Breast Cancer Epidemiology in Gulf Cooperation Council Countries: A Regional and International Comparison

Albeshan, Salman M.; Mackey, Martin; Hossain, Syeda Zakia; Alfuraih, A.; Brennan, Patrick C.

doi:10.1016/j.clbc.2017.07.006

Cited by 45 publications

(40 citation statements)

References 106 publications

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“…In the Middle East, 25% of all reported cases of female cancer in 2012, were breast cancers. It has been projected that by 2020 about 2 million women will be diagnosed with breast cancer worldwide, a disturb increase of approximately 18.4% [3,10]. Moreover, about 30% of Middle Eastern patients with newly diagnosed early stage breast cancer will go on to develop metastasis despite extensive therapy [6].…”

Section: Challenges In Breast Cancer Diagnosis and Treatmentmentioning

confidence: 99%

Gene Silencing Agents in Breast Cancer

Qattan¹

2019

Modulating Gene Expression - Abridging the RNAi and CRISPR-Cas9 Technologies

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MicroRNAs (miRs) are a class of non-coding RNAs, approximately 20-25 nucleotides long, discovered in the nematode, Caenorhabditis elegans, in 1993. There are two primary categories of non-coding RNA (ncRNA): (1) short interfering RNAs (siRNA) and (2) microRNAs (miRs). In general, miRs control protein production via partially complementary binding of the mRNA 3′UTRs. Both siRNAs and miRNAs are critical regulators of developmental and homeostatic processes as well as disease pathogenesis. While the treatment of advanced stage breast cancer presents several challenges, the development of therapeutic resistance contributes to a high mortality rate. Dysregulation of miR expression has been implicated in progression of breast cancer disease. Moreover, miRs have been found to play a role in the development of drug resistance. In this context, one of the therapeutic potentials of miRNAs is the correlation of circulating miR levels with breast cancer progression stages and disease phenotypes. Secondly, researchers are investigating novel delivery strategies for the substitution or silencing of ncRNAs involved in the disease. This chapter describes both the general miRNA mechanism of actions and the miRNAs related to breast cancer research. It is specifically designed for breast cancer researchers with expertise in gene delivery, clinicians, and clinical translational scientists.

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Section: Challenges In Breast Cancer Diagnosis and Treatmentmentioning

confidence: 99%

Gene Silencing Agents in Breast Cancer

Qattan¹

2019

Modulating Gene Expression - Abridging the RNAi and CRISPR-Cas9 Technologies

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“…Since breast cancer is the most commonly diagnosed female cancer in Australia and Japan, population-based breast cancer screening is conducted nationally in both countries (Australian Institute of Health and Welfare, 2012; National cancer centre Japan, 2014). Comparison of breast cancer incidence (BCI) rates in Australia and Japan shows that the BCI peaks in Australia for women aged 65-69 years and in Japan for women aged 45-49 (Matsuda et al, 2010;Albeshan et al, 2018b). Therefore,…”

Section: Introductionmentioning

confidence: 99%

Mammographic Breast Density of Japanese Women Living in Australia: Implications for Breast Screening Policy

Mizukoshi

Hossain

Poulos

2019

Asian Pac J Cancer Prev

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Breastscreen Australia targets women aged 50-74 for screening mammography and the Japanese Breast Cancer Society targets women aged 40-74 (Japanese Breast Cancer Society, 2015; Australian Government, 2016). Previous BCI studies in multi-ethnic countries have reported that BCI rates vary between ethnicities, and BCI rates among migrants did not exhibit the same characteristics of either their country of origin or their host country (Maskarinec and Noh, 2004; Albeshan et al., 2018b). Women of Asian descent living in North America have a markedly increased BCI rate (Health Quality Ontario, 2007), and the BCI rates for Japanese American women have also demonstrated a rapid increase.

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“…[ 3 ] In 2012, the incidence of breast cancer in Saudi Arabia had increased by >30% from 2008. [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

“…Early age and an advanced stage at diagnosis are significant problems with breast cancer in Saudi Arabia. [ 4 5 6 ] In the last two decades, advances in breast cancer diagnostic and treatment modalities have resulted in a reduction in mortality and improved survival rates. Breast cancer survivors frequently present with emotional or physical long-term impairment, caused either by the disease or treatment, which compromises their quality of life (QOL).…”

Section: Introductionmentioning

confidence: 99%