Breast Cancer is Common in Women With Ovarian Malignant Mixed Mullerian Tumors

Whynott, Rachel M.; Manahan, Kelly J.; Geisler, John P.

doi:10.1097/coc.0000000000000266

Cited by 2 publications

(1 citation statement)

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“…B reast cancer is a common malignant tumor impacting female heath and lives. 1 In recent decades, the incidence of breast cancer has increased globally. 2 In western countries, breast cancer has become a leading cause of feminine malignant tumor death.…”

Section: Introductionmentioning

confidence: 99%

3.0 T Magnetic Resonance Functional Imaging Quantitative Parameters for Differential Diagnosis of Benign and Malignant Lesions of the Breast

Xue

Chen

Xia

et al. 2021

Cancer Biotherapy and Radiopharmaceuticals

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Objective: To investigate value of quantitative dynamic contrast-enhanced magnetic resonance imaging (MRI) parameters and apparent diffusion coefficient (ADC) value in differential diagnosis of breast benign and malignant lesions, and their correlation with prognostic factors of breast cancer. Methods: The study collected MRI images and clinical data from 232 female patients suspected of breast cancer. Philips INGENIA 3.0T superconducting magnetic resonance scanner was used for imaging examination. Complete pathological data of patients were collected, and the expression of ER, PR, HER-2, and Ki-67 were further investigated. Results: K ep was higher in malignant breast lesion group than that in benign breast lesion group, and ADC value was lower in the former group than that in the latter group (both p < 0.05). The areas under the receiver operating characteristic curves for K ep , ADC, and extravascular volume fraction (V e ) were 0.904 (95% confidence interval [CI]: 0.863-0.945), 0.813 (95% CI: 0.752-0.875), and 0.774 (95% CI: 0.707-0.841), respectively. Furthermore, according to the maximum Youden index, the specificity of K ep and the sensitivity of ADC were high, which were 97.20% and 96.00%, respectively, with a cutoff value of 0.314 and 0.151, respectively. K ep value in ER-positive expression group was significantly higher than that in ER-negative expression group ( p < 0.05). K ep value in PR-positive expression group was significantly higher than that in PR-negative expression group ( p < 0.05). There was positive correlation between K ep and expression of Ki-67 ( p < 0.05). ADC value was negatively correlated with Ki-67 expression ( p < 0.05). Conclusion: Quantitative parameters K ep and ADC of 3.0 T MR functional imaging can be used as reference indexes for differential diagnosis of benign and malignant breast lesions and for biological behavior evaluation, indicating potential clinical value for noninvasive preoperative evaluation of breast cancer.

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Section: Introductionmentioning

confidence: 99%