentioning

confidence: 99%

“…The treatment options for breast cancer include surgery, radiotherapy, chemotherapy and hormonal therapy (Ely and Vioral, 2007). Chemotherapy is used to minimize the tumor and remove the metastasis focuses that may reach distant tissues and organs (Mycek et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Sister chromatid exchanges in breast cancer patients who underwent chemotherapy

2012

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-The study aimed to determine the effects of cytostatic and genotoxic drugs used to treat breast cancer on sister chromatid exchange (SCE). SCE values were examined in 25 female patients with breast cancer in pre-treatment, treatment process and remission period as well as in 22 nonsmoker women via peripheral blood culture technique. The SCE values of patient and control group were analyzed via "Mann-Whitney U test". Whilst SCE values of patient group were 8.25 ± 3.67, 10.19 ± 2.95 and 11.52 ± 3.33 in pre-treatment, treatment process and remission periods respectively, it was 7.01 ± 1.24 in control group. When overall SCE values of patients group in pre-treatment period were compared with those of control group, no significant difference was observed (p > 0.05), whereas highly significant differences were observed between treatment process and remission period of patient groups and control group in terms of SCE values (p < 0.01). If patients are exposed to any cytostatic and clastogenic drugs, the increase in the exchange values was considered remarkable. These findings reinforced the availability of sister chromatid exchange technique in directing of treatment and monitoring the genetic abnormalities caused by genomic instability which may occur due to the drugs used for treatment.

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“…For example, it is used to acquire further information when there is a palpable mass in the breast examination, a mass is identified in mammography or the breast is dense (31). However, it has today come to be used as a screening tool; there is a conception that cystic lesions are mostly considered benign whereas solid masses require additional studies (32). In conclusion, MRI is being used at a paramount frequency for the diagnosis of breast cancer (33).…”

Section: Discussionmentioning

confidence: 99%

How Many of the Biopsy Decisions Taken at Inexperienced Breast Radiology Units Were Correct?

2017

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Objective: In this study, we aimed to determine the need for biopsy in patients referred from other clinics for the performance of biopsy with the suspicion of breast cancer. Materials and Methods:112 patients were included in the study. It was decided that their biopsies be performed following examinations in other clinics and they presented to the breast radiology unit of our hospital for a second opinion. The demographic characteristics, diagnostic studies completed in the other centers, properties of lesions, decision made as a result of examinations and BI-RADS (Breast Imaging Reporting and Data Systems) categorizations were recorded on the registration forms of the study patients. In addition, the quality of examinations, reasons of repeat tests, additional tests features and the last decision of our clinic were documented. The obtained data were analyzed in terms of re-examination, additional tests and change in the biopsy decision. Changes in the biopsy decisions for patients were specifically inquired. Results:The biopsy decisions were cancelled in our breast radiology unit for 63 out of 112 patients (56.3%) whose biopsy decisions were made at an external institute. For 42 patients, examinations made by the other clinics were deemed adequate, yet there was no need for biopsy in 22 of them. The biopsy decisions were cancelled for 27 out of 47 patients (57.4%) with repeat examination and 18 out of 28 patients (64.3%) with additional tests because of the insufficient test quality. Conclusion:Incorrect, inadequate breast screening and false positivity were higher at inexperienced institutes.

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Breast Cancer Overview

Cited by 23 publications

References 4 publications

Differentiation of benign and malignant breast lesions by mechanical imaging

Differentiation of benign and malignant breast lesions by mechanical imaging

Sister chromatid exchanges in breast cancer patients who underwent chemotherapy

How Many of the Biopsy Decisions Taken at Inexperienced Breast Radiology Units Were Correct?

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