Breast Cancer in Previously Thyroidectomized Patients: Which Thyroid Disorders are a Risk factor?

Graceffa, Giuseppa; Scerrino, Grégorio; Militello, Gabriella; Laise, Iole; Randisi, Brenda; Orlando, G.; Mazzola, S; Cipolla, Calogero; Cocorullo, Gianfranco

doi:10.2144/fsoa-2021-0029

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…They postulated that iodine deficiency might be an important factor in the oncogenic process. Subsequently, other studies recruiting BC patients showed similar results, demonstrating that TPOAb were detected more frequently in BC patients than in the controls [ 88 , 89 , 90 , 91 , 92 ]. Giustarini [ 90 ] detected TPOAb in 36 BC patients, 25 with breast benign disease (BBD) and 100 healthy women.…”

Section: Autoimmune Thyroid Disease and Bcsupporting

confidence: 53%

Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions

Liu

Zheng

et al. 2022

Cancers

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Breast and thyroid glands are two common sites of female malignancies. Since the late 19th century, physicians have found that the cancers in either thyroid or mammary gland might increase the risk of second primary cancers in the other site. From then on, many observational clinical studies have confirmed the hypothesis and more than one theory has been developed to explain the phenomenon. Since the two glands both have secretory functions and are regulated by the hypothalamic–pituitary axis, they may share some common oncogenic molecular pathways. However, other risks factors, including medical interventions and hormones, are also observed to play a role. This article aims to provide a comprehensive review of the associations between the two cancers. The putative mechanisms, such as hormone alteration, autoimmune attack, genetic predisposition and other life-related factors are reviewed and discussed. Medical interventions, such as chemotherapy and radiotherapy, can also increase the risk of second primary cancers. This review will provide novel insights into the research designs, clinical managements and treatments of thyroid and breast cancer patients.

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Section: Autoimmune Thyroid Disease and Bcsupporting

confidence: 53%

Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions

Liu

Zheng

et al. 2022

Cancers

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“…Interestingly, as our review reported, the phenomenon of increased genetic instability and reduction of tumor immunity in multiple cancer patients was confirmed by the case of the woman with medullary, papillary, and RCC (32), a very rare combination, where even if the patient had no previous endocrine history, her mother was affected by breast cancer, another disease deeply connected to TC (4,(45)(46)(47) and the brother presented with RCC, too. A triple malignant tumor was also reported in a male of the same age with thyroid, kidney, and colon being affected (31), demonstrating common expression paths with integrin avß6 in multiple primary cancer (29).…”

Section: Discussionmentioning

confidence: 70%

Thyroid and renal cancers: A bidirectional association

Bellini

Lori

Forte³

et al. 2022

Front. Oncol.

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There is a deep interrelation between the thyroid gland and the kidney parenchyma, with dysfunction of the first leading to significant changes in renal metabolism and vice versa. Given the recognition of cancer as a systemic disease, the raise of thyroid tumors and the common association of several malignancies, such as breast cancer, prostate cancer, colorectal cancer, and other, with an increased risk of kidney disease, public health alert for these conditions is warranted. A systematic review of the current evidence on the bidirectional relationship between thyroid and renal cancers was conducted including 18 studies, highlighting patient’s characteristics, histology, time for secondary malignancy to develop from the first diagnosis, treatment, and follow-up. A total of 776 patients were identified; median age was 64 years (range: 7–76 years). Obesity and family history were identified as the most common risk factors, and genetic susceptibility was suggested with a potential strong association with Cowden syndrome. Controversy on chemo and radiotherapy effects was found, as not all patients were previously exposed to these treatments. Men were more likely to develop kidney cancer after a primary thyroid malignancy, with 423/776 (54%) experiencing renal disease secondarily. Median time after the first malignancy was 5.2 years (range: 0–20 years). With the advancement of current oncological therapy, the prognosis for thyroid cancer patients has improved, although there has been a corresponding rise in the incidence of multiple secondary malignancy within the same population, particularly concerning the kidney. Surgery can achieve disease-free survival, if surveillance follow-up allows for an early localized form, where radical treatment is recommended.

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“…Studies aimed at defining the association between BC and benign TD, in particular AITD, have produced conflicting results causing a long-lasting debate [153][154][155][156][157][158][159][160][161][162][163][164]. In 2002, Sarlis and colleagues performed a meta-analysis of 13 articles published over the previous 50 years including 14,226 women [153].…”

Section: Autoimmune Thyroid Disease (Aitd) and Breast Cancer (Bc)mentioning

confidence: 99%

Thyroid Diseases and Breast Cancer

Baldini

Lauro

Tripodi

et al. 2022

JPM

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Epidemiological studies aimed at defining the association of thyroid diseases with extra-thyroidal malignancies (EM) have aroused considerable interest in the possibility of revealing common genetic and environmental factors underlying disease etiology and progression. Over the years, multiple lines of evidence indicated a significant relationship between thyroid carcinomas and other primary EM, especially breast cancer. For the latter, a prominent association was also found with benign thyroid diseases. In particular, a meta-analysis revealed an increased risk of breast cancer in patients with autoimmune thyroiditis, and our recent work demonstrated that the odds ratio (OR) for breast cancer was raised in both thyroid autoantibody-positive and -negative patients. However, the OR was significantly lower for thyroid autoantibody-positive patients compared to the negative ones. This is in agreement with findings showing that the development of thyroid autoimmunity in cancer patients receiving immunotherapy is associated with better outcome and supports clinical evidence that breast cancer patients with thyroid autoimmunity have longer disease-free interval and overall survival. These results seem to suggest that factors other than oncologic treatments may play a role in the initiation and progression of a second primary malignancy. The molecular links between thyroid autoimmunity and breast cancer remain, however, unidentified, and different hypotheses have been proposed. Here, we will review the epidemiological, clinical, and experimental data relating thyroid diseases and breast cancer, as well as the possible hormonal and molecular mechanisms underlying such associations.

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Breast Cancer in Previously Thyroidectomized Patients: Which Thyroid Disorders are a Risk factor?

Cited by 5 publications

References 38 publications

Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions

Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions

Thyroid and renal cancers: A bidirectional association

Thyroid Diseases and Breast Cancer

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