Breast cancer in Arab populations: molecular characteristics and disease management implications

Chouchane, Lotfi; Boussen, H; Sastry, Konduru S.

doi:10.1016/s1470-2045(13)70165-7

Cited by 128 publications

(128 citation statements)

References 55 publications

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“…A similar difference in the average age of BC patients between Israeli-Arab women and Jewish patients has previously been reported in patients residing in the Jerusalem area (Nissan et al, 2004), and in northern Israel (Zidan et al, 2012). Several studies reported a similar pattern of earlier diagnosis of BC in Arab countries (Chouchane et al, 2013;Slaou et al, 2014). A younger age of BC patients has also been reported from many developing countries (Amaya-Ruiz et al, 2014;Keramtinia et al, 2014).…”

Section: Discussionsupporting

confidence: 70%

Breast Cancer in Bedouin-Arab Patients in Southern Israel: Epidemiologic and Biologic Features in Comparison with Jewish Patients

Lazarev

Flaschner²,

Geffen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Breast cancer (BC) is the most frequent cancer type and the leading cause of death among women in Israel (BaronApel, Israel Center for Disease Control) a. Time-trends in the incidence of BC have been different in Jewish and Israeli-Arab populations. Following a steady rise over a few decades, the incidence of BC in Jews decreased by 3% from 1996 through 2007. In contrast, the incidence of BC in Israeli-Arabs continued to increase by 98% over the same time-period. Age-adjusted incidence rates in Jews and Israeli-Arabs in 2010 reached levels of 91, and of 53 cases per 100,000 per year, respectively (Israel Cancer Registry, Jerusalem).Bedouin-Arabs (BA), who are part of the Israeli-Arab population of Israel, reside in the Negev, a desert and

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Section: Discussionsupporting

confidence: 70%

Breast Cancer in Bedouin-Arab Patients in Southern Israel: Epidemiologic and Biologic Features in Comparison with Jewish Patients

Lazarev

Flaschner²,

Geffen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The average age of occurrence of the BC in Tunisia reveals that the disease occurs a decade earlier, as compared with the Western countries (Chouchane et al, 2013). In the present study, mean age of cases was 50.9±11.9.…”

Section: Discussionsupporting

confidence: 43%

“…In the present study, mean age of cases was 50.9±11.9. By contrast, the average age of occurrence of BC among US white womens has been reported to be 61.0 years (Chouchane et al, 2013). The continuing rise of BC incidence has created an urgent need to develop strategies for its prevention.…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer in Tunisia: Association of Body Mass Index with Histopathological Aspects of Tumors

Bouguerra

Guissouma²,

Labidi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Previous studies have suggested a link between obesity and breast cancer (BC). However, there is no universal consensus, especially in population based studies. Because only few studies have been conducted on African women, we aimed here to assess the relationship between BMI at time of diagnosis and the BC histopathological features among Tunisian patients according to menopausal status using a hospital-based prospective cohort study. Materials and Methods: Clinical and pathological data were collected from 262 patients stratified on four groups according to their BMI. The relationship between BMI and histopathological features at diagnosis was analysed using univariate and multivariate analysis. Receiver-operating characteristic (ROC) curves were used to evaluate the performance of BMI in predicting of high tumor grade, in comparison to ki-67 index of proliferation. Results: Obesity was correlated with larger tumors, advanced grade and with ER-PRHer2+ BC subtype. An association of BMI with tumor size and tumor grade was observed in both premenopausal and postmenopausal women. Additionally, a significant association between BMI and ER+, ER+PR+Her2+ and ER-PR-Her2+ status was revealed for premenopausal patients, while only ER+PR+Her2+ was associated with BMI for postmenopausal women. Finally, our results showed that compared to Ki67 proliferation index, BMI is a useful prognostic marker of high grade BC tumors. Conclusions: These data are the first to show that in Tunisia obese women suffering from BC have significantly larger tumors and advanced tumor grade and that higher BMI might influence tumor characteristics and behavior.

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“…It implies that mammography should be performed in Arab populations prior to the younger average age at onset. 28 Although diagnosis of cancer is stressful at any stage in life, women at an early age encounter many challenges. Especially the patients in the younger age group have aggressive clinicopathologic features, and apart from the disease itself other issues like infertility, pregnancy, bone health, and psychosocial problems are simultaneous and affect their quality of life.…”

Section: Resultsmentioning

confidence: 99%

Female breast cancer in different age groups: clincopathological features and treatment strategies

Nuzhat

Abouzaid

2017

Int J Community Med Public Health

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INTRODUCTIONFemale breast cancer is a major public health problem throughout the world. It is the most common cancer type among women in developed and developing countries. Moreover, it is the principal cause of death from cancer among women globally. Nearly 55% of the worldwide burden is now experienced in developed countries, but incidence rates are rapidly rising in developing countries as well. 1According to the annual cancer incidence report published by the Saudi cancer registry, there were 1,853 female breast cancer cases for year 2013. Breast cancer ranked the first among females accounting for 29.1% of all newly diagnosed female cancers (6364) in year 2013. ABSTRACT Background:The proportion of breast cancer cases have been alarmingly increasing. In order to investigate the clinical and pathological features of breast cancer arising in all age groups and to provide evidence for therapy based on these features, we intended to conduct this study among three age groups, young (age ≤40), middle aged (>40-50) and elderly patients (>50). Methods: This cross-sectional study obtained data from the cancer center registry at King Fahad Medical City and included all women diagnosed as breast cancer between 1 st January 2011 till 31 st December 2012 and followed until December 2015 (n=155). Results: 25.2% patients were ≤40 years of age, 38.7% were >40-50 years and 36.1% were >50 years. The upper outer quadrant of the breast was most frequently area involved in all the three age groups. Majority of the cases were Invasive Ductal Carcinoma (IDC). 51.3% cases were of grade III in patients ≤40 years, 43.3% cases in the middle age group (>40-50 years) were of grade II and 44.6% patients were of grade III in the elderly group. More T3 tumours were noticed in the younger group and more T2 in the middle age group and greater lymph node involvement N2 in the age group >50 years. The mean survival time for patients' ≤40 was 37.6 months, 39.3 months for cases >40-50 years and 38.3 for patients >50 years old at the end of three years of follow up. At our cancer centre and among all the groups, majority of patients were treated with a combination of surgery, chemotherapy and radiation Conclusions: This study identifies cliniopathological features of breast cancer in all age groups in a tertiary care center, Saudi Arabia. Distant metastasis was more prevalent among younger age group and the middle aged women had the best mean survival time after three years.

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Breast cancer in Arab populations: molecular characteristics and disease management implications

Cited by 128 publications

References 55 publications

Breast Cancer in Bedouin-Arab Patients in Southern Israel: Epidemiologic and Biologic Features in Comparison with Jewish Patients

Breast Cancer in Bedouin-Arab Patients in Southern Israel: Epidemiologic and Biologic Features in Comparison with Jewish Patients

Breast Cancer in Tunisia: Association of Body Mass Index with Histopathological Aspects of Tumors

Female breast cancer in different age groups: clincopathological features and treatment strategies

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