Breast cancer: correlation of receptor status with clinical presentation, stage of disease, histopathological grade and short term outcome

Abstract

Background: Breast cancer is the commonest female cancer representing a quarter of all cancers worldwide. An important development in breast cancer management was the realization of role of hormone receptors in disease. Thus, the present study was carried out to evaluate the receptor status and its correlation with clinical presentation, stage, grade and short term outcome.Methods: All female patients with lump in breast confirmed as breast cancer were included and their receptor status was evaluated using immunohistochemistry.Results: A total of 147 patients with a mean age of 50.16±12.08 years were enrolled. Almost half of the patients (48.3%) of the patients were found to have locally advanced breast cancer. Of the 147 patients, 91.49% tumours were either Nottingham grade 2 or 3. Triple negative breast cancer (TNBC) was the commonest subtype seen in 43.54% patients. On correlating the results with receptor status, it was found that TNBC patients were younger than HER2neu positive and ER PR positive patients. Also, TNBC patients had a longer duration of lump and the lump was of larger size at presentation. On correlating receptor status with tumour biology it was seen that more than half (54.69%) of the patients who were triple negative had a grade 3 tumour and poorer disease free survival and overall survival.Conclusions: In conclusion it is seen that TNBC forms a majority of the cases in the central Indian population with more aggressive presentations and outcomes. Absence of any targeted therapies against them leads to a worse DFS and overall survival.

Estrogen and Progesterone Receptor Expression in Breast Carcinoma and Its Association With Clinicopathological Variables Among the Pakistani Population

“…Invasive ductal carcinoma, not otherwise specified (IDC-NOS), constituted the most predominant histological type, accounting for 124 (95.4%) cases (Figure 1 ). Similar results were documented in earlier reports, with IDC-NOS being the most common histologic type of breast cancer [ 2 , 7 , 10 - 11 ].…”

“…In our study, Grade III predominated with 66 (50.77%) cases while previous studies in neighboring regions showed Grade II as the most predominant grade [1,6,7,[10][11]. High-grade tumors were mostly negative for hormonal receptors, a finding consistent with that reported by Hashmi et al [6].…”

“…This is comparable to the study performed in Pakistan and India, where 56.8%, 47.6%, and 58.5%cases were ≤50 years of age, respectively (Table 2 ). Zeeshan et al found that 27.4% of breast cancer patients were even younger than 40years [ 7 , 11 - 13 ].…”

Analysis of Carcinoma Breast Patients Presenting to Surgical Unit of a Tertiary Care Centre in Peshawar

“…Similar data is reported by various local and international studies done so far where invasive ductal carcinoma was the most common type of breast cancer. 5,18,[24][25][26] TNM staging of the patients in the current study showed that 14.8% of cases were in stage IV of the disease. A study from Faisalabad showed that 21.7% of cases were in stage IV of the disease which is quite high compared to the figures in the current study.…”