Breast Cancer in Pregnancy

Krishna, Iris; Lindsay, Michael

doi:10.1016/j.ogc.2013.05.006

Cited by 23 publications

(34 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies, including a large review, concluded that surgery carries a similar probability of miscarriage to the background risk of spontaneous abortion, including first trimester. 7,18 Mastectomy is the definitive procedure. There is a trend for favouring breast-conserving surgery as a suitable option for PABC patients, and this should be discussed with the patient whenever possible.…”

Section: Surgerymentioning

confidence: 99%

See 1 more Smart Citation

Current management of pregnancy-associated breast cancer

Cheung

Leung

et al. 2017

Hong Kong Med J

View full text Add to dashboard Cite

A B S T R A C TPregnancy-associated breast cancer is the most common malignancy during pregnancy with an expected rise in incidence. The belief in the need for termination of pregnancy and that chemotherapy is contra-indicated during pregnancy is challenged by recent evidence. Patients can consider breastconserving surgery and sentinel lymph node biopsy with acceptably low fetal risk from radiation exposure. A range of chemotherapeutics is possible in the second trimester in terms of drug class and frequency. Hormonal therapy and monoclonal antibody therapy are contra-indicated during pregnancy and lactation. Fetal outcome after inutero exposure to chemotherapy appears similar to that in a non-pregnant population. Future pregnancy, in most situations, does not appear to be contra-indicated but a multidisciplinary and patient-centred approach is recommended. Fertility preservation techniques are also being developed Current management of pregnancy-associated breast cancer

show abstract

Section: Surgerymentioning

confidence: 99%

“…2 When the tumour is diagnosed at an early stage, however, a considerable proportion of patients will have node-negative disease and therefore might benefit from sentinel lymph node biopsy (SLNB). Such procedure remains controversial 18 but some studies have reported its success and safety.…”

Section: Surgerymentioning

confidence: 99%

Current management of pregnancy-associated breast cancer

Cheung

Leung

et al. 2017

Hong Kong Med J

View full text Add to dashboard Cite

show abstract

“…While the description of said treatment was not identified, this study did validate that therapeutic abortion or termination of pregnancy was not necessary for all patients prior to initiating cancer treatment [8]. Not only is termination not necessary, but some studies have also demonstrated a lack of survival benefit to the patient with termination of pregnancy prior to initiation of cancer treatment [1][2][3][4]7].…”

Section: Discussionmentioning

confidence: 75%

“…The incidence of breast cancer in pregnancy is reported to be between 1 in 3000 and 1 in 10,000 pregnancies. As more women delay childbearing, the incidence of breast cancer in pregnancy is expected to increase, with women over the age of 35 being at greatest risk [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Current recommendations for initial prenatal physical examinations include a complete bilateral breast examination which should be repeated at the 6 week postpartum visit as well as any time throughout the antepartum period in which the patient notices a change on selfexamination [4]. Breast masses encountered in pregnancy are mainly benign, with the differential diagnosis including abscess, lipoma, lactating adenoma, fibrocystic disease, hamartoma, and milk retention cyst.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Importance of a Multidisciplinary Approach to Breast Cancer Treatment in Pregnancy: Case Report of New Diagnosis of Pregnancy-Associated Breast Cancer

Grant¹,

DiCarlo²,

Woessner-Hoyson³

2016

J Carcinog Mutagen

View full text Add to dashboard Cite

Pregnancy-Associated Breast Cancer (PABC) is a rare diagnosis and includes new diagnoses of cancer both during pregnancy as well as within the first year post-delivery. Due to its rarity, there is of yet no gold standard treatment nor is there a standardized regimen of treatment during pregnancy according to the American College of Obstetrics and Gynecology (ACOG). We report a case involving a 35-year-old gravida 2 para 1-0-0-1 who was diagnosed with clinical stage II (T2 N1) breast cancer in the early third trimester of pregnancy after physical examination revealed a palpable mass. Ultrasound-guided biopsy revealed poorly differentiated infiltrating ductal carcinoma, nuclear grade 3, with micropapillary features, estrogen receptor (ER 90%), progesterone receptor (PR 25%) positive, HER2 positive 3+ with Ki67 index 75%. After extensive counseling and discussion between Obstetrics, Maternal Fetal Medicine, Breast Surgery, Neonatal ICU, and Oncology, a decision was made to initiate neoadjuvant chemotherapy (NAC) with adriamycin and cyclophosphamide. Our patient completed 4 total NAC treatments prior to delivery followed by a regimen of weekly taxol plus herceptin and perjeta postpartum. This patient strongly desired to carry the pregnancy to term and began treatment prior to delivery, making this case unique in comparison to other publications in which treatment was delayed until after delivery, or the pregnancy was terminated prior to beginning treatment. Our case highlights the importance of a multi-disciplinary approach to counseling patients in this unique situation to allow them the autonomy to choose the treatment best for them and their baby.

show abstract

Pregnancy-Associated Breast Cancer

Rouzier¹,

Bourdet-Trefoux²,

Genin³

et al. 2019

Breast Diseases

View full text Add to dashboard Cite

Breast cancer, along with cervical cancer, is one of the most commonly diagnosed cancers of pregnancy. Most would define gestational breast cancer as breast cancer that is diagnosed during pregnancy, lactation, and up to 12 months post-partum. The diagnostic and therapeutic implications in this clinical setting are special. These women typically present with a more advanced-stage disease that carries an associated poorer prognosis. Physicians thus are challenged to balance aggressive maternal care with appropriate modifications that will ensure fetal protection.

show abstract

Breast Cancer in Pregnancy

Cited by 23 publications

References 26 publications

Current management of pregnancy-associated breast cancer

Current management of pregnancy-associated breast cancer

Importance of a Multidisciplinary Approach to Breast Cancer Treatment in Pregnancy: Case Report of New Diagnosis of Pregnancy-Associated Breast Cancer

Pregnancy-Associated Breast Cancer

Contact Info

Product

Resources

About