Breast Cancer Metastasis to the Colon and Rectum: Review of Current Status on Diagnosis and Management

Abstract

Approximately 5-10% of patients will harbor distant metastasis at the time of breast cancer diagnosis with about a third of these patients developing distant recurrence after optimal therapy. Breast cancer has an unusual metastatic pattern to the colon and rectum with incidence that may be underappreciated. Lobular breast cancer has a higher preponderance to this unusual metastatic pattern. Clinical manifestation is nonspecific with a long latency period and diagnosis requires a high index of suspicion. The management is not clearly defined. However, medical management with chemo and hormonal therapy seem to be favored likely because of overall metastatic burden at time of diagnosis. Radical colonic resection in selected patients with isolated colorectal metastasis has been well tolerated and may influence survival. A regimented screening colonoscopy in breast cancer patients with high-risk features may offer early diagnosis and

MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An In silico Approach

“…44,45 Several studies suggest that mutations in genes involved in BC (BRCA1 and BRCA2) are also susceptible to cause CC. 46,47 Moreover, ROBO1 and CHEK2 mutations are also observed in both BC and CC. 48 SOCS3, a tumor suppressor gene, is associated with BC and CC development and progression due to its downregulation that results in dysregulation of JAK/STAT pathway.…”