Breast cancer in mothers prescribed diethylstilbestrol in pregnancy: Further follow-up

Colton, Theodore; Greenberg, E. Robert; Noller, Kenneth L.; Resseguie, Laurence J.; Bennekom, Carla Van; Heeren, Timothy; Zhang, Y.

doi:10.1016/0020-7292(94)90059-0

Cited by 11 publications

(14 citation statements)

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“…No clear relationship between adverse general health effects and exposure to endocrine modulators has been established, although involvement of EDs in human pathology has been suggested in numerous studies (95)(96)(97)(98)(99)(100)(101)(102). The influence of chemical compounds on allergic immune responses remains also unclear.…”

Section: Resultsmentioning

confidence: 99%

Endocrine disrupters – potential modulators of the immune system and allergic response

Chałubiński¹,

Kowalski²

2006

Allergy

150

103

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Endocrine disrupters (EDs) are environmental pollutants of industrial or agricultural origin (e.g. herbicides, fungicides, insecticides, industrial chemicals) that may influence health of wildlife and human. Endocrine‐disrupting effect is obtained by mimicking the action of the steroid hormones and has been associated with several reproductive disorders as well as cancerogenesis both in animals and humans. EDs can also influence synthesis of cytokines, immunoglobulins, and cell mediators as well as immune cell activation and survival. Modulation by EDs of interleukin‐4 production, Th1/Th2 balance and IgE production suggest their potential effect on allergic immune responses. The aim of this review was to summarize data indicating a potential effect of EDs exposure on the immune system and allergic responses.

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Section: Resultsmentioning

confidence: 99%

Endocrine disrupters – potential modulators of the immune system and allergic response

Chałubiński¹,

Kowalski²

2006

Allergy

150

103

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“…One of the clearest examples involves diethylstilbestrol (DES). While adult exposure to diethylstilbestrol (DES) modestly increases the risk of breast cancer and mortality from this disease later in life (RR = 1.27-1.35 for risk of disease and mortality with DES exposure) [19][20][21], fetal exposure to this agent apparently increases the incidence breast cancer in adult women much more dramatically (RR = 3.0 after the age of 50 yr) [22]. Similarly, clear cell adenocarcinomas of the vagina, a very rare cancer, has been observed in patients exposed prenatally to DES, but not after adult exposure [19;23;24].…”

Section: Assessment Of Bisphenol A-induced Carcinogenicity In Adult Rmentioning

confidence: 99%

An evaluation of evidence for the carcinogenic activity of bisphenol A

Keri

Hunt

et al. 2007

Reproductive Toxicology

259

153

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The National Institutes of Health (NIEHS, NIDCR) and the United States Environmental Protection Agency convened an expert panel of scientists with experience in the field of environmental endocrine disruptors, particularly with knowledge and research on Bisphenol A (BPA). Five subpanels were charged to review the published literature and previous reports in five specific areas and to compile a consensus report with recommendations. These were presented and discussed at an open forum entitled "Bisphenol

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“…Additional information will become available as more women with long-term oral contraceptive use reach the ages of higher breast cancer risk. Diethystilbestrol (DES), a potent synthetic estrogen, has been linked to increased breast cancer risk in women who took DES during pregnancy (Colton et al 1993;Titus-Ernstoff et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Environmental pollutants and breast cancer.

Brody

Rudel

2003

Environ Health Perspect

284

190

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Breast cancer is the most common cancer in women and the leading cause of cancer death among women 35-54 years of age. Rising incidence, increased risk among migrants to higher risk regions, and poor prediction of individual risk have prompted a search for additional modifiable factors. Risk factors for breast cancer include reproductive characteristics associated with estrogen and other hormones, pharmaceutical hormones, and activities such as alcohol use and lack of exercise that affect hormone levels. As a result, investigation of hormonally active compounds in commercial products and pollution is a priority. Compounds that cause mammary tumors in animals are additional priorities. Animal models provide insight into possible mechanisms for effects of environmental pollutants on breast cancer and identify chemical exposures to target in epidemiologic studies. Although few epidemiologic studies have been conducted for chemical exposures, occupational studies show associations between breast cancer and exposure to certain organic solvents and polycyclic aromatic hydrocarbons (PAHs). Population-based studies have been limited to a few organochlorine compounds and PAHs and have been mostly negative. A variety of challenges in studies of breast cancer and the environment may have contributed to negative findings. Lack of exposure assessment tools and few hypothesis-generating toxicologic studies limit the scope of epidemiologic studies. Issues of timing with respect to latency and periods of breast vulnerability, and individual differences in susceptibility pose other challenges. Substantial work is needed in exposure assessment, toxicology, and susceptibility before we can expect a pay-off from large epidemiologic studies of breast cancer and environment.

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Breast cancer in mothers prescribed diethylstilbestrol in pregnancy: Further follow-up

Cited by 11 publications

References 0 publications

Endocrine disrupters – potential modulators of the immune system and allergic response

Endocrine disrupters – potential modulators of the immune system and allergic response

An evaluation of evidence for the carcinogenic activity of bisphenol A

Environmental pollutants and breast cancer.

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