Breast cancer metastasizing to the stomach mimicking primary gastric cancer: A case report

Abstract

Breast cancer with stomach metastasis rare with an incidence of 1% or less among metastatic breast cancer patients. We experienced a case of breast cancer metastasizing to the stomach in 65-year-old female patient. She experienced dyspepsia and poor oral intake before visiting the clinic. Diffuse infiltration with nodular mucosal thickening of the stomach wall was observed, suggesting advanced gastric cancer based on gross endoscopic finding. Spread of poorly cohesive tumor cells in the gastric mucosa observed upon hematoxylin and eosin stain resembled signet ring cell carcinoma, but diffuse positive staining for GATA3 in immunohistochemical stain allowed for a conclusive diagnosis of breast cancer metastasizing to the stomach. Based on the final diagnosis, systemic chemotherapy was administered instead of primary surgical resection. After 2 cycles of docetaxel administration, she showed a partial response based on abdominal computed tomography scan. This case is an unusual presentation of breast cancer metastasizing to the gastrointestinal tract.

Gastrointestinal Tract Metastases of Invasive Lobular Carcinoma of the Breast: An Immunohistochemical Survey Algorithm

“…Patients with breast cancer very rarely have isolated GIT metastases. On the contrary, in almost all of them, multiple metastases are observed, most commonly in the bone (about 60%) before or simultaneously with the GIT metastasis (5,(7)(8)(9)(10)(11)17). This perhaps causes clinicians to focus on the more common metastases with more prominent symptoms and may result in failure to recognize possible GIT metastases.…”

“…Isolated GIT metastasis of ILC is extremely rare and at least 60% of ILC patients with GIT metastases have had concurrent bone (7,8) and, less frequently, other organ metastasis (5,(9)(10)(11). The pattern of metastasis is often diffuse and infiltrative so that it essentially presents as multiple erosions (7,8) or often linitis plastica type in the stomach (6,7,12).…”

Manejo Nutricional em Paciente com Metástase Gástrica de Câncer de Mama: um Relato de Caso

“…de acordo com a literatura, a incidência de metástase gástrica oriunda do tumor de mama é de 1% ou menos 3 . esse sítio metastático, quando presente, é quase sempre diagnosticado em estágios mais avançados, momento em que as terapêuticas, capazes de modificar o curso da doença, perdem efetividade e o cuidado paliativo ganha maior importância 4 .…”

Unusual coexistence of Ménétrier disease with adenocarcinoma of the esophagogastric junction: A case report and review of the literature

“…Several esophageal/gastric lesions including diffuse heterotopic gastric glands and granular cell tumors [1], esophageal [2] and gastric [3] tuberculosis, metastases of other primary cancers like breast [4] and lung cancer [5] were reported to mimic advanced esophageal/gastric cancer or adenocarcinoma of the esophagogastric junction (AEG).…”