Breast Cancer: Early- and Late-Fluorescence Near-Infrared Imaging with Indocyanine Green—A Preliminary Study

Poellinger, Alexander; Burock, Susen; Grosenick, Dirk; Hagen, Axel; Lüdemann, Lutz; Diekmann, Felix; Engelken, F.; Macdonald, Rainer; Rinneberg, H.; Schlag, P.M.

doi:10.1148/radiol.10100258

Cited by 83 publications

(70 citation statements)

References 20 publications

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“…Only a few investigators have used extrinsic contrast with mostly reporting measurements of ICG (indocyanine green) absorption [48][49][50][51][52][53]. ICG fluorescence has only been investigated in two studies [54,55], while three publications on omocianine fluorescence are available at the time of writing [56][57][58].…”

Section: Biophotonicsmentioning

confidence: 99%

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Near‐infrared imaging of breast cancer using optical contrast agents

Poellinger

2012

Journal of Biophotonics

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Breast cancer is the most common malignancy in women worldwide and the second leading cause of cancer death. On the basis of three studies performed by our group, this article reviews the current status of optical breast imaging using extrinsic contrast agents. To date, only two contrast agents have been applied in human studies, indocyanine green (ICG) and omocianine. Both contrast media were used for absorption and fluorescence imaging. Generally speaking, malignant breast lesions exhibited higher absorption contrast as well as higher fluorescence contrast compared to benign lesions or non‐diseased breast tissue. Some groups consider early enhancement characteristics helpful for differentiation between malignant and benign lesions. Late fluorescence ICG imaging – capitalizing on the extravasation of the dye through the wall of tumorous vessels – seems to be a promising technique to distinguish malignant from benign breast lesions. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Section: Biophotonicsmentioning

confidence: 99%

“…Using a time-resolved technique we investigated early and late fluorescence of breast lesions [50,55]. The system uses a slab-design with the breast being slightly compressed between two parallel glass plates.…”

Section: Indocyanine Green As a Fluorescence Contrast Agentmentioning

confidence: 99%

Near‐infrared imaging of breast cancer using optical contrast agents

Poellinger

2012

Journal of Biophotonics

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“…NIR imaging has various applications like optical tomography [1][2], diagnosis of brain edema [3][4] and also mammography [5][6]. IR wavelength range starts from 750nm and extends up to 1mm, covering almost three orders of magnitude in the overall electromagnetic spectrum.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Infra-Red Images of Human Hand

Pillai¹,

Mil’shtein²

2012

AJBE

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Among the various technologies used for medical imaging, Infra-Red methods occupies very important place, as IR light interaction with human body became to be a base for thermography, tomography and visualization of blood vessels. Different types of medical imaging techniques exists which are classified on the basis of the wavelength of the radiation used, the mode of operation (transmission or reflection) and the reproduction of the acquired information in the form of images. The human hand is one of the most complicated mechanical -biological objects. The complexity of various bones and tendons, joints and muscles, various soft tissues and network of blood vessels presents a significant challenge to any visualization technique. The request of medical professionals for clarity of hand images requires elimination of some parts of the image, colorizing, and contrast enhancement. In this study, we report significant improvement of IR images of the hand. Enhanced IR images allow clear visualization of tendons which are otherwise seen only by MRI.

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“…Widely accepted advantages of optical imaging include the absence of radiation exposure and its relatively low cost [20] based on the relatively low investment cost of the components required to perform optical imaging. Some studies use an extrinsic contrast agent such as ICG or Omocianine as a dye to enhance contrasts in optical imaging [6,29]. The possible advantages of using extrinsic contrast make optical imaging more complex and may represent a disadvantage for its use as a screening tool, which should be very easy to handle.…”

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confidence: 99%

“…The false-positive rate for benign lesions was 11.8 %. In another study using ICG, Poellinger et al analyzed optical mammography in the fluorescence mode and achieved a mean sensitivity of 92 % and a mean specificity of 75 % [29]. A considerable drawback of using the Valsalva maneuver is that there is very wide interindividual variation in how it is performed.…”

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confidence: 99%

Optical Imaging of Breast Cancer Using Hemodynamic Changes Induced by Valsalva Maneuver

Schreiter

Volkwein

Schneider

et al. 2013

Fortschr Röntgenstr

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Purpose: To investigate whether changes in hemodynamics induced by Valsalva maneuver can be exploited for detecting and characterizing breast lesions by optical mammography. Materials and Methods: 30 women underwent optical imaging of the breast using a DYNOT 232 system and performing Valsalva maneuvers prior to biopsy. Changes in light absorption due to changes in oxyhemoglobin and deoxyhemoglobin concentrations were recorded volumetrically and in a time-resolved manner. The parameters full width at half maximum (FWHM), time to ten (TTT), and peak amplitude (PA) of the reconstructed concentration time curves yielded color-coded maps of the breast which were separately evaluated by two experienced readers for detection rate, degree of visibility, and detection of additional lesions. ROC analysis was performed with the evaluation results. Results: 10 patients were excluded from analysis due to artifacts or inadequately performed Valsalva maneuver. The resulting 20 patients showed a clear increase in oxygenated and deoxygenated hemoglobin concentration after the onset of the Valsalva maneuver. ROC analysis yielded AUC values (0.393???0.779) that did not differ from random probabilities. The highest AUC values were obtained for FWHM (AUC: 0.779, detection rates [60???70?%], identification of additional lesions [55???70?%]). PA analysis had the highest detection rate (70???90?%) but also the highest identification of false-positive additional lesions (80???90?%). The concordance rates of the two readers for malignant lesions were satisfactory (0.524???1.0). Conclusion: Our study revealed susceptibility to artifacts and a large number of false-positive additional lesions, suggesting that the evaluation of hemodynamic changes after Valsalva maneuver by optical imaging is not a promising method.

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Breast Cancer: Early- and Late-Fluorescence Near-Infrared Imaging with Indocyanine Green—A Preliminary Study

Abstract: Preliminary data suggest that early- and late-fluorescence ratio imaging after ICG administration can be used to distinguish malignant from benign breast lesions.

Cited by 83 publications

References 20 publications

Near‐infrared imaging of breast cancer using optical contrast agents

Near‐infrared imaging of breast cancer using optical contrast agents

Enhancement of Infra-Red Images of Human Hand

Optical Imaging of Breast Cancer Using Hemodynamic Changes Induced by Valsalva Maneuver

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