Breast Cancer Metastasis Masquerading as Primary Colon and Gastric Cancer: A Case Report

Abstract

Unusual clinical course Background: Breast cancer is the most common malignancy in women worldwide. Despite treatment, recurrence and metastasis are common. Lobular breast cancer most commonly metastasizes to the lungs, liver, lymph nodes, and sites in the brain. Metastasis to the gastrointestinal tract is rare, with few cases reported to date. Case Report: This report describes a patient with late colon and gastric metastases from lobular breast cancer mimicking primary colon and gastric cancers. Conclusions: Immunohistochemical methods can help differentiate metastatic breast disease to the gastrointestinal tract from primary gastrointestinal malignancy.

Breast Metastasis Of Signet Ring Cell Carcinoma From The Colon: A Case Report

“…Moreover, immunohistochemistry for cytokeratin 20 (CK-20) and caudal-type homeobox 2 (CDX2) can accurately identify colon adenocarcinoma origin [3]. Cytokeratin 7 (CK-7) is positive for most breast cancers, but negative for colon cancer [11]. In this case, the patient's immunohistochemistry of the breast showed that CK-20 positive expression, CDX-2 weakly positive expression and CK-7 negative expression, which con rmed the intestinal tract origin.…”

Metastatic Infiltrating Lobular Breast Cancer to the Colon Diagnosed Through Routine Bowel Screening in a 60-Year-Old Female

“…Similarly, Noor and colleagues reported a case of a 68-year-old female with ILC BC, presenting 30 years after the initial diagnosis of BC, with symptoms of obstruction. CT confirmed circumferential narrowing and thickening in the distal sigmoid colon [ 8 ], and due to her history of BC, a decision was made to investigate with colonoscopy first. Colonoscopy revealed diffuse proliferation of neoplastic cells, with histochemistry confirmation of metastatic BC [ 8 ].…”

“…CT confirmed circumferential narrowing and thickening in the distal sigmoid colon [ 8 ], and due to her history of BC, a decision was made to investigate with colonoscopy first. Colonoscopy revealed diffuse proliferation of neoplastic cells, with histochemistry confirmation of metastatic BC [ 8 ]. Further investigation with endoscopy also revealed gastric metastasis.…”

“…Further investigation with endoscopy also revealed gastric metastasis. No surgical resection was performed, and she continued to receive hormonal therapy and passed away four years later due to the progression of the disease [ 8 ].…”

Hematemesis: An Exceptional Method of Revealing Gastric Metastasis From an Unknown Breast Cancer

“…Throughout the literature, the GI tract was rarely a preferred metastatic site for breast cancer in particular [ 10 ]. Thus Apodaca-Rueda M et al had reported a case of metastasis to the pancreatic level [ 11 ], Nour A et al, described a metastasis to both the colonic and gastric level initially taken as primary [ 12 ]. Other authors report digestive metastases of a breast primary discovered in a context of complication or emergencies like Théraux J et al who had described a colonic occlusion on a colonic tumor of breast origin [ 13 ] and Nehmeh WA et al had reported a secondary localization following a gastric perforation [ 14 ], while hematemesis revealed the diagnosis in our case.…”