Breast Cancer Occurring in the Chest Wall: Rare Presentation of Ectopic Milk Line Breast Cancer

Wysokinska, Ewa M.; Keeney, Gary L.

doi:10.1200/jco.2012.47.8958

Cited by 7 publications

(6 citation statements)

References 15 publications

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“…Ectopic breast cancer was found 20 years after left mastectomy because of about two weeks of pain associated with a small lump located on the right, i.e. contralateral anterior chest on the lower aspect of the rib cage, 2 cm below proper breast [6]. In the case reported by Randy et al, ABT was located in the left upper abdomen, and the patient's mammogram seemed to correspond to the fifth or sixth pair of William's diagram; the final diagnosis was inflammatory breast cancer [7,18].…”

Section: Discussionmentioning

confidence: 99%

“…In 1891, Williams presented a diagram showing the mammary arrangement of early human progenitors, who had at least seven pairs of breasts on the ventral aspect of the trunk. His diagram is nearly identical to the milk line or mammary ridge along which later researchers usually located ABT [ 1 , 2 , 5 , 6 ]. Our case corresponds to the fifth pair in his diagram, i.e., just below and slightly medial to the normal female breast.…”

Section: Discussionmentioning

confidence: 99%

“…It varies according to ethnicity, sex, geographic region, and the method used to determine the presence of ABT. East Asian populations, including Japanese, are believed to have a higher incidence of ABT than Caucasians [ 5 , 6 , 8 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…We found six case reports of ABC in the inframammary or upper abdominal region [ 1 , 3 , 6 , 16 – 18 ]. Madej et al reported a case of advanced cancer (pT4N1M0: stage IIIB) [ 16 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Accessory breast cancer in the inframammary region: a case report and review of the literature

et al. 2021

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Background Although a few cases of accessory breast cancer (ABC) have been reported, most were in the axillary region. We encountered an extremely rare case of ABC in the inframammary region (IMR). Case presentation The patient was a 68-year-old postmenopausal woman who had noticed a congenital accessory nipple in her left IMR with slight, occasional discharge 20 years ago. Recently, she noticed a mass under the accessory nipple and visited a nearby clinic; fine-needle aspiration cytology of the mass revealed that it was malignant. She presented to our department 2 weeks after she had noticed the mass. Physical and imaging examinations showed an irregular tumor mass 1.7 × 1.4 × 1.0 cm in size connected to the accessory nipple beneath the left normal breast. Neither distant metastasis nor lymph node swelling was observed. Ultrasound-guided core needle biopsy revealed the mass to be invasive ductal carcinoma. We diagnosed her tumor as ABC in the left IMR; cT1cN0M0: stage IA. Curative wide resection with sentinel node biopsy was performed. Intraoperative evaluation of the frozen section revealed a hot and green ipsilateral axillary lymph node that was free from carcinoma; therefore, nodal dissection was avoided. Histopathological examination including immunochemical staining revealed that the tumor was invasive ductal carcinoma arising from the accessory breast tissue, scirrhous type, 1.7 × 1.4 × 1.0 cm in size, with a solid intraductal component. There was no lymphovascular infiltration, and the surgical margin was 1.5 cm or more. The tumor was estrogen and progesterone receptor-positive, Her2/neu-negative, and had a Ki-67 labeling index of 20%. There was no involvement of the three hot and/or green nodes. The final classification was pT1cN0(sn)M0: stage IA. Letrozole 2.5 mg/day will be administered for 5 years as adjuvant hormonal therapy. Conclusions A cutaneous and/or subcutaneous lesion except for proper breast tissue on the milk line, or mammary ridge from axilla to groin may be an accessory breast tissue. Its serial abnormalities must be worried malignant potential to ductal carcinoma which needs some imaging and pathological examinations for definitive diagnosis and appropriate treatment according to the usual orthotopic breast cancer without delay.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…We found six case reports of ABC in the inframammary or upper abdominal region [ 1 , 3 , 6 , 16 – 18 ]. Madej et al reported a case of advanced cancer (pT4N1M0: stage IIIB) [ 16 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Accessory breast cancer in the inframammary region: a case report and review of the literature

et al. 2021

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“…The incidence of accessory breast tissue is 2% to 6% in the general population and is more frequent in women [ 4 ]. The most common location of ectopic breast tissue is the axilla, with different frequencies reported for other locations along the milk line, including parasternal, subclavicular, submammary, and vulvar sites [ 5 ]. There are two forms of ectopic breast tissue, supernumerary breasts and aberrant breast tissue.…”

Section: Discussionmentioning

confidence: 99%

Ectopic Male Breast Cancer in the Perineum: A Case Report

Eom

Song

et al. 2017

J Breast Cancer

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Ectopic breast tissue and male breast cancer are both very rare diseases with only a few reports in the literature. Here, we present the first case of ectopic male breast cancer in the perineum. The patient was a 70-year-old man with a palpable mass in the perineum. A wide local excision and inguinal lymph node dissection revealed invasive breast carcinoma of no special type involving the skin and subcutis, and inguinal lymph node metastases. Immunohistochemical staining showed that the tumor cells were strongly positive for estrogen and progesterone receptors and negative for human epidermal growth factor receptor 2. Moreover, no p53 overexpression was observed. Herein, the clinical and pathologic features, as well as a review of ectopic male breast cancer are discussed.

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Treatment and Long-Term Risks for Patients With a Diagnosis of Ductal Carcinoma In Situ

Snodgrass¹

2016

JAMA Oncol

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Breast Cancer Occurring in the Chest Wall: Rare Presentation of Ectopic Milk Line Breast Cancer

Cited by 7 publications

References 15 publications

Accessory breast cancer in the inframammary region: a case report and review of the literature

Accessory breast cancer in the inframammary region: a case report and review of the literature

Ectopic Male Breast Cancer in the Perineum: A Case Report

Treatment and Long-Term Risks for Patients With a Diagnosis of Ductal Carcinoma In Situ

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