Breast Cancer Diagnosis Using an Efficient CAD System Based on Multiple Classifiers

Ragab, Dina A.; Sharkas, Maha; Attallah, Omneya

doi:10.3390/diagnostics9040165

Cited by 52 publications

(40 citation statements)

References 40 publications

(58 reference statements)

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“…CADx could assist pathologists in the automatic analysis of histopathological images, thus decreasing the cost of diagnosis [ 22 ]. Several CADx systems have been proposed to solve related medical problems [ 23 , 24 , 25 , 26 , 27 ]. However, less work has been made to classify the childhood MB and its subtypes from histopathological images using ML and DL techniques, due to the lack of data availability.…”

Section: Introductionmentioning

confidence: 99%

MB-AI-His: Histopathological Diagnosis of Pediatric Medulloblastoma and its Subtypes via AI

Attallah

2021

Diagnostics

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Medulloblastoma (MB) is a dangerous malignant pediatric brain tumor that could lead to death. It is considered the most common pediatric cancerous brain tumor. Precise and timely diagnosis of pediatric MB and its four subtypes (defined by the World Health Organization (WHO)) is essential to decide the appropriate follow-up plan and suitable treatments to prevent its progression and reduce mortality rates. Histopathology is the gold standard modality for the diagnosis of MB and its subtypes, but manual diagnosis via a pathologist is very complicated, needs excessive time, and is subjective to the pathologists’ expertise and skills, which may lead to variability in the diagnosis or misdiagnosis. The main purpose of the paper is to propose a time-efficient and reliable computer-aided diagnosis (CADx), namely MB-AI-His, for the automatic diagnosis of pediatric MB and its subtypes from histopathological images. The main challenge in this work is the lack of datasets available for the diagnosis of pediatric MB and its four subtypes and the limited related work. Related studies are based on either textural analysis or deep learning (DL) feature extraction methods. These studies used individual features to perform the classification task. However, MB-AI-His combines the benefits of DL techniques and textural analysis feature extraction methods through a cascaded manner. First, it uses three DL convolutional neural networks (CNNs), including DenseNet-201, MobileNet, and ResNet-50 CNNs to extract spatial DL features. Next, it extracts time-frequency features from the spatial DL features based on the discrete wavelet transform (DWT), which is a textural analysis method. Finally, MB-AI-His fuses the three spatial-time-frequency features generated from the three CNNs and DWT using the discrete cosine transform (DCT) and principal component analysis (PCA) to produce a time-efficient CADx system. MB-AI-His merges the privileges of different CNN architectures. MB-AI-His has a binary classification level for classifying among normal and abnormal MB images, and a multi-classification level to classify among the four subtypes of MB. The results of MB-AI-His show that it is accurate and reliable for both the binary and multi-class classification levels. It is also a time-efficient system as both the PCA and DCT methods have efficiently reduced the training execution time. The performance of MB-AI-His is compared with related CADx systems, and the comparison verified the powerfulness of MB-AI-His and its outperforming results. Therefore, it can support pathologists in the accurate and reliable diagnosis of MB and its subtypes from histopathological images. It can also reduce the time and cost of the diagnosis procedure which will correspondingly lead to lower death rates.

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Section: Introductionmentioning

confidence: 99%

MB-AI-His: Histopathological Diagnosis of Pediatric Medulloblastoma and its Subtypes via AI

Attallah

2021

Diagnostics

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“…Moreover, these CAD systems have the potential to deliver an accurate and fast second opinion, to help radiologists in giving an accurate diagnosis based on medical images ( Ardakani et al, 2020 ). Furthermore, a CAD system can avoid diagnostic errors caused by human which might occur due to the exertion done during clinical examinations and radiologists’ visual fatigue ( Ragab, Sharkas & Attallah, 2019 ; Ragab et al, 2019 ). This can assist in managing the current pandemic, speed up the detection of the disease, avoid its fast spread, and help doctors to improve the quality of patient management, even in extraordinary workload situations.…”

Section: Introductionmentioning

confidence: 99%

MULTI-DEEP: A novel CAD system for coronavirus (COVID-19) diagnosis from CT images using multiple convolution neural networks

Attallah¹,

Ragab²,

Sharkas³

2020

PeerJ

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Coronavirus (COVID-19) was first observed in Wuhan, China, and quickly propagated worldwide. It is considered the supreme crisis of the present era and one of the most crucial hazards threatening worldwide health. Therefore, the early detection of COVID-19 is essential. The common way to detect COVID-19 is the reverse transcription-polymerase chain reaction (RT-PCR) test, although it has several drawbacks. Computed tomography (CT) scans can enable the early detection of suspected patients, however, the overlap between patterns of COVID-19 and other types of pneumonia makes it difficult for radiologists to diagnose COVID-19 accurately. On the other hand, deep learning (DL) techniques and especially the convolutional neural network (CNN) can classify COVID-19 and non-COVID-19 cases. In addition, DL techniques that use CT images can deliver an accurate diagnosis faster than the RT-PCR test, which consequently saves time for disease control and provides an efficient computer-aided diagnosis (CAD) system. The shortage of publicly available datasets of CT images, makes the CAD system’s design a challenging task. The CAD systems in the literature are based on either individual CNN or two-fused CNNs; one used for segmentation and the other for classification and diagnosis. In this article, a novel CAD system is proposed for diagnosing COVID-19 based on the fusion of multiple CNNs. First, an end-to-end classification is performed. Afterward, the deep features are extracted from each network individually and classified using a support vector machine (SVM) classifier. Next, principal component analysis is applied to each deep feature set, extracted from each network. Such feature sets are then used to train an SVM classifier individually. Afterward, a selected number of principal components from each deep feature set are fused and compared with the fusion of the deep features extracted from each CNN. The results show that the proposed system is effective and capable of detecting COVID-19 and distinguishing it from non-COVID-19 cases with an accuracy of 94.7%, AUC of 0.98 (98%), sensitivity 95.6%, and specificity of 93.7%. Moreover, the results show that the system is efficient, as fusing a selected number of principal components has reduced the computational cost of the final model by almost 32%.

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“…The novel virus known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged in December 2019 in Wuhan, China. Patients diseased with SARS-CoV-2 can experience a medical condition known as coronavirus diseases 2019 diseases and abnormalities from medical images (Ragab, Sharkas & Attallah, 2019;Attallah, Sharkas & Gadelkarim, 2019;Attallah, Sharkas & Gadelkarim, 2020;Attallah, Gadelkarim & Sharkas, 2018). The CAD systems were used to diagnose several lung diseases such as tuberculosis (Ke et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

FUSI-CAD: Coronavirus (COVID-19) diagnosis based on the fusion of CNNs and handcrafted features

Ragab¹,

Attallah²

2020

PeerJ Computer Science

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The precise and rapid diagnosis of coronavirus (COVID-19) at the very primary stage helps doctors to manage patients in high workload conditions. In addition, it prevents the spread of this pandemic virus. Computer-aided diagnosis (CAD) based on artificial intelligence (AI) techniques can be used to distinguish between COVID-19 and non-COVID-19 from the computed tomography (CT) imaging. Furthermore, the CAD systems are capable of delivering an accurate faster COVID-19 diagnosis, which consequently saves time for the disease control and provides an efficient diagnosis compared to laboratory tests. In this study, a novel CAD system called FUSI-CAD based on AI techniques is proposed. Almost all the methods in the literature are based on individual convolutional neural networks (CNN). Consequently, the FUSI-CAD system is based on the fusion of multiple different CNN architectures with three handcrafted features including statistical features and textural analysis features such as discrete wavelet transform (DWT), and the grey level co-occurrence matrix (GLCM) which were not previously utilized in coronavirus diagnosis. The SARS-CoV-2 CT-scan dataset is used to test the performance of the proposed FUSI-CAD. The results show that the proposed system could accurately differentiate between COVID-19 and non-COVID-19 images, as the accuracy achieved is 99%. Additionally, the system proved to be reliable as well. This is because the sensitivity, specificity, and precision attained to 99%. In addition, the diagnostics odds ratio (DOR) is ≥ 100. Furthermore, the results are compared with recent related studies based on the same dataset. The comparison verifies the competence of the proposed FUSI-CAD over the other related CAD systems. Thus, the novel FUSI-CAD system can be employed in real diagnostic scenarios for achieving accurate testing for COVID-19 and avoiding human misdiagnosis that might exist due to human fatigue. It can also reduce the time and exertion made by the radiologists during the examination process.

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Breast Cancer Diagnosis Using an Efficient CAD System Based on Multiple Classifiers

Cited by 52 publications

References 40 publications

MB-AI-His: Histopathological Diagnosis of Pediatric Medulloblastoma and its Subtypes via AI

MB-AI-His: Histopathological Diagnosis of Pediatric Medulloblastoma and its Subtypes via AI

MULTI-DEEP: A novel CAD system for coronavirus (COVID-19) diagnosis from CT images using multiple convolution neural networks

FUSI-CAD: Coronavirus (COVID-19) diagnosis based on the fusion of CNNs and handcrafted features

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