Breast Cancer: Factors Associated With Stage at Diagnosis in Black and White Women

Hunter, Carrie P.; Redmond, Carol; Chen, Vivien W.; Austin, Donald F.; Greenberg, Raymond S.; Correa, Pelayo; Muss, Hyman B.; Forman, Michéle R.; Wesley, Margaret N.; Blacklow, Robert S.; Kurman, Robert J.; Dignam, James J.; Edwards, Brenda K.; Shapiro, Sam

doi:10.1093/jnci/85.14.1129

Cited by 178 publications

(118 citation statements)

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“…20,21 In the present study breast cancer onset was 5 years earlier in black patients than in whites. This difference cannot be easily explained by socioeconomic status, which affects the rates of mammography for early breast cancer screening.…”

Section: Discussionsupporting

confidence: 43%

Mutations in the p53 Tumor Suppressor Gene and Early Onset Breast Cancer

Li¹,

Lin²,

Nadji³

et al. 2002

Cancer Biology & Therapy

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© 2 0 0 2 L a n d e s B i o s c i e n c e . N o t f o r d i s t r i b u t i o n .[Cancer Biology & Therapy 1, 31-36, January 2002]; published online as a CB&T "Papers In Press" at www. Research ArticleMutations in the p53 Tumor Suppressor Gene and Early Onset Breast Cancer ABSTRACTAmong breast cancer patients p53 gene mutation is associated with a poor prognosis. Young women with breast cancer are more likely than older women to have a poor prognosis, but whether p53 gene mutation plays a role in breast cancer in young women is not clear. This study identified 199 breast cancer patients and tested the hypothesis that p53 gene mutation was associated with early onset breast cancer. Patients with p53 gene mutations were 3-times more likely to have an early onset breast cancer (age ≤ 40 years at diagnosis) than those without p53 mutations (OR=3.05, 95% CI=1.10-8.45). Patients with both missense and silent mutations were 7-times more likely to have a diagnosis of early onset breast cancer (OR=7.56, 95% CI=2.22-25.8). Patients with mutations in exon 8 of the p53 gene were 6-times more likely to be diagnosed with early onset breast cancer (OR=6.48, 95% CI=1.37-30.6). These findings suggest that p53 gene mutation may hasten the onset of female breast cancer.

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Section: Discussionsupporting

confidence: 43%

Mutations in the p53 Tumor Suppressor Gene and Early Onset Breast Cancer

Li¹,

Lin²,

Nadji³

et al. 2002

Cancer Biology & Therapy

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“…105,106 In studies that included large numbers of African American women, obesity has also been shown to be associated with larger tumors, positive lymph nodes, and later stage at diagnosis. 30,98,107 Of relevance to this discussion, Jones et al showed that, in multivariate analyses, 30% of the later stage at diagnosis observed in African American women relative to white women could be attributed to the greater prevalence of severe obesity in this population. 98 Results from a recent analysis of data from the Carolina Breast Cancer Study basically confirmed these findings.…”

Section: Obesitymentioning

confidence: 99%

“…Results from the first study of this type, the National Cancer Institute's (NCI) Black/White Cancer Survival Study, also indicated that mammography screening history played a negligible explanatory role, once other variables were introduced into the model. 30 Trends in late-stage diagnosis indicate a narrowing of the black-white gap in the proportions of women diagnosed with regional and distant stage breast cancers from 1988 to 1995 (Surveillance, Epidemiology and End Results [SEER] data). 31 Trends in breast cancer mortality show a decrease among white women aged 40-79 years from 1989 to 1992.…”

Section: Observational Datamentioning

confidence: 99%

Mammography screening in African American women

Jones

Patterson²,

Calvocoressi

2002

Cancer

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“…Although several studies reported an association between increasing body mass index and advanced stage (Ingram et al, 1989;Hunter et al, 1993;Reeves et al, 1996) it is not clear why obese women seem to wait longer to present their breast cancer symptoms to a doctor. The results from our multivariable analyses indicate that the association between body mass index and patient delay is not explained by differences in health behaviour (as measured in our study), social class or education.…”

Section: Clinicalmentioning

confidence: 99%

Patient delay and stage of diagnosis among breast cancer patients in Germany – a population based study

et al. 2002

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Early diagnosis is a tenet in oncology and should enable early treatment with the expectation of improved outcome. Extent and determinants of patient delay of diagnosis in breast cancer patients and its impact on stage of disease were examined in a population based study among female breast cancer patients in Germany. Two hundred and eighty-seven women, aged 18 to 80 years with newly diagnosed invasive symptomatic breast cancer, were interviewed with respect to the diagnostic process. Patient delay was defined as time from onset of first symptoms to first consultation of a doctor. Median patient delay was 16 days among symptomatic patients. Eighteen per cent of all breast cancer patients waited longer than 3 months before consulting a physician. Long patient delay was associated with old age, history of a benign mastopathy, obesity, and indices of health behaviour such as not knowing a gynaecologist for out-patient care and non-participation in general health screening examinations. A strong association between patient delay and stage at diagnosis was observed for poorly differentiated tumours. These results suggest that at risk groups for delaying consultation can be identified and that a substantial proportion of late stage diagnoses of poorly differentiated breast cancer cases could be avoided if all patients with breast cancer symptoms would present to a doctor within 1 month.

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Breast Cancer: Factors Associated With Stage at Diagnosis in Black and White Women

Abstract: These findings suggest that no single factor or group of factors can explain more than half of the race-stage differences noted in this study with respect to Black and White breast cancer patients.

Cited by 178 publications

References 0 publications

Mutations in the p53 Tumor Suppressor Gene and Early Onset Breast Cancer

Mutations in the p53 Tumor Suppressor Gene and Early Onset Breast Cancer

Mammography screening in African American women

Patient delay and stage of diagnosis among breast cancer patients in Germany – a population based study

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