Breast Cancer in Women 70 Years of Age or Older

Masetti, Riccardo; Antinori, Armando; Terribile, Daniela; Marra, Alessandro; Granone, Pierluigi; Magistrelli, Paolo; Picciocchi, Aurelio

doi:10.1111/j.1532-5415.1996.tb06407.x

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…Indeed, several prognostic factors reflecting hormonal dependency, proliferative activity, and histology display favorable features with increasing age 15, 16. However, follow‐up studies of women with similar stages of disease at diagnosis who received equivalent treatment failed to demonstrate a survival advantage related to age 17, 18. Second, increased toxicity of adjuvant treatments in older patients could limit their use.…”

mentioning

confidence: 99%

Compliance with consensus recommendations for the treatment of early stage breast carcinoma in elderly women

Hébert‐Croteau¹,

Brisson

Latreille

et al. 1999

Cancer

183

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BACKGROUND The goal of this study was to assess variations with age in the management of breast carcinoma and to identify determinants of care received. METHODS A stratified random sample was selected among women age ≥ 50 newly diagnosed with lymph node negative breast carcinoma in Québec in 1988, 1991, and 1993. Information was abstracted from medical charts. Predictors of definitive locoregional treatment (total mastectomy with lymph node dissection or breast‐conserving surgery with both axillary lymph node dissection and radiation therapy) were identified by multiple logistic regression analysis. RESULTS Overall, 1174 patients age ≥ 50 years with breast carcinoma were included. Women age ≥ 70 years were much less likely to receive definitive locoregional treatment compared with women ages 50–69 years (48.7% vs. 83.5%; P < 0.0001). Older women were less likely to undergo surgery with breast preservation (76.7% vs. 86.3%; P < 0.0001), radiation therapy (54.7% vs. 90.5%; P < 0.0001), dissection of the axillary lymph nodes (55.6% vs. 86.3%; P < 0.0001), or chemotherapy (1.2% vs. 13.9%; P < 0.0001), but not treatment with tamoxifen (66.4% vs. 64.7%; P = 0.41). Adjusting for comorbidity and other characteristics related to the disease, the hospital, and the attending physician, age remained a strong determinant of the probability of receiving definitive locoregional treatment (odds ratio [OR], 0.14; 95% confidence interval [95% CI], 0.12–0.18 for women age ≥ 70 years vs. women ages 50–69 years). The same association was observed when women who did not undergo lymph node dissection but who received systemic adjuvant treatment were considered to have received definitive therapy (OR, 0.13; 95% CI, 0.10–0.17) for women age ≥ 70 years vs. women ages 50–69 years). CONCLUSIONS Less aggressive patterns of care are provided to elderly breast carcinoma patients, independent of comorbidity. This could explain, at least in part, the sustained breast carcinoma mortality in this population. Cancer 1999;85:1104–13. © 1999 American Cancer Society.

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mentioning

confidence: 99%

Compliance with consensus recommendations for the treatment of early stage breast carcinoma in elderly women

Hébert‐Croteau¹,

Brisson

Latreille

et al. 1999

Cancer

183

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“…failed to demonstrate a survival advantage related to age. 17,18 Second, increased toxicity of adjuvant treatments in older patients could limit their use. Except for chemotherapy, 19 however, most reports on that issue do not support this contention.…”

mentioning

confidence: 99%

Compliance with consensus recommendations for the treatment of early stage breast carcinoma in elderly women

Hébert‐Croteau¹,

Brisson²,

Latreille³

et al. 1999

Cancer

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“…However it is difficult to assess biological age or the life expectancy of an elderly person with accuracy. For breast cancer patients an arbitrary cut off of 70 years has been widely used, above which women were considered for tamoxifen‐only treatment 2 , a practice based on historical data. However a woman of 70 years or more can now be expected to live for substantially longer than those treated a few decades ago.…”

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confidence: 99%

Management of elderly patients with breast cancer: the time for surgery

Rai

Stotter

2005

ANZ Journal of Surgery

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Breast Cancer in Women 70 Years of Age or Older

Abstract: Treatment with curative intent, similar to that adopted in younger patients, is appropriate for women over the age of 70 with breast cancer.

Cited by 10 publications

References 22 publications

Compliance with consensus recommendations for the treatment of early stage breast carcinoma in elderly women

Compliance with consensus recommendations for the treatment of early stage breast carcinoma in elderly women

Compliance with consensus recommendations for the treatment of early stage breast carcinoma in elderly women

Management of elderly patients with breast cancer: the time for surgery

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