Breast cancer in association with thyroid disorders

Türken, Orhan; Narịn, Yavuz; Demirbaş, Sezai; M, Onde; Sayan, Özkan; Kandemir, Emin Gökhan; Yaylacı, Mustafa; Öztürk, Ahmet

doi:10.1186/bcr609

Cited by 133 publications

(152 citation statements)

References 27 publications

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“…However, the relationship between breast cancer and thyroid hormone is controversial. Even though many studies have shown that thyroid diseases are common in women with breast cancer, other reports have not confirmed this association (reviewed in 7,8). Almost every form of thyroid disease including hyperthyroidism has been identified in association with breast cancer (9-11).…”

Section: Introductionmentioning

confidence: 97%

Profile of thyroid hormones in breast cancer patients

Saraiva

Figueiredo

Padovani

et al. 2005

Braz J Med Biol Res

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Estrogen involvement in breast cancer has been established; however, the association between breast cancer and thyroid diseases is controversial. Estrogen-like effects of thyroid hormone on breast cancer cell growth in culture have been reported. The objective of the present study was to determine the profile of thyroid hormones in breast cancer patients. Serum aliquots from 26 patients with breast cancer ranging in age from 30 to 85 years and age-matched normal controls (N = 22) were analyzed for free triiodothyronine (T 3 F), free thyroxine (T 4 F), thyroid-stimulating hormone (TSH), antiperoxidase antibody (TPO), and estradiol (E 2 ). Estrogen receptor ß (ERß) was determined in tumor tissues by immunohistochemistry. Thyroid disease incidence was higher in patients than in controls (58 vs 18%, P < 0.05). Subclinical hyperthyroidism was the most frequent disorder in patients (31%); hypothyroidism (8%) and positive anti-TPO antibodies (19%) were also found. Subclinical hypothyroidism was the only dysfunction (18%) found in controls. Hyperthyroidism was associated with postmenopausal patients, as shown by significantly higher mean T 3 and T 4 values and lower TSH levels in this group of breast cancer patients than in controls. The majority of positive ERß tumors were clustered in the postmenopausal patients and all cases presenting subclinical hyperthyroidism in this subgroup concomitantly exhibited Erß-positive tumors. Subclinical hyperthyroidism was present in only one of 6 premenopausal patients. We show here that postmenopausal breast cancer patients have a significantly increased thyroid hormone/ E 2 ratio (P < 0.05), suggesting a possible tumor growth-promoting effect caused by this misbalance.

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Section: Introductionmentioning

confidence: 97%

Profile of thyroid hormones in breast cancer patients

Saraiva

Figueiredo

Padovani

et al. 2005

Braz J Med Biol Res

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“…Other factors, such as genetic mutations, environmental agents and immunomodulatory treatments, can also play roles (6). There are few authors who have directly indicated the increased risk of breast cancer in patients with autoimmune hypothyroidism and multiple sclerosis (18,19). Interestingly this case can be another example to study more about these associations.…”

Section: Discussionmentioning

confidence: 99%

Intracyctic Papillary Carcinoma of the Breast: Report of a Rare Case and Literature Review

et al. 2017

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Introduction: We present a rare case of breast papillary carcinoma associated with intracystic component in a woman with a long history of autoimmune hypothyroidism and multiple sclerosis. Case Presentation: The patient was a 59-year-old woman presented with complaints of pain and swelling in her right breast. She was a known case of autoimmune hypothyroidism since 20 years and secondary progressive multiple sclerosis since 13 years ago. She had received frequent interferon, corticosteroid and cytotoxic therapy for her multiple sclerosis. On imaging studies, there were multiple large cystic-solid lesions in the right breast and with presumptive diagnosis of infectious collection or phyllodes tumor, she finally underwent simple mastectomy. On gross pathological evaluation, a large multi-loculated cyst filled with blood clots and necrotic debris was identified. In serial sections, a 7 cm solid tumoral mass with papillary projections protruding into the cyst cavity was seen. Although the gross appearance of the lesion resembled an angiosarcoma accompanied by cystic hemorrhagic necrosis, after the microscopic evaluation of the specimen, papillary breast carcinoma associated with intracyctic component was finally diagnosed. Conclusions:The aim of this study was to describe a rare variant of invasive breast cancer presenting with a large solid-cyctic mass in a woman with long standing autoimmune disorders.

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“…Full--text ar+cles assessed for eligibility (n =21) Figure.1) (Turken et al, 2003;Cengiz et al, 2004;Kuijpens et al, 2005;Saraiva et al, 2005;Giustarini et al, 2006;Ditsch et al, 2010;Ali et al, 2011;Szychta et al, 2013) . Tables 1 and 2 show the characteristics and data of all 8 studies included in our analysis.…”

Section: Iden0fica0onmentioning

confidence: 99%

“…Thyroid diseases (TD) are frequently encountered in clinical practice and are more common among women (Vanderpump 2011). Breast cancer (BC) is a hormone-dependent neoplasm (Turken et al, 2003;Uyeturk et al, 2013). Various thyroid disorders have been detected in breast cancer patients (Smyth et al, 1996;Kuijpens et al, 2005;Ditsch et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Breast Cancer and Levels of Serum Thyroid Hormones and Antibodies: a Meta-analysis

Shi

Jin²,

Xu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The breast and the thyroid are hormone responsive organs that are closely related with changes of endocrine function and glandular disease. An association between thyroid disorders and breast cancer (BC) risk has been suggested, although the results are inconclusive. The purpose of the present study was to summarize evidence supporting a relationship between BC and the level of thyroid hormones and antibodies. The MEDLINE and EMBASE electronic databases were searched for studies published between 2000 and 2014. The pooled effects were presented as weighted mean differences (WMD) with 95% confidence intervals (CI) using fixed or random effect models. We summarized the results of 8 cross-sectional studies with 4, 189 participants. The overall pooled results showed that the levels of FT 3 and FT 4 were significantly increased in patients with BC (WMD=1.592 pmol/l; 95% CI: 0.15-3.033 and WMD=0.461 ng/dl; 95% CI: 0.015-0.906; p=0.043). The TPOAb level in patients with BC was higher than that in the control group (WMD=81.4 IU/ml; 95% CI: 78.7-84.0; p=0.000). The overall pooled results of the TgAb with random effects analyses showed that the TgAb level was significantly increased in patients with BC (WMD=101.3 IU/ml; 95% CI: 48.7-153.9; p=0.000). The present results indicated that the serum levels of FT 3 , TPOAb and TgAb are significantly higher in patients with breast cancer than in healthy controls.

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Breast cancer in association with thyroid disorders

Cited by 133 publications

References 27 publications

Profile of thyroid hormones in breast cancer patients

Profile of thyroid hormones in breast cancer patients

Intracyctic Papillary Carcinoma of the Breast: Report of a Rare Case and Literature Review

Relationship between Breast Cancer and Levels of Serum Thyroid Hormones and Antibodies: a Meta-analysis

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