Breast cancer in the elderly: Histological, hormonal and surgical characteristics

Pappo, Itzhak; Karni, Tamar; Sandbank, Judith; Dinur, Irit; Sella, Avishai; Stahl-Kent, Varda; Wasserman, Ilan; Halevy, Ariel

doi:10.1016/j.breast.2006.05.007

Cited by 36 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The proportion of patients with luminal, Her2+, and TN tumors was similar in the 2 age groups, in line with previous reports [7,19] . Tumor subtype affected OS and disease-free survival.…”

Section: Discussionsupporting

confidence: 81%

See 1 more Smart Citation

Early Breast Cancer in the Elderly: Characteristics, Therapy, and Long-Term Outcome

Gal

Ishai²,

Sulkes³

et al. 2017

Oncology

View full text Add to dashboard Cite

Objective: The number of older adults diagnosed with breast cancer is increasing. However, data on breast cancer characteristics, treatment, and survival in elderly women are sparse. Methods: The database of a tertiary cancer center was searched for all women aged ≥65 years who were diagnosed with early breast cancer in 2004-2007. Patients were divided into 2 age groups: 65-75 years and >75 years. Data on tumor, treatment, and outcome parameters were compared. Results: The cohort included 390 patients. The older group underwent more mastectomies but less axillary surgery or adjuvant systemic therapy. Median overall survival (OS) was 9.5 years in the older group and not reached in the younger group; the 8-year disease-free survival rates were 85 and 88%, respectively (p = 0.27). Both age and tumor subtype had an effect on OS and recurrence rates (p < 0.001 for OS; p = 0.16 for recurrence). The worst outcome was noted in women aged >75 years with triple-negative (TN) disease. Conclusion: The treatment approach was different between both age groups, despite similar tumor characteristics. TN subtype presented as the most aggressive disease in both age groups. Physicians should be alert to these findings and select treatment on a case-by-case basis.

show abstract

“…The proportion of patients with luminal, Her2+, and TN tumors was similar in the 2 age groups, in line with previous reports [7,19] . Tumor subtype affected OS and disease-free survival.…”

Section: Discussionsupporting

confidence: 81%

“…Indeed, patients in the older group may not have been referred for breast cancer screening at all given the recommended age limit for screening of 70-75 years. The comparable nodal status could suggest a different or more benign pattern of tumor progression in elderly patients [7,[19][20][21] .…”

Section: Discussionmentioning

confidence: 99%

Early Breast Cancer in the Elderly: Characteristics, Therapy, and Long-Term Outcome

Gal

Ishai²,

Sulkes³

et al. 2017

Oncology

View full text Add to dashboard Cite

show abstract

“…However, we found a significantly lower proportion of family cancer history among the elderly patients, which is in agreement with Pappo et al (13). The differences in pre-operative pathological diagnostic methods were also confirmed by our study.…”

Section: Discussionsupporting

confidence: 82%

Clinicopathological features and treatment sensitivity of elderly Chinese breast cancer patients

et al. 2010

Oncology Letters

View full text Add to dashboard Cite

Abstract. This study aimed to determine the clinicopathological features and treatment sensitivity of elderly breast cancer patients in China. The clinical data of 594 elderly breast cancer patients of 70 or more years of age were collected and compared to those of 657 patients of less than 70 years of age to analyze whether breast cancer in the elderly is different and whether the difference affected outcome. The median age was 75.2 years in the elderly patients and 49.8 years in the young patients. Age of menarche, parous status and body mass index were similar in the two groups. A higher frequency of steroid receptor-positive rate, a lower expression of HER-2 and p53, less axillary node-positive rate and earlier tumor stage were found in patients of 70 years or older. The 5-year relapse-free survival (RFS) and overall survival (OS) was 77 and 82% in the elderly and 86 and 93% in the young patients, respectively. Patients with estrogen receptor (ER)-positive or lymph node (LN)-negative cancers showed a more favorable outcome in the elderly patients. RFS and OS were increased in elderly patients who underwent endocrine therapy or omitted chemotherapy. Breast cancer in the elderly had more favorable tumor features, using estrogen receptor and lymph node status as prognostic factors. It was therefore concluded that adjuvant endocrine therapy may benefit elderly patients, while chemotherapy may not.

show abstract

“…Many studies have shown that breast cancer incidence and death rates generally increase with age (Gajdos et al, 1999; Colleoni et al, 2005;Pappo et al, 2007;Stankov, 2011). According to the American Cancer Society reports, 95% of new cases and 97% of breast cancer deaths was occurred in women 40 years of age and older.…”

Section: Discussionmentioning

confidence: 99%

Predictive Role of Tumor Size in Breast Cancer with Axillary Lymph Node Involvement - Can Size of Primary Tumor be used to Omit an Unnecessary Axillary Lymph Node Dissection?

Orang

Marzony²,

Afsharfard³

2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Breast cancer is the most common cancer among women worldwide. The aim of this study was to investigate the relationship between tumor size and axillary lymph node involvement (ALNI) in patients with invasive lesions, to find the best candidates for a full axillary dissection. Additionally, we evaluated the association between tumor size and invasive behavior. The study was based on data from 789 patients with histopathologically proven invasive breast cancer diagnosed in Shohada University hospital in Tehran, Iran (1993-2009). Cinical and histopathological characteristics of tumors were collected. Patients were divided into 6 groups according to primary tumor size: group I (0.1-≤1cm), II (1.1-≤2cm), III (2.1-≤3cm), IV (3.1-≤4cm), V (4.1-≤5cm) and VI (>5cm). The mean(±SD) size of primary tumor at the time of diagnosis was 3.59±2.69 cm that gradually declined during the course of study. There was a significant correlation between tumor size and ALNI (p<0.001). A significant positive correlation between primary tumor size and involvement of surrounding tissue was also found (p<0.001). The mean number of LNI in group VI was significantly higher than other groups (p<0.05).We observed more involvement of lymph nodes, blood vessels, skin and areola-nipple tissue with increase in tumor size.We found 15.3% overall incidence of ALNI in tumors ≤2 cm, indicating the need for more investigation to omit full axillary lymph node dissection with an acceptable risk for tumors below this diameter. While in patients with tumors ≥2 cm, 84.3% of them had nodal metastases, so the best management for this group would be a full ALND. Tumor size is a significant predictor of ALNM and involvement of surrounding tissue, so that an exact estimation of the size of primary tumor is necessary prior to surgery to make the best decision for management of patients with invasive breast cancer.

show abstract

Breast cancer in the elderly: Histological, hormonal and surgical characteristics

Cited by 36 publications

References 23 publications

Early Breast Cancer in the Elderly: Characteristics, Therapy, and Long-Term Outcome

Early Breast Cancer in the Elderly: Characteristics, Therapy, and Long-Term Outcome

Clinicopathological features and treatment sensitivity of elderly Chinese breast cancer patients

Predictive Role of Tumor Size in Breast Cancer with Axillary Lymph Node Involvement - Can Size of Primary Tumor be used to Omit an Unnecessary Axillary Lymph Node Dissection?

Contact Info

Product

Resources

About