Breast cancer in the elderly: the role of adjuvant radiation therapy

Olmi, Patrizia; Fallai, C.; Cerrotta, A.; Lozza, Laura; Badii, Donatella

doi:10.1016/j.critrevonc.2003.05.004

Cited by 10 publications

(4 citation statements)

References 84 publications

(120 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well documented that a favorable molecular profile is observed more frequently in elderly BC patients [ 9 10 ]. This profile includes the expression of the estrogen (ER) and progesterone receptors (PR), decreased levels of cell proliferation markers [ 11 ], lower expression of human epidermal growth factor receptor 2 (HER2) [ 12 ], a higher frequency of diploids, a lower frequency of p53 mutations [ 13 ], and the overexpression of the B-cell lymphoma 2 (Bcl-2) protein [ 9 ].…”

Section: Breast Cancer Biomarkers In the Elderlymentioning

confidence: 99%

See 1 more Smart Citation

Early-Stage Breast Cancer in the Elderly: Confronting an Old Clinical Problem

et al. 2015

View full text Add to dashboard Cite

Breast cancer generally develops in older women and its incidence is continuing to increase with increasing age of the population. The pathology and biology of breast cancer seem to be different in the elderly, often resulting in the undertreatment of elderly patients and thus in higher rates of recurrence and mortal-ity. The aim of this review is to describe the differences in the biology and treatment of early breast cancer in the elderly as well as the use of geriatric assessment methods that aid decision-making. Provided there are no contraindications, the cornerstone of treatment should be surgery, as the safety and efficacy of surgical resection in elderly women have been well documented. Because most breast cancers in the elderly are hormone responsive, hormonal therapy remains the mainstay of systemic treatment in the adjuvant setting. The role of chemotherapy is limited to patients who test negative for hormone receptors and demonstrate an aggressive tumor profile. Although the prognosis of breast cancer patients has generally improved during the last few decades, there is still a demand for evidence-based optimization of therapeutic interventions in older patients.

show abstract

Section: Breast Cancer Biomarkers In the Elderlymentioning

confidence: 99%

“…Another interesting finding is that early-stage BC is detected less frequently in elderly women than in younger patients [ 13 ]. For example, T1 tumors are observed in 70% of patients between 45 and 64 years old, but in only 47% of women over 75 years [ 18 ].…”

Section: Breast Cancer Biomarkers In the Elderlymentioning

confidence: 99%

Early-Stage Breast Cancer in the Elderly: Confronting an Old Clinical Problem

et al. 2015

View full text Add to dashboard Cite

show abstract

“…A successful BC prevention program is defined by its capacity to detect disease at its earlier stages. Regarding older patients, it was showed that early-stage BC is detected less frequently compared to younger women, essentially due to lack of screening (18). In their work, Molino et al have shown a rate of T1 tumors at diagnosis of 70% for BC patients between 45 and 64 years of age and of only 47% after 75 years (19).…”

Section: Discussionmentioning

confidence: 99%

Could Patients Older than 75 Years Benefit from a Systematic Breast Cancer Screening Program?

Ilenko¹,

Sergent²,

Mercuzot³

et al. 2017

View full text Add to dashboard Cite

show abstract

“…A retrospective analysis from a single-institution showed greater likelihood of distant metastases in a subgroup of elderly patients aged over 70 years compared to that in the younger patients [ 37 ]. In addition, another study also reported that breast cancer was often detected at far advanced stage in the elderly; only 47% of patients with breast cancer aged over 75 years were found to have T1 tumors, while 70% of patients aged between 45 and 64 years were found to have T1 tumor, probably due to the lack of screening or delayed diagnosis [ 38 – 40 ].…”

Section: Tumor Biology Of Elderly Breast Cancermentioning

confidence: 99%

Current Strategies of Endocrine Therapy in Elderly Patients with Breast Cancer

Lee

Seo

2018

BioMed Research International

View full text Add to dashboard Cite

Currently, the growing population of the elderly is one of biggest problems in terms of increase in geriatric diseases. Lack of data from large prospective studies on geriatric breast cancer patients often makes it difficult for clinicians to make treatments decisions for them. Because both benefit and risk of treatment should be taken into account, treatment is usually determined considering life expectancy or comorbidities in elderly patients. Treatment of breast cancer is differentiated according to histologic classifications, and hormone therapy is even adopted for patients with metastatic breast cancer if tumor tissue expresses hormone receptors. Endocrine therapy can offer great benefit to elderly patients considering its equivalent efficacy to chemotherapy with fewer toxicities if it is appropriately used. Aromatase inhibitors are usually prescribed agents in hormone therapy for elderly breast cancer patients due to their physiology after menopause. Here, endocrine therapy for elderly patients with breast cancer in neoadjuvant, adjuvant, and palliative setting is reviewed along with predictive adverse events resulting from the use of hormone agents.

show abstract

Breast cancer in the elderly: the role of adjuvant radiation therapy

Cited by 10 publications

References 84 publications

Early-Stage Breast Cancer in the Elderly: Confronting an Old Clinical Problem

Early-Stage Breast Cancer in the Elderly: Confronting an Old Clinical Problem

Could Patients Older than 75 Years Benefit from a Systematic Breast Cancer Screening Program?

Current Strategies of Endocrine Therapy in Elderly Patients with Breast Cancer

Contact Info

Product

Resources

About