Breast Cancer Mortality in the Americas and Australasia over the Period 1980–2017 with Predictions for 2025

Wojtyła, Cezary; Bertuccio, Paola; Ciebiera, Michał; Vecchia, Carlo La

doi:10.3390/biology10080814

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…According to Wojtyla et al, BC death rates are not decreasing in LA countries. For women aged 20–49 years, low mortality rates are observed only in Chile and Cuba, while an increase in mortality is observed in the rest of the LA countries [ 36 ]. Although the incidence of BC is higher in the US and European populations, the mortality–incidence ratio is higher for LA, as described by Dutil et al [ 37 ]…”

Section: Discussionmentioning

confidence: 99%

DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review

Urbina-Jara

Martinez-Ledesma

Rojas-Martínez

et al. 2021

IJMS

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The prevalence of breast cancer in young women (YWBC) has increased alarmingly. Significant efforts are being made to elucidate the biological mechanisms concerning the development, prognosis, and pathological response in early-onset breast cancer (BC) patients. Dysfunctional DNA repair proteins are implied in BC predisposition, progression, and therapy response, underscoring the need for further analyses on DNA repair genes. Public databases of large patient datasets such as METABRIC, TCGA, COSMIC, and cancer cell lines allow the identification of variants in DNA repair genes and possible precision drug candidates. This study aimed at identifying variants and drug candidates that may benefit Latin American (LA) YWBC. We analyzed pathogenic variants in 90 genes involved in DNA repair in public BC datasets from METABRIC, TCGA, COSMIC, CCLE, and COSMIC Cell Lines Project. Results showed that reported DNA repair germline variants in the LA dataset are underrepresented in large databases, in contrast to other populations. Additionally, only six gene repair variants in women under 50 years old from the study population were reported in BC cell lines. Therefore, there is a need for new approaches to study DNA repair variants reported in young women from LA.

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Section: Discussionmentioning

confidence: 99%

DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review

Urbina-Jara

Martinez-Ledesma

Rojas-Martínez

et al. 2021

IJMS

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“…As maiores diminuições na mortalidade foram observadas na Austrália. As tendências de mortalidade nos países asiáticos permaneceram entre as mais baixas do mundo (Wojtyla et al, 2021b).…”

Section: Resultsunclassified

Análise da mortalidade por câncer de mama no Brasil e regiões, 2005 a 2019

Nogueira

Kluthcovsky

2022

RSD

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Esse estudo teve como objetivos analisar as taxas e a tendência de mortalidade por câncer de mama em mulheres, no Brasil e regiões, no período de 2005 a 2019. Trata-se de um estudo ecológico, de séries temporais. Foram analisadas as taxas de mortalidade por câncer de mama em pacientes do sexo feminino no Brasil no período de 2005 a 2019. Os dados foram obtidos mediante a consulta do Atlas On-line de Mortalidade por Câncer, disponibilizados pelo Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) no site do Departamento de Informática do Sistema Único de Saúde (DATASUS). Os dados são apresentados na forma descritiva e através de tabelas. A análise estatística foi obtida com auxílio do programa Statistical Package for Social Sciences (SPSS), versão 15.0. O nível de significância estatística adotado foi de 5%. As Regiões Sudeste e Sul apresentaram as maiores taxas de mortalidade ajustadas e a Região Norte as menores taxas. As taxas aumentaram com o aumento da idade. Foi observado uma tendência de aumento significativo da mortalidade para o Brasil e todas as regiões, durante os anos pesquisados. Enfatiza-se a necessidade de medidas de prevenção para os fatores de risco para o câncer de mama, bem como políticas sociais e de saúde específicas para o controle do câncer de mama no Brasil e redução da mortalidade.

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“…Breast cancer has been the leading cause of female cancer-related deaths in the Russian Federation, Ukraine, and Israel, whereas it ranks second after lung in Australia over the last decade. In these high mortality countries, predicted declining trends likely account for advancements in diagnosis and treatment, rather than a decrease in exposure to risk factors (Duggan et al , 2021; Wojtyla et al , 2021). Flattening predicted trends in Israel could reflect a greater prevalence of inherited mutations in Israeli women associated with aggressive and early breast cancer development (Walsh et al , 2017).…”

Section: Discussionmentioning

confidence: 99%

Cancer mortality and predictions for 2022 in selected Australasian countries, Russia, and Ukraine with a focus on colorectal cancer

Pizzato

Vecchia

Malvezzi

et al. 2022

European Journal of Cancer Prevention

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Objective We aimed at predicting cancer mortality rates for the current year for the Russian Federation, Ukraine, Israel, Hong Kong SAR, Japan, Korea, and Australia, with a focus on colorectal cancer. Methods We retrieved official death certification and population data from the WHO and the United Nations Population Division databases. We analyzed mortality for all cancers combined and for 10 major cancer sites from 1970 to 2019, or the latest available year. We predicted numbers of deaths and age-standardized mortality rates for 2022 using Poisson joinpoint regression models. We estimated the number of averted deaths over the period 1994–2022 because of the decline in mortality rates. Results Total cancer mortality declined in all countries and both sexes. Russia had the highest total cancer predicted rates for 2022: 156.4/100 000 (world standard) in men and 81.4 in women; the lowest rates were reported in Israeli men (90.6/100 000) and Korean women (44.5/100 000). Between 1994 and 2022, a total of 1 487 000 deaths were estimated to be avoided in Russia, 502 000 in Ukraine, 58 000 in Israel, 102 000 in Hong Kong SAR, 1 020 000 in Japan, 533 000 in the Republic of Korea, and 263 000 in Australia. Colorectal cancer mortality trends were downward for the last decades with favorable predictions for 2022 in both sexes. Conclusion In the countries considered, predicted downward trends started later and were less marked than those in the European Union and the USA. Despite overall favorable predictions, colorectal cancer remains one of the major causes of cancer mortality.

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Breast Cancer Mortality in the Americas and Australasia over the Period 1980–2017 with Predictions for 2025

Cited by 7 publications

References 39 publications

DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review

DNA Repair Genes as Drug Candidates for Early Breast Cancer Onset in Latin America: A Systematic Review

Análise da mortalidade por câncer de mama no Brasil e regiões, 2005 a 2019

Cancer mortality and predictions for 2022 in selected Australasian countries, Russia, and Ukraine with a focus on colorectal cancer

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