Breast Cancer in City of Kirkuk- Iraq; Focusing on Its Relationship to Some Other Clinic Pathologic Parameters and the Survival Rate

Abstract

Background: Breast cancer is the most common neoplasm in women, and it is the leading cause of cancer death in women. Major advances have been made in the diagnosis and treatment of breast cancer, resulting in a decrease in mortality from breast cancer over the last four decades. Objective: The aim of the current study is to compare the clinic-pathologic features and survival rate in the breast cancer subtypes in the city of Kirkuk -Iraq. Patients and methods: A retrospective study was conducted on the clinical-pathological data of 280 breast cancer female patients, with mean age of 50.05 year, who visited Kirkuk Oncology Center, over the period from April 2020 to January 2021. Results: Luminal A was the most commonly diagnosed subtype (57.0%) amongst them (56.9%) belonged to 41-50 years old age group. Significant association between menopause state and the relative survival rate (P =0.002) has been noticed. Nevertheless, a significant association between tumor stage AIII and postmenopausal patient was noticed (P =0.022), on the same time patients with tumor stage AIII showed a higher survival rate (≥5 years), whereas 85% of those who diagnosed with stage IV tumors survived for less than 5 years. Conclusion: Our results show the impact of molecular subtype, age, and tumor stage in breast cancer management. Efforts should be made to address the result of Luminal A breast cancer subtypes and to consider Her2 negative cases to produce a more reliable and reproducible diagnostic tool and treatment target, and to increase women's knowledge of breast cancer and the value of early diagnoses.