Breast Cancer in Adolescents and Young Adults Less Than 40 Years of Age in Nigeria: A Retrospective Analysis

Ntekim, Atara; Oluwasanu, Mojisola; Odukoya, Oluwaponmile

doi:10.1155/2022/9943247

Cited by 12 publications

(14 citation statements)

References 25 publications

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“…This study showed that breast cancer occurs primarily in the young and middle-aged groups in this environment. This is similar to the findings of other studies in Nigeria which showed that breast cancer occurs at a younger age compared to Caucasians [4,[24][25][26].…”

Section: Discussionsupporting

confidence: 92%

Evaluation of side effects and compliance to chemotherapy in breast cancer patients at a Nigerian tertiary hospital

Folorunso¹,

Abiodun²,

Abdus-salam³

et al. 2023

ecancer

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Background: Chemotherapy improves tumour control and survival, but it may be associated with side effects (SEs) which can impair treatment compliance and worsen outcomes. Assessment of patients in routine clinical practice, outside clinical trials, may provide the information on effects of chemotherapy on patients and its impacts on treatment compliance.Aim: To assess the SE and compliance to chemotherapy in breast cancer patients.Methodology: A prospective study involving 120 breast cancer patients receiving chemotherapy was carried out at the oncology clinics of the University College Hospital Ibadan. SEs reported were recorded and graded using Common Toxicity Criteria for Adverse Events version 5. Compliance was defined as a receipt of planned cycles of chemotherapy in the planned doses within the planned duration. The data collected were analysed using the Statistical Package for the Social Sciences software version 25. Results:The patients were all females with a mean age of 51.2 ± 11.8 years. Patients reported between 2 and 13 SE with a median of 8 SE. Forty-two (35.0%) missed at least one course of chemotherapy while 78 (65%) were compliant. The reasons for non-compliance were deranged blood test 17 (14.2%), chemotherapy SE symptoms related 11 (9.1%), financial constraints 10 (8.3%), disease progression 2 (1.7%) and transportationrelated 2 (1.7%). Conclusion:Breast cancer patients encounter multiple SEs from chemotherapy which led to non-compliance with the treatment. Early identification and prompt treatment of these SEs will improve compliance with chemotherapy.

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Section: Discussionsupporting

confidence: 92%

Evaluation of side effects and compliance to chemotherapy in breast cancer patients at a Nigerian tertiary hospital

Folorunso¹,

Abiodun²,

Abdus-salam³

et al. 2023

ecancer

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“…A recent retrospective study in Nigeria among adolescents and young adult females aged 15 to 39 years showed that breast cancer was the most common cancer, accounting for 50% of all cancers. The adolescents and young adult females breast cancer patients constituted 51% of all breast cancer cases 5,6 . Similar findings are made in Togo, where breast cancer ranks first in female cancers, accounting for 21.2%, and strucks 38.3% of women under the age of 40 7 .…”

Section: Introductionmentioning

confidence: 99%

Integrating network pharmacology and pharmacological evaluation to investigate the anticancer effects of Duranta erecta Linn. Verbenaceae in breast cancer

Agbana¹,

Abu²,

Akinleye³

et al. 2023

Preprint

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Objective Breast cancer is the most prevalent type of cancer among women in sub-Saharan Africa. Efforts are being made to tackle the disease. However, numerous challenges are still reported. Duranta erecta showed medicinal relevance in different ailments but its molecular mechanism of action in breast cancer is not unraveled. The objective of this study is to evaluate the anticancer effect of Duranta erecta on breast cancer cells and determine the molecular mechanism of action in silico. Materials and Methods The Phytochemical Interaction Database, published literature, and the Swiss TargetPrediction database, respectively, were used to identify the active ingredients and targets of Duranta erecta. GEO datasets and TCGA databases were searched for breast cancer-related targets. A protein-protein interaction (PPI) network was constructed to screen the primary targets. For GO and KEGG pathway enrichment analyses, ShinyGO was used. By using molecular docking, interactions between potential targets and active substances were evaluated. MTT assay was conducted to evaluate the cytotoxicity effect of Duranta erecta. Results Duranta erecta demonstrated a cytotoxic effect on breast cancer cells. The IC50 values are 9.99 µg/mL and 15.07 µg/mL for the fruit extract and the leaves extract respectively. A total of 102 common targets and 77 active plant compounds were discovered, of which 37 are potential drug candidates. There were 10 hub targets identified by the PPI network. The hub targets are linked to pathways in cell proliferation and cancer. The best overall binding affinity was demonstrated by repenin A in binding with AURKA, CDK1, and EGFR. Conclusion This study was able to accurately predict the active ingredients and potential targets used in Duranta erecta's treatment of breast cancer. This study offers a fresh approach to future deeper studies on the molecular mechanisms of the plant and its compounds in breast cancer.

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“…There are considerable epidemiological and biological variations between blacks and whites with breast cancer, which has far-reaching consequences for the establishment of an efficient cancer screening program in Nigeria. Ntekim et al [12], did a study with the goal of describing the clinicopathologic aspects of breast cancer identified at their hospital and discussing the implications for cancer screening. They conclude that there are major epidemiological and biological differences between breast cancer in Lagos and in western populations that must be addressed in order to build an effective breast cancer screening program that is specifically adapted to the Nigerian population.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Some Selected Breast Cancer Classification Algorithms in Nigeria

Suleiman

Eviwiekpaefe

Yakubu³

et al. 2022

J Biochem Microbiol Biotechnol

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Breast Cancer (BC) is a prevalent disease that affects mostly women in the world. According to the World Health Organization (WHO), BC represent about 25 percent of all cancers in women with 685 000 deaths in 2020. An early detection of this disease can greatly increase the chances of taking the right decision on a successful treatment plan. This resulted in the need of new research avenues most especially in a country like Nigeria where there is low awareness of the disease and late presentation of BC by patients is normal. To achieve this, Support Vector Machine (SVM), KN Neighbor (KNN) and Decision Tree (DT) was used on a local dataset obtained from Ahmadu Bello University Teaching Hospital Zaria to provide some effective diagnostic capabilities. The dataset was classified into three classes (Benign, Pre-malign and Malign) and the SVM obtained a good classification accuracy of (99.2%). Late presentation of breast cancer is normal because of low awareness of the disease in the country therefore more awareness of the disease is highly recommended and women above the age of 34 years should always go for the breast cancer screening at least once a year with or without sign, sickness or symptoms.

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Breast Cancer in Adolescents and Young Adults Less Than 40 Years of Age in Nigeria: A Retrospective Analysis

Cited by 12 publications

References 25 publications

Evaluation of side effects and compliance to chemotherapy in breast cancer patients at a Nigerian tertiary hospital

Evaluation of side effects and compliance to chemotherapy in breast cancer patients at a Nigerian tertiary hospital

Integrating network pharmacology and pharmacological evaluation to investigate the anticancer effects of Duranta erecta Linn. Verbenaceae in breast cancer

Evaluation of Some Selected Breast Cancer Classification Algorithms in Nigeria

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