Breast Cancer Diagnosis in Coronavirus-Era: Alert From Italy

Vanni, Gianluca; Pellicciaro, Marco; Materazzo, Marco; Palombi, Leonardo; Buonomo, Oreste Claudio

doi:10.3389/fonc.2020.00938

Cited by 39 publications

(50 citation statements)

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“…Today, having no reliable data regarding the end of the epidemic, the idea of postponing all treatments until the end of the outbreak is not feasible for cancer patients. Therefore, several guidelines have been published in order reduce the detrimental effect of COVID-19 outbreak (2,7,8,(31)(32)(33). Triage of urgent clinical cases, awake and fast track surgery could increase the number of treated patients, reducing hospitalizations as well as the risk of cross-infection during the COVID-19 era (8,(34)(35)(36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

“…Triage of urgent clinical cases, awake and fast track surgery could increase the number of treated patients, reducing hospitalizations as well as the risk of cross-infection during the COVID-19 era (8,(34)(35)(36)(37)(38). Breast oncological treatment was only partially impaired by the COVID-19 outbreak and breast specialists try to provide the best cancer treatment for a higher number of patients (2,7,8,35,39). Hence, breast cancer specialists could provide a good model for understanding how the COVID-19 outbreak could influence health well-being among the low risk HCWs population.…”

Section: Discussionmentioning

confidence: 99%

“…increasing numbers of health care workers (HCWs) have been facing a new highly contagious infectious disease (5). In spite of having a separate route and applying infection control (IC) measures during this period, patients could refuse surgery or diagnostic procedures due to COVID-19 infection risk, reducing the number of admitted patients in the hospital (2,(6)(7)(8). Moreover, IC measures include instructions to HCWs to maintain a physical distance from other colleagues, patients and families which could eventually lead to psychological distress (9)(10)(11).…”

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confidence: 99%

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The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey

Vanni

Materazzo

Santori

et al. 2020

In Vivo

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Background/Aim: Despite the large amount of clinical data available of Coronavirus-19 (COVID-19), not many studies have been conducted about the psychological toll on Health Care Workers (HCWs). Patients and Methods: In this multicentric descriptive study, surveys were distributed among 4 different Breast Cancer Centers (BCC). BCCs were distinguished according to COVID-19 tertiary care hospital (COVID/No-COVID) and district prevalence (DP) (High vs. Low). DASS-21 score, PSS score and demographic data (age, sex, work) were evaluated. Results: A total of 51 HCWs were analyzed in the study. Age, work and sex did not demonstrate statistically significant values. Statistically significant distribution was found between DASS-21-stress score and COVID/No-COVID (p=0.043). No difference was found in the remaining DASS-21 and PSS scores, dividing the HCWs according to COVID-19-hospital and DP. Conclusion: Working in a COVID-19-hospital represents a factor that negatively affects psychosocial wellbeing. However, DP seems not to affect the psychosocial well-being of BCC HCWs. During the outbreak, psychological support for low risk HCWs should be provided regardless DP. The first case of atypical pneumonia previously named as Severe Acute Respiratory Syndrome Corona Virus 2 (COVID-19) was recorded in December 2019 in China. Italy has been the first European country to be involved in this outbreak. The national health care system (NHS) is currently reallocating resources from elective and semi-elective patients toward severe COVID-19 patients (1, 2). Italy has exceeded the cases recorded in China and unfortunately, up to now (May, 17th), 225,435 cases and 31908 deaths have been registered with still over 700 admitted to intensive care units (3). The Italian outbreak is mainly located in clusters along the north of Italy (Lombardia, Veneto and Emilia Romagna) and a low incidence in central and southern regions (1, 3, 4). In order to control COVID-19, resource reallocation eventually led to the creation of hospitals partially or totally dedicated to COVID-19 patients (COVID-hospital), therefore 1685 This article is freely accessible online.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey

Vanni

Materazzo

Santori

et al. 2020

In Vivo

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“…Alongside, global emergency implied a total reorganization of the Health System: medical resources and supplies are temporary reallocated toward COVID-19 (19) and non-urgent procedures are suffering a significant slowdown (3). In this regard, Breast Units have been strongly affected by these restrictions as well and BC screening programs have been shut down, with a potential impact on women's health and quality of life (4). Breast cancer (BC) is the most frequently diagnosed cancer (24.2%) and the leading cause of cancer-related death (15.0%) in women worldwide (15).…”

Section: Discussionmentioning

confidence: 99%

“…Currently, only urgent imaging is available, according to Government restrictions (2). Both, organized and self-referral screening are temporarily suspended (4). The Shutdown of screening programs along elective activities and the reduction of services could restrict the evaluation to only clinical observation of lesions detected by self-breast examination.…”

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Lockdown of Breast Cancer Screening for COVID-19: Possible Scenario

Vanni

Pellicciaro

Materazzo

et al. 2020

In Vivo

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Background/Aim: Coronavirus disease is spreading worldwide. Due to fast transmission and high fatality rate drastic emergency restrictions were issued. During the lockdown, only urgent medical services are guaranteed. All non-urgent services, as breast cancer (BC) screening, are temporarily suspended. The potential of breast cancer screening programs in increasing the survival rate and decreasing the mortality rate has been widely confirmed. Suspension could lead to worse outcomes for breast cancer patients. Our study aimed to analyse the data and provide estimates regarding the temporary BC screening suspension. Patients and Methods: Data regarding breast cancer and respective screening programs were achieved through literature research and analysis. Results: Considering three different scenarios with respect to the lockdown's impact on breast cancer screening, we estimate that approximately 10,000 patients could have a missed diagnosis during these 3 months. Considering a 6-month period, as suggested by the Imperial college model, the number of patients who will not receive a diagnosis will rise to 16,000. Conclusion: Breast cancer screening should be resumed as soon as possible in order to avoid further breast cancer missed diagnosis and reduce the impact of delayed diagnosis. The Coronavirus disease 2019 (Covid-19) pandemic is becoming incessant, having infected almost four million people worldwide (1). Based on the latest data, in Italy, more than 200,000 people are positive for SARS-COV-2 with a case fatality rate of up to 14% (2). Due to the fast human-to-human transmission and the high fatality rate, on 10 March 2020, the Italian Government, as did other countries, introduced drastic emergency restrictions. These extraordinary measures to limit viral transmission, include: cessation of most activities, quarantine and strict self-isolation (2). Accordingly, this emergency implies a total reorganization of the Health System, including temporary resource reallocation toward COVID-19 (3). Many hospitals are turning into COVID-19 specialized medical centers. During this transition phase, only urgent medical services are guaranteed while oncological procedures are suffering a significant slowdown (3). In this regard, the Breast Unit has been strongly affected by these restrictions as well, with a potential impact on women's health and quality of life (4). Every year, 3 million patients receive a cancer diagnosis worldwide. Breast cancer (BC) corresponds to 14% of cancer diagnoses and to 30% of cancers in women. In Italy, approximately 53,500 women receive a BC diagnosis every year (5). During the last years, there has been an improvement 3047 This article is freely accessible online.

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Delay in breast cancer diagnosis and its clinical consequences during the coronavirus disease pandemic

Koca

Yıldırım

2021

Journal of Surgical Oncology

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Objective: At the end of 1 year of the coronavirus disease (COVID-19) pandemic, we aimed to reveal the changes in breast cancer cases in the context of cause and effect based on the data of surgically treated patients in our institution.Patients and Methods: Patients with breast cancer were divided into two groups.Group 1 consisted of patients who were operated in the year before the COVID-19 pandemic, and Group 2 consisted of patients who were operated within the first year of the pandemic. Tumor size, axillary lymph node positivity, distant organ metastasis status, neoadjuvant chemotherapy, and type of surgery performed were compared between the two groups.Results: The tumor size, axillary lymph node positivity, and neoadjuvant chemotherapy were higher in Group 2 than in Group 1 (p = .005, p = .012, p = .042, respectively). In addition, the number of breast-conserving surgery + sentinel lymph node biopsy were lower, while the number of mastectomy and modified radical mastectomy were higher in Group 2 than in Group 1 (p = .034). Conclusion:Patients presented with larger breast tumors and increased axillary involvement during the pandemic. Moreover, distant organ metastases may increase in the future.

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Breast Cancer Diagnosis in Coronavirus-Era: Alert From Italy

Cited by 39 publications

References 4 publications

The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey

The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey

Lockdown of Breast Cancer Screening for COVID-19: Possible Scenario

Delay in breast cancer diagnosis and its clinical consequences during the coronavirus disease pandemic

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