2006
DOI: 10.1002/mc.20248
| View full text |Cite
|
Sign up to set email alerts
|

Abstract: Motility of vascular smooth muscle cells (SMCs) is an essential step for both normal and pathologic angiogenesis. We report here that breast tumor cells, such as MCF-7 and MDA-MB-231, can modulate this SMC migration. We present evidence that the tumor cell-derived platelet-derived growth factor (PDGF) is the key regulator of vascular SMCs motility induced by breast cancer cells. PDGF significantly upregulates neuropilin-1 (NRP-1) mRNA expression and protein production in aortic smooth muscle cells (AOSMCs) and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

3
88
1

Year Published

2008
2008
2023
2023

Publication Types

Select...
5
4
1

Relationship

2
8

Authors

Journals

citations
Cited by 83 publications
(92 citation statements)
references
References 58 publications
(73 reference statements)
3
88
1
Order By: Relevance
“…The phenotype was ascribed largely to EC-specific perturbation of VEGF signaling, since NRP-1 promotes VEGF signal transduction (16,29,41). However, recent studies suggesting that NRP-1 Ab could attenuate pericyte recruitment to tumors provided preliminary evidence that vascular wall cells other than ECs may also be a target for the actions of NRP-1 (18,42). Thus, the present work is timely, since it highlights the sinusoidal HSC as an important target of NRP-1 in liver fibrosis.…”
Section: Discussionmentioning
confidence: 99%
“…The phenotype was ascribed largely to EC-specific perturbation of VEGF signaling, since NRP-1 promotes VEGF signal transduction (16,29,41). However, recent studies suggesting that NRP-1 Ab could attenuate pericyte recruitment to tumors provided preliminary evidence that vascular wall cells other than ECs may also be a target for the actions of NRP-1 (18,42). Thus, the present work is timely, since it highlights the sinusoidal HSC as an important target of NRP-1 in liver fibrosis.…”
Section: Discussionmentioning
confidence: 99%
“…The Western blot analysis was performed according to the previous method (23). Signals were detected with SuperSignal Chemiluminescent Substrate (Pierce) by using ID Image Analysis Software version 3.6 (Eastman Kodak Co.).…”
Section: Methodsmentioning
confidence: 99%
“…Transwell migration assays were performed as described earlier (31). Briefly, MCF-7 cells (20,000 per well) were seeded on 8-Am pore transwell filter insert (Becton Dickinson) coated with fibronectin (10 Ag/mL).…”
Section: Methodsmentioning
confidence: 99%